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Pathogenesis of Pregnancy-Related Complications 2.0
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Head, Dpt. Molecular Biology and Cell Pathology, Third Faculty of Medicine, Charles University, Prague, Czech Republic
Dr. Katerina Kotlabova
Department Molecular Biology and Cell Pathology, Third Faculty of Medicine, Charles University, Prague, Czech Republic
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Pathogenesis of Pregnancy-Related Complications 2.0

Abstract submission deadline
closed (30 April 2023)
Manuscript submission deadline
30 June 2023
Viewed by
2570

Topic Information

Dear Colleagues,

Preeclampsia, HELLP syndrome, fetal growth restriction, gestational diabetes mellitus, preterm birth (preterm prelabor rupture of membranes and spontaneous preterm labor), and an invasive placenta are major complications responsible for maternal and perinatal morbidity and mortality. The elucidation of the pathogenetic mechanisms related to the initiation and onset of severe pregnancy-related complications enables the identification of potential biomarkers for the early stratification of at-risk patients. Additionally, pregnancy-related complications induce long-term metabolic and vascular abnormalities that might increase the overall risk of metabolic, cardiovascular, cerebrovascular, kidney, and other diseases later in life in mothers and their offspring. This Topic aims to provide an overview of the latest research on the mechanisms associated with pregnancy-related complications as well as on the contributions of pregnancy-related complications to the later development of various diseases. This will include the underlying mechanisms, diagnostics/prognostics, and treatment strategies associated with pregnancy-related complications, and will be of interest to scientists and clinicians working in this quickly expanding area.

Topics will include (but are not limited to) the following:

  • Pathogenesis of pregnancy-related complications;
  • Diagnosis and prognosis of pregnancy-related complications;
  • Short-term and long-term follow-up after pregnancy-related complications (mothers and offspring);
  • Novel treatment modalities of pregnancy-related complications and their short-term as well as long-term consequences.

Prof. Dr. Ilona Hromadnikova
Dr. Katerina Kotlabova
Topic Editors

Keywords

  • gestational hypertension
  • preeclampsia
  • HELLP syndrome
  • fetal growth restriction
  • gestational diabetes mellitus
  • preterm birth
  • invasive placenta

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Biomedicines
biomedicines 		4.757 3.7 2013 17.4 Days 2200 CHF Submit
Current Issues in Molecular Biology
cimb 		2.976 2.4 1999 17.2 Days 2000 CHF Submit
Endocrines
endocrines 		- - 2020 27.5 Days 1000 CHF Submit
International Journal of Molecular Sciences
ijms 		6.208 7.8 2000 15.9 Days 2500 CHF Submit
Journal of Molecular Pathology
jmp 		- - 2020 13.5 Days 1000 CHF Submit
Life
life 		3.253 2.7 2011 13.4 Days 1800 CHF Submit
Reproductive Medicine
reprodmed 		- - 2020 19 Days 1000 CHF Submit

Preprints is a platform dedicated to making early versions of research outputs permanently available and citable. MDPI journals allow posting on preprint servers such as Preprints.org prior to publication. For more details about reprints, please visit https://www.preprints.org.

Published Papers (2 papers)

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Review
Regulation of SIRT1 in Ovarian Function: PCOS Treatment
by
Xinrong Li
,
Yuxu He
,
Shuang Wu
,
Peiwen Zhang
,
Mailin Gan
,
Lei Chen
,
Ye Zhao
,
Lili Niu
,
Shunhua Zhang
,
Yanzhi Jiang
,
Zongyi Guo
,
Jinyong Wang
,
Linyuan Shen
and
Li Zhu
Curr. Issues Mol. Biol. 2023, 45(3), 2073-2089; https://doi.org/10.3390/cimb45030133 - 02 Mar 2023
Viewed by 882
Abstract
The sirtuin family, a group of NAD+-dependent class 3 histone deacetylases (HDACs), was extensively studied initially as a group of longevity genes that are activated in caloric restriction and act in concert with nicotinamide adenine dinucleotides to extend the lifespan. Subsequent studies have [...] Read more.
The sirtuin family, a group of NAD+-dependent class 3 histone deacetylases (HDACs), was extensively studied initially as a group of longevity genes that are activated in caloric restriction and act in concert with nicotinamide adenine dinucleotides to extend the lifespan. Subsequent studies have found that sirtuins are involved in various physiological processes, including cell proliferation, apoptosis, cell cycle progression, and insulin signaling, and they have been extensively studied as cancer genes. In recent years, it has been found that caloric restriction increases ovarian reserves, suggesting that sirtuins may play a regulatory role in reproductive capacity, and interest in the sirtuin family has continued to increase. The purpose of this paper is to summarize the existing studies and analyze the role and mechanism of SIRT1, a member of the sirtuin family, in regulating ovarian function. Research and review on the positive regulation of SIRT1 in ovarian function and its therapeutic effect on PCOS syndrome. Full article
(This article belongs to the Topic Pathogenesis of Pregnancy-Related Complications 2.0)
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Review
Difficulties in Adaptation of the Mother and Newborn via Cesarean Section versus Natural Birth—A Narrative Review
by
Vasile Valeriu Lupu
,
Ingrith Crenguta Miron
,
Anca Adam Raileanu
,
Iuliana Magdalena Starcea
,
Ancuta Lupu
,
Elena Tarca
,
Adriana Mocanu
,
Ana Maria Laura Buga
,
Valeriu Lupu
and
Silvia Fotea
Life 2023, 13(2), 300; https://doi.org/10.3390/life13020300 - 21 Jan 2023
Cited by 5 | Viewed by 925
Abstract
Birth is a physiological act that is part of the morpho-functional economy of the maternal body. Each stage in the act of birth has a predetermined pathway that is neurohormonally induced and morpho-functionally established through specific and characteristic adaptations. Like maternity, childbirth also [...] Read more.
Birth is a physiological act that is part of the morpho-functional economy of the maternal body. Each stage in the act of birth has a predetermined pathway that is neurohormonally induced and morpho-functionally established through specific and characteristic adaptations. Like maternity, childbirth also has an important impact on the maternal body as a biological structure and psycho-emotional behavior. Cesarean section performed at the request of the mother with no medical underlying conditions besides the prolonged hospitalization risk can also cause breathing problems in children, delayed breastfeeding, and possible complications in a future pregnancy. Vaginal birth remains the path of choice for a physiological evolution pregnancy. Although erroneously considered safe and easy today, cesarean section delivery must remain an emergency procedure or a procedure recommended for pregnancies where birth is a risk to the mother and to the child, as cesarean section itself is a risk factor for negative outcomes for both mother and baby. This review summarizes the impact that both cesarean section and natural birth have on mother and newborn in their attempt to adapt to postpartum events and extrauterine life. Full article
(This article belongs to the Topic Pathogenesis of Pregnancy-Related Complications 2.0)
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