Applications of Polymers and Polymer Nanomaterials in Drug Delivery and Nanomedicine

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closed (31 March 2024)

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31 May 2024

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Topic Information

Dear Colleagues,

The focus of modern pharmaceutical science is aimed at the possibility for control, extension, sustaining, and targeting of the bioactive compounds. Moreover, the efforts are intended to overcome the limitations of the drugs itself, such as decreasing its toxicity and side effects, its instabilities, and unwanted changes. In the field of drug delivery science, polymers have seen significant progress. They provide the possibility for development of delivery systems of higher hierarchical order owing to their unique properties on a molecular and supramolecular level. Their possibility for improvement of the pharmacokinetic properties of drugs is practically unrestricted. This topics is an attempt to summarize recent progress in the knowledge of drug delivery systems based on hydrogels, micro- and nanosized gels, biodegradable polymers, stimuli-responsive systems, polymer and polymer-hybrd nanoparticles, etc., in the development of alternative formulations and administration routes. The evolution of polymer based delivery systems of large molecules as well as biomolecules also will be addressed.

Prof. Dr. Stanislav Rangelov
Dr. Emi Haladjova
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Biomedicines biomedicines	4.7	3.7	2013	15.4 Days	CHF 2600	Submit
Journal of Nanotheranostics jnt	-	-	2020	26.8 Days	CHF 1000	Submit
Pharmaceutics pharmaceutics	5.4	6.9	2009	14.2 Days	CHF 2900	Submit
Macromol macromol	-	-	2021	34.7 Days	CHF 1000	Submit

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Published Papers (3 papers)

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All Biomedicines JNT Pharmaceutics Macromol

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22 pages, 5470 KiB  

Open AccessArticle

Dually Modified Cellulose as a Non-Viral Vector for the Delivery and Uptake of HDAC3 siRNA

by Juliana Hülsmann, Henry Lindemann, Jamila Wegener, Marie Kühne, Maren Godmann, Andreas Koschella, Sina M. Coldewey, Thomas Heinze and Thorsten Heinzel

Pharmaceutics 2023, 15(12), 2659; https://doi.org/10.3390/pharmaceutics15122659 - 23 Nov 2023

Viewed by 910

Abstract

RNA interference can be applied to different target genes for treating a variety of diseases, but an appropriate delivery system is necessary to ensure the transport of intact siRNAs to the site of action. In this study, cellulose was dually modified to create [...] Read more.

RNA interference can be applied to different target genes for treating a variety of diseases, but an appropriate delivery system is necessary to ensure the transport of intact siRNAs to the site of action. In this study, cellulose was dually modified to create a non-viral vector for HDAC3 short interfering RNA (siRNA) transfer into cells. A guanidinium group introduced positive charges into the cellulose to allow complexation of negatively charged genetic material. Furthermore, a biotin group fixed by a polyethylene glycol (PEG) spacer was attached to the polymer to allow, if required, the binding of targeting ligands. The resulting polyplexes with HDAC3 siRNA had a size below 200 nm and a positive zeta potential of up to 15 mV. For N/P ratio 2 and higher, the polymer could efficiently complex siRNA. Nanoparticles, based on this dually modified derivative, revealed a low cytotoxicity. Only minor effects on the endothelial barrier integrity and a transfection efficiency in HEK293 cells higher than Lipofectamine 2000^TM were found. The uptake and release of the polyplexes were confirmed by immunofluorescence imaging. This study indicates that the modified biopolymer is an auspicious biocompatible non-viral vector with biotin as a promising moiety. Full article

(This article belongs to the Topic Applications of Polymers and Polymer Nanomaterials in Drug Delivery and Nanomedicine)

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38 pages, 2567 KiB  

Open AccessEditor’s ChoiceReview

Advances in Pancreatic Cancer Treatment by Nano-Based Drug Delivery Systems

by Cláudia Viegas, Ana B. Patrício, João Prata, Leonor Fonseca, Ana S. Macedo, Sofia O. D. Duarte and Pedro Fonte

Pharmaceutics 2023, 15(9), 2363; https://doi.org/10.3390/pharmaceutics15092363 - 21 Sep 2023

Viewed by 1915

Abstract

Pancreatic cancer represents one of the most lethal cancer types worldwide, with a 5-year survival rate of less than 5%. Due to the inability to diagnose it promptly and the lack of efficacy of existing treatments, research and development of innovative therapies and [...] Read more.

Pancreatic cancer represents one of the most lethal cancer types worldwide, with a 5-year survival rate of less than 5%. Due to the inability to diagnose it promptly and the lack of efficacy of existing treatments, research and development of innovative therapies and new diagnostics are crucial to increase the survival rate and decrease mortality. Nanomedicine has been gaining importance as an innovative approach for drug delivery and diagnosis, opening new horizons through the implementation of smart nanocarrier systems, which can deliver drugs to the specific tissue or organ at an optimal concentration, enhancing treatment efficacy and reducing systemic toxicity. Varied materials such as lipids, polymers, and inorganic materials have been used to obtain nanoparticles and develop innovative drug delivery systems for pancreatic cancer treatment. In this review, it is discussed the main scientific advances in pancreatic cancer treatment by nano-based drug delivery systems. The advantages and disadvantages of such delivery systems in pancreatic cancer treatment are also addressed. More importantly, the different types of nanocarriers and therapeutic strategies developed so far are scrutinized. Full article

(This article belongs to the Topic Applications of Polymers and Polymer Nanomaterials in Drug Delivery and Nanomedicine)

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19 pages, 3600 KiB  

Open AccessReview

Polymeric Theragnostic Nanoplatforms for Bone Tissue Engineering

by Kaushita Banerjee and Harishkumar Madhyastha

J. Nanotheranostics 2023, 4(3), 280-298; https://doi.org/10.3390/jnt4030013 - 20 Jul 2023

Viewed by 1471

Abstract

Nanomaterial-based tissue engineering strategies are precisely designed and tweaked to contest specific patient needs and their end applications. Though theragnostic is a radical term very eminent in cancer prognosis, of late, theragnostic approaches have been explored in the fields of tissue remodulation and [...] Read more.

Nanomaterial-based tissue engineering strategies are precisely designed and tweaked to contest specific patient needs and their end applications. Though theragnostic is a radical term very eminent in cancer prognosis, of late, theragnostic approaches have been explored in the fields of tissue remodulation and reparation. The engineering of theragnostic nanomaterials has opened up avenues for disease diagnosis, imaging, and therapeutic treatments. The instantaneous monitoring of therapeutic strategy is expected to co-deliver imaging and pharmaceutical agents at the same time, and nanoscale carrier moieties are convenient and efficient platforms in theragnostic applications, especially in soft and hard tissue regeneration. Furthermore, imaging modalities have extensively contributed to the signal-to-noise ratio. Simultaneously, there is an accumulation of high concentrations of therapeutic mediators at the defect site. Given the confines of contemporary bone diagnostic systems, the clinical rationale demands nano/biomaterials that can localize to bone-diseased sites to enhance the precision and prognostic value for osteoporosis, non-healing fractures, and/or infections, etc. Furthermore, bone theragnostics may have an even greater clinical impact and multimodal imaging procedures can overcome the restrictions of individual modalities. The present review introduces representative theragnostic polymeric nanomaterials and their advantages and disadvantages in practical use as well as their unique properties. Full article

(This article belongs to the Topic Applications of Polymers and Polymer Nanomaterials in Drug Delivery and Nanomedicine)

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