Topic Editors

Dr. Ariadna Delgado
1. Unit of Cell Biology, Department of Biology, Faculty of Sciences, University of Girona, Girona, Spain
2. Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of Girona, Girona, Spain
1. Unit of Cell Biology, Department of Biology, Faculty of Sciences, University of Girona, Girona, Spain
2. Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of Girona, Girona, Spain
Postdoctoral Fellow, Department of Biology, TechnoSperm, University of Girona, Girona, Spain
Dr. Lorena Padilla
1. Unit of Cell Biology, Department of Biology, Faculty of Sciences, University of Girona, Girona, Spain
2. Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of Girona, Girona, Spain

New Strategies for Microbiological Control in Reproduction

Abstract submission deadline
closed (31 August 2023)
Manuscript submission deadline
closed (31 October 2023)
Viewed by
2995

Topic Information

Dear Colleagues,

The use of different strategies to avoid microbial contamination is essential in the different reproductive techniques. In artificial insemination of domestic animals, antibiotics are added to semen extenders, and prophylaxis is a common strategy in hormonally synchronized females to prevent infections that would compromise the success of the whole procedure.

Regarding human reproduction, antibiotic prophylaxis is also used to prevent potential infections derived from different assisted reproductive technologies, including hysteroscopy, laparoscopy, oocyte retrieval and embryo transfer. However, the use of antibiotic prophylaxis is not recommended as a general procedure, both because of secondary effects and as a strategy to slow down the appearance of antibiotic resistance. In fact, different infections of the reproductive tract that have been traditionally treated with antibiotics are becoming resistant to these agents and the need for new candidate strategies to treat them has become an urgent task.

Different organizations worldwide have recommended the limitation of the use of antibiotics to avoid the appearance of new antibiotic-resistance organisms, which is a priority issue to be addressed from all areas of health, including human and animal health to support One Health approach. Considering that, the limitation and promotion of alternatives to antibiotic use in reproduction is one of the main objectives that must be achieved in the short time.

This Topic is focused into finding new strategies for microbial control in reproduction, including animal and human species.

Dr. Ariadna Delgado
Dr. Jordi Ribas-Maynou
Dr. Carolina Maside
Dr. Lorena Padilla
Topic Editors

Keywords

  • reproduction
  • antibiotic
  • antibiotic resistance
  • assisted reproductive techniques
  • microbial contamination

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Antibiotics
antibiotics
4.8 5.5 2012 13.7 Days CHF 2900
Biomedicines
biomedicines
4.7 3.7 2013 15.4 Days CHF 2600
Clinics and Practice
clinpract
2.3 2.0 2011 26.4 Days CHF 1600
Journal of Clinical Medicine
jcm
3.9 5.4 2012 17.9 Days CHF 2600
Reproductive Medicine
reprodmed
- - 2020 29.2 Days CHF 1000

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Published Papers (1 paper)

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16 pages, 2407 KiB  
Article
Synergistic Antibiotic Activity of Ricini Semen Extract with Oxacillin against Methicillin-Resistant Staphylococcus aureus
by Minjun Kim, Yena Seo, Seon-Gyeong Kim, Yedam Choi, Hyun Jung Kim and Tae-Jong Kim
Antibiotics 2023, 12(2), 340; https://doi.org/10.3390/antibiotics12020340 - 6 Feb 2023
Cited by 1 | Viewed by 2017
Abstract
Resistant bacteria are emerging as a critical problem in the treatment of bacterial infections by neutralizing antibiotic activity. The development of new traditional mechanisms of antibiotics is not the optimal solution. A more reasonable approach may be to use relatively safe, plant-based compounds [...] Read more.
Resistant bacteria are emerging as a critical problem in the treatment of bacterial infections by neutralizing antibiotic activity. The development of new traditional mechanisms of antibiotics is not the optimal solution. A more reasonable approach may be to use relatively safe, plant-based compounds in combination with conventional antibiotics in an effort to increase their efficacy or restore their activity against resistant bacteria. We present our study of mixing Ricini Semen extract, or its constituent fatty acids, with oxacillin and testing the effects of each on the growth of methicillin-resistant Staphylococcus aureus. Changes in the cell membrane fluidity of methicillin-resistant S. aureus were found to be a major component of the mechanism of synergistic antibiotic activity of Ricini Semen extract and its constituent fatty acids. In our model, changes in cellular membrane fluidity disrupted the normal function of bacterial signaling membrane proteins BlaR1 and MecR1, which are known to detect oxacillin, and resulted in the incomplete expression of penicillin-binding proteins 2a and β-lactamase. Utilizing the mechanism presented in this study presents the possibility of developing a method for treating antibiotic-resistant bacteria using traditional antibiotics with plant-based compounds. Full article
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