New Strategies for Microbiological Control in Reproduction

Topic Information

Dear Colleagues，

The use of different strategies to avoid microbial contamination is essential in the different reproductive techniques. In artificial insemination of domestic animals, antibiotics are added to semen extenders, and prophylaxis is a common strategy in hormonally synchronized females to prevent infections that would compromise the success of the whole procedure.

Regarding human reproduction, antibiotic prophylaxis is also used to prevent potential infections derived from different assisted reproductive technologies, including hysteroscopy, laparoscopy, oocyte retrieval and embryo transfer. However, the use of antibiotic prophylaxis is not recommended as a general procedure, both because of secondary effects and as a strategy to slow down the appearance of antibiotic resistance. In fact, different infections of the reproductive tract that have been traditionally treated with antibiotics are becoming resistant to these agents and the need for new candidate strategies to treat them has become an urgent task.

Different organizations worldwide have recommended the limitation of the use of antibiotics to avoid the appearance of new antibiotic-resistance organisms, which is a priority issue to be addressed from all areas of health, including human and animal health to support One Health approach. Considering that, the limitation and promotion of alternatives to antibiotic use in reproduction is one of the main objectives that must be achieved in the short time.

This Topic is focused into finding new strategies for microbial control in reproduction, including animal and human species.

Dr. Ariadna Delgado
Dr. Jordi Ribas-Maynou
Dr. Carolina Maside
Dr. Lorena Padilla
Topic Editors

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Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Antibiotics antibiotics	5.222	3.9	2012	12.6 Days	2200 CHF	Submit
Biomedicines biomedicines	4.757	3.0	2013	17.4 Days	2200 CHF	Submit
Clinics and Practice clinpract	-	-	2011	21.5 Days	1600 CHF	Submit
Journal of Clinical Medicine jcm	4.964	4.4	2012	18 Days	2600 CHF	Submit
Reproductive Medicine reprodmed	-	-	2020	19 Days	1000 CHF	Submit

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All Antibiotics Biomedicines Clinics and Practice JCM Reprod. Med.

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Open AccessArticle

Synergistic Antibiotic Activity of Ricini Semen Extract with Oxacillin against Methicillin-Resistant Staphylococcus aureus

by

Minjun Kim

,

Yena Seo

,

Seon-Gyeong Kim

,

Yedam Choi

,

Hyun Jung Kim

and

Tae-Jong Kim

Antibiotics 2023, 12(2), 340; https://doi.org/10.3390/antibiotics12020340 - 06 Feb 2023

Viewed by 860

Abstract

Resistant bacteria are emerging as a critical problem in the treatment of bacterial infections by neutralizing antibiotic activity. The development of new traditional mechanisms of antibiotics is not the optimal solution. A more reasonable approach may be to use relatively safe, plant-based compounds [...] Read more.

Resistant bacteria are emerging as a critical problem in the treatment of bacterial infections by neutralizing antibiotic activity. The development of new traditional mechanisms of antibiotics is not the optimal solution. A more reasonable approach may be to use relatively safe, plant-based compounds in combination with conventional antibiotics in an effort to increase their efficacy or restore their activity against resistant bacteria. We present our study of mixing Ricini Semen extract, or its constituent fatty acids, with oxacillin and testing the effects of each on the growth of methicillin-resistant Staphylococcus aureus. Changes in the cell membrane fluidity of methicillin-resistant S. aureus were found to be a major component of the mechanism of synergistic antibiotic activity of Ricini Semen extract and its constituent fatty acids. In our model, changes in cellular membrane fluidity disrupted the normal function of bacterial signaling membrane proteins BlaR1 and MecR1, which are known to detect oxacillin, and resulted in the incomplete expression of penicillin-binding proteins 2a and β-lactamase. Utilizing the mechanism presented in this study presents the possibility of developing a method for treating antibiotic-resistant bacteria using traditional antibiotics with plant-based compounds. Full article

(This article belongs to the Topic New Strategies for Microbiological Control in Reproduction)

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