Usefulness and Clinical Applications of 3D Printing in Cardiovascular Diseases 2.0

Topic Information

Dear Colleagues,

Given the success of the first edition, we believe it is the time to launch the second edition of this Topic. This second edition of the Topic aims to focus on recent advances in 3D printing and its value or applications in cardiovascular diseases. Three-dimensional printing has evolved rapidly over the last decade, showing great potential in many medical domains, in particular, in the field of cardiovascular disease. Patient-specific or personalized 3D-printed models are shown to enhance our understanding of complex cardiac anatomy and pathology; assist presurgical planning and the simulation of complicated procedures for the treatment of cardiovascular diseases; improve the education of medical students or healthcare professionals; and improve communication between physicians and patients. This issue will highlight the current advances in 3D printing, with special emphasis given to patient-specific 3D-printed models in the diagnosis and management of congenital heart disease and other cardiovascular diseases. Technological developments, including 3D printing materials and bioprinting or tissue engineering, 3D printing integrated with virtual reality and augmented reality, as well as artificial intelligence, are also included in the potential topics of this Topic.

Prof. Dr. Zhonghua Sun
Prof. Dr. Massimo Chessa
Dr. Israel Valverde
Prof. Dr. Alexander Van De Bruaene
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Applied Biosciences applbiosci	-	-	2022	37.7 Days	CHF 1000
Bioengineering bioengineering	4.6	4.2	2014	17.7 Days	CHF 2700
Biomolecules biomolecules	5.5	8.3	2011	16.9 Days	CHF 2700
Journal of Cardiovascular Development and Disease jcdd	2.4	2.4	2014	20.3 Days	CHF 2700
Journal of Clinical Medicine jcm	3.9	5.4	2012	17.9 Days	CHF 2600
Micromachines micromachines	3.4	4.7	2010	16.1 Days	CHF 2600
Reports reports	0.9	-	2018	20.6 Days	CHF 1400

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Published Papers (3 papers)

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Journals

All Applied Biosciences Bioengineering Biomolecules JCDD JCM Micromachines Reports

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Supplementary material:
Supplementary File 1 (ZIP, 3086 KiB)

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Open AccessCase Report

Transapical Mitral Valve-in-Ring Replacement Using the Innovative System under 3-Dimensional Printing Guidance

by Yiwei Wang, Yu Mao, Mengen Zhai, Yanyan Ma, Lanlan Li, Yang Liu and Jian Yang

J. Cardiovasc. Dev. Dis. 2023, 10(8), 339; https://doi.org/10.3390/jcdd10080339 - 07 Aug 2023

Viewed by 1170

Abstract

Background: Transcatheter mitral valve-in-ring replacement (TMViR) is an emerging alternative for patients with recurrent mitral regurgitation (MR) after a prior failed annuloplasty ring. However, intraoperative common issues and complications remain to be addressed. Case summary: We describe the case of a 67-year-old male [...] Read more.

Background: Transcatheter mitral valve-in-ring replacement (TMViR) is an emerging alternative for patients with recurrent mitral regurgitation (MR) after a prior failed annuloplasty ring. However, intraoperative common issues and complications remain to be addressed. Case summary: We describe the case of a 67-year-old male patient who underwent surgical mitral concomitant tricuspid annuloplasty repair 7 years ago who developed recurrent severe MR (New York Heart Association functional class IV). To avoid a high-risk surgical reoperation, we chose to perform a TMViR using an innovative dedicated device—the Mi-thos system—via a transapical approach. A patient-specific, 3-dimensional printed model was used to guide the procedure to avoid potential challenges. The procedure was performed successfully, and the patient exhibited symptomatic improvement. Conclusions: This case report highlights the first use of the innovative Mi-thos system in a TMViR procedure. The findings demonstrate the feasibility and safety of utilizing the Mi-thos system, guided by 3-dimensional printing technology, for patients who have experienced recurrent mitral regurgitation MR following a failed annuloplasty ring. Full article

(This article belongs to the Topic Usefulness and Clinical Applications of 3D Printing in Cardiovascular Diseases 2.0)

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29 pages, 6940 KiB  

Open AccessReview

Three-Dimensional Bioprinting in Cardiovascular Disease: Current Status and Future Directions

by Zhonghua Sun, Jack Zhao, Emily Leung, Maria Flandes-Iparraguirre, Michael Vernon, Jenna Silberstein, Elena M. De-Juan-Pardo and Shirley Jansen

Biomolecules 2023, 13(8), 1180; https://doi.org/10.3390/biom13081180 - 28 Jul 2023

Cited by 5 | Viewed by 2473

Abstract

Three-dimensional (3D) printing plays an important role in cardiovascular disease through the use of personalised models that replicate the normal anatomy and its pathology with high accuracy and reliability. While 3D printed heart and vascular models have been shown to improve medical education, [...] Read more.

Three-dimensional (3D) printing plays an important role in cardiovascular disease through the use of personalised models that replicate the normal anatomy and its pathology with high accuracy and reliability. While 3D printed heart and vascular models have been shown to improve medical education, preoperative planning and simulation of cardiac procedures, as well as to enhance communication with patients, 3D bioprinting represents a potential advancement of 3D printing technology by allowing the printing of cellular or biological components, functional tissues and organs that can be used in a variety of applications in cardiovascular disease. Recent advances in bioprinting technology have shown the ability to support vascularisation of large-scale constructs with enhanced biocompatibility and structural stability, thus creating opportunities to replace damaged tissues or organs. In this review, we provide an overview of the use of 3D bioprinting in cardiovascular disease with a focus on technologies and applications in cardiac tissues, vascular constructs and grafts, heart valves and myocardium. Limitations and future research directions are highlighted. Full article

(This article belongs to the Topic Usefulness and Clinical Applications of 3D Printing in Cardiovascular Diseases 2.0)

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14 pages, 5002 KiB  

Open AccessArticle

Clinical Applications of Mixed Reality and 3D Printing in Congenital Heart Disease

by Ivan Lau, Ashu Gupta, Abdul Ihdayhid and Zhonghua Sun

Biomolecules 2022, 12(11), 1548; https://doi.org/10.3390/biom12111548 - 24 Oct 2022

Cited by 7 | Viewed by 1882

Abstract

Understanding the anatomical features and generation of realistic three-dimensional (3D) visualization of congenital heart disease (CHD) is always challenging due to the complexity and wide spectrum of CHD. Emerging technologies, including 3D printing and mixed reality (MR), have the potential to overcome these [...] Read more.

Understanding the anatomical features and generation of realistic three-dimensional (3D) visualization of congenital heart disease (CHD) is always challenging due to the complexity and wide spectrum of CHD. Emerging technologies, including 3D printing and mixed reality (MR), have the potential to overcome these limitations based on 2D and 3D reconstructions of the standard DICOM (Digital Imaging and Communications in Medicine) images. However, very little research has been conducted with regard to the clinical value of these two novel technologies in CHD. This study aims to investigate the usefulness and clinical value of MR and 3D printing in assisting diagnosis, medical education, pre-operative planning, and intraoperative guidance of CHD surgeries through evaluations from a group of cardiac specialists and physicians. Two cardiac computed tomography angiography scans that demonstrate CHD of different complexities (atrial septal defect and double outlet right ventricle) were selected and converted into 3D-printed heart models (3DPHM) and MR models. Thirty-four cardiac specialists and physicians were recruited. The results showed that the MR models were ranked as the best modality amongst the three, and were significantly better than DICOM images in demonstrating complex CHD lesions (mean difference (MD) = 0.76, p = 0.01), in enhancing depth perception (MD = 1.09, p = 0.00), in portraying spatial relationship between cardiac structures (MD = 1.15, p = 0.00), as a learning tool of the pathology (MD = 0.91, p = 0.00), and in facilitating pre-operative planning (MD = 0.87, p = 0.02). The 3DPHM were ranked as the best modality and significantly better than DICOM images in facilitating communication with patients (MD = 0.99, p = 0.00). In conclusion, both MR models and 3DPHM have their own strengths in different aspects, and they are superior to standard DICOM images in the visualization and management of CHD. Full article

(This article belongs to the Topic Usefulness and Clinical Applications of 3D Printing in Cardiovascular Diseases 2.0)

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