Bioreactors: Control, Optimization and Applications - 2nd Volume

Topic Information

Dear Colleagues,

Bioreactor are the core of biological processes. The variety of bioprocesses is tremendous, and many different designs of bioreactors have been developed to meet different needs. The success of a bioprocess depends critically on the good design and operation of the bioreactor. The biological systems involved include enzymes, microorganisms, animal cells, plant cells, and tissues. To design an appropriate bioreactor for a particular bioprocess, intensive studies on the biological system, such as cell growth, metabolism, genetic manipulation, and protein or other product expression, are needed to understand the cells’ requirement on their physical and chemical environment. It is also necessary to control and optimize the bioreactor environment via operating variables in order to favor the desired functions of the cells and achieve cost-effective large-scale manufacture. Bioreactor operation strategies include fed-batch, continuous, semicontinuous, and perfusion cultures. For the industrial application of bioreactors, bioreactor scale-up, multiscale study, and bioprocess monitoring, modeling, and simulation are also very important. Moreover, qualitative and quantitative descriptions of a production process through the analysis of various parameters via automatic or manual methods are necessary for process control and optimization. The objects of process monitoring can be the environmental status or the varied values of operational variables. Through analysis, the cellular or engineering problems of a bioreactor on different scales can be identified. Interscale observation and operation are crucial in bioprocess optimization. In this context, there is the necessity for research on “Bioreactors: Control, Optimization and Applications”. The objective of this Topic is to showcase the diversity and advances in research that contribute to developing effective systems for microorganism culture and biochemical production. Original papers are solicited on experimental/theoretical studies on bioreactor systems. We are particularly interested in manuscripts that integrate biology and engineering research and/or experimental and theoretical studies. We invite researchers from all areas of bioengineering to submit manuscripts for this important Topic.

Dr. Francesca Raganati
Dr. Alessandra Procentese
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Applied Sciences applsci	2.7	4.5	2011	15.8 Days	CHF 2300	Submit
Bioengineering bioengineering	4.6	4.2	2014	15.6 Days	CHF 2700	Submit
Fermentation fermentation	3.7	3.7	2015	12.9 Days	CHF 2600	Submit
Processes processes	3.5	4.7	2013	13.9 Days	CHF 2400	Submit
Water water	3.4	5.5	2009	16.6 Days	CHF 2600	Submit

Published Papers (2 papers)

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All Applied Sciences Bioengineering Fermentation Processes Water

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Open AccessArticle

Scalable and High-Throughput In Vitro Vibratory Platform for Vocal Fold Tissue Engineering Applications

by

Andreea Biehl

,

Ramair Colmon

,

Anastasia Timofeeva

,

Ana Maria Gracioso Martins

,

Gregory R. Dion

,

Kara Peters

and

Donald O. Freytes

Bioengineering 2023, 10(5), 602; https://doi.org/10.3390/bioengineering10050602 - 17 May 2023

Viewed by 759

Abstract

The vocal folds (VFs) are constantly exposed to mechanical stimulation leading to changes in biomechanical properties, structure, and composition. The development of long-term strategies for VF treatment depends on the characterization of related cells, biomaterials, or engineered tissues in a controlled mechanical environment. [...] Read more.

The vocal folds (VFs) are constantly exposed to mechanical stimulation leading to changes in biomechanical properties, structure, and composition. The development of long-term strategies for VF treatment depends on the characterization of related cells, biomaterials, or engineered tissues in a controlled mechanical environment. Our aim was to design, develop, and characterize a scalable and high-throughput platform that mimics the mechanical microenvironment of the VFs in vitro. The platform consists of a 24-well plate fitted with a flexible membrane atop a waveguide equipped with piezoelectric speakers which allows for cells to be exposed to various phonatory stimuli. The displacements of the flexible membrane were characterized via Laser Doppler Vibrometry (LDV). Human VF fibroblasts and mesenchymal stem cells were seeded, exposed to various vibratory regimes, and the expression of pro-fibrotic and pro-inflammatory genes was analyzed. Compared to current bioreactor designs, the platform developed in this study can incorporate commercial assay formats ranging from 6- to 96-well plates which represents a significant improvement in scalability. This platform is modular and allows for tunable frequency regimes. Full article

(This article belongs to the Topic Bioreactors: Control, Optimization and Applications - 2nd Volume)

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Open AccessArticle

Study on Scale-Up of Anaerobic Fermentation Mixing with Different Solid Content

by

Zhe Li

,

Hancheng Lu

,

Zixuan Zhang

and

Baoqing Liu

Fermentation 2023, 9(4), 375; https://doi.org/10.3390/fermentation9040375 - 14 Apr 2023

Viewed by 1451

Abstract

The scale-up technology of anaerobic fermentation stirring equipment is worthy of attention. Computational fluid dynamics (CFD) simulations were used to study the scale-up of anaerobic fermentation mixing under different solid content conditions. The applicability of different scale-up criteria was analyzed by investigating the [...] Read more.

The scale-up technology of anaerobic fermentation stirring equipment is worthy of attention. Computational fluid dynamics (CFD) simulations were used to study the scale-up of anaerobic fermentation mixing under different solid content conditions. The applicability of different scale-up criteria was analyzed by investigating the relative parameters, such as the blade tip speed and the Reynolds number. On this basis, the scale-up index was optimized and verified. The results revealed the applicability of five common scale-up criteria under different solid content conditions. When the solid content is less than 5%, the anaerobic fermentation tank should be scaled up according to the same Weber number. When the solid content is between 5% and 10%, the anaerobic fermentation tank should be scaled up according to the same blade tip speed; it was especially suitable for anaerobic fermentation and other conditions that limit the shear rate. Scaling up according to the Reynolds number was not recommended due to the poor mixing effect. When the scale-up index x reached 0.75, there was no need to further reduce it. For anaerobic fermentation systems, the suitable scale-up indices selected for 5%, 10%, and 15% solid content were 1.1, 1, and 0.75, respectively. Full article

(This article belongs to the Topic Bioreactors: Control, Optimization and Applications - 2nd Volume)

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