Tissue-Specific, Disease-Signatured Macrophages in Control of Redox and Antioxidation in Metabolic Diseases

Topic Information

Dear Colleagues,

Reactive oxygen species (ROS) compose a complicated network signaling system, known as redox regulation, which is critical for maintenance of the homeostasis and metabolism of the human body. The imbalance of oxidation and anti-oxidation causes metabolic disorders, leading to many prevalent diseases, such as cancer, cardiovascular diseases, neurodegenerative diseases and diabetes. Macrophages play a pivotal role in immunity and nearly all physiological and pathological processes, during which macrophages act not only as one of the major target cells of oxidants, but also as important effector cells of inducible endogenous antioxidants. Accumulating evidence has demonstrated a pattern that macrophages dynamically adjust their activation profile toward a steadily changing microenvironment that requires altering their phenotype, a process known as macrophage polarization. Recent studies have shown that macrophage polarization is far more complicated than the classically catalogized proinflammatory M1 and anti-inflammatory M2, but more likely into a wide spectrum of phenotypes that do not fit rigidly into the definition of M1 or M2. To this end, studies on the tissue-specific, disease-signatured macrophage phenotypes appeared to be important for improving our understanding on the crosstalk between macrophages and microenvironment to regulate redox, metabolism, inflammation and immunity. After the outbreak of COVID-19, a notion arises that macrophages-associated regulation of ROS and immunity is altered by the viral infection and contributes to the disease progression and aggravation. The goal of this research topic aims to provide a scientific forum for the latest and innovative research for better understanding the role of macrophages as well as their specific polarization in the control of microenvironmental oxidative status that governs the initiation and progression of cancer, cardiovascular diseases, neurodegenerative diseases, diabetes and other related metabolic disorders. The scope of this research topic issue preferentially covers the latest and advanced results with innovative findings on the roles of macrophages, especially the specific phenotypic alteration of macrophages, in the control of microenvironmental oxidative status that governs the initiation and progression of cancer, cardiovascular diseases, neurodegenerative diseases, diabetes and other related metabolic disorders. Both research and review articles are welcome except case reports.

Dr. Xiangwei Xiao
Dr. Yingmei Feng
Dr. Zhiyong Lei
Topic Editors

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Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Antioxidants antioxidants	7.0	8.8	2012	13.9 Days	CHF 2900	Submit
Biomolecules biomolecules	5.5	8.3	2011	16.9 Days	CHF 2700	Submit
Journal of Cardiovascular Development and Disease jcdd	2.4	2.4	2014	20.3 Days	CHF 2700	Submit
Metabolites metabolites	4.1	5.3	2011	13.2 Days	CHF 2700	Submit
Neurology International neurolint	3.0	2.2	2009	23.3 Days	CHF 1600	Submit
Pharmaceutics pharmaceutics	5.4	6.9	2009	14.2 Days	CHF 2900	Submit

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All Antioxidants Biomolecules JCDD Metabolites Neurology International Pharmaceutics

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Open AccessArticle

Lactiplantibacillus plantarum and Saussurea costus as Therapeutic Agents against a Diabetic Rat Model—Approaches to Investigate Pharmacophore Modeling of Human IkB Kinase and Molecular Interaction with Dehydrocostus Lactone of Saussurea costus

by Metab A. AlGeffari, Dina Mansour, Omar Ahmed-Farid, Einas Mohamed Yousef, Shereen A. Mohamed, Mahmoud M. A. Moustafa, Hassan Barakat and Khalid Abd El Ghany

Metabolites 2023, 13(6), 764; https://doi.org/10.3390/metabo13060764 - 19 Jun 2023

Viewed by 1388

Abstract

Lactic acid bacteria is well-known as a vital strategy to alleviate or prevent diabetes. Similarly, the plant Saussurea costus (Falc) Lipsch is a preventive power against diabetes. Here, we aimed to determine whether lactic acid bacteria or Saussurea costus is more effective in [...] Read more.

Lactic acid bacteria is well-known as a vital strategy to alleviate or prevent diabetes. Similarly, the plant Saussurea costus (Falc) Lipsch is a preventive power against diabetes. Here, we aimed to determine whether lactic acid bacteria or Saussurea costus is more effective in treating a diabetic rat model in a comparative study manner. An in vivo experiment was conducted to test the therapeutic activity of Lactiplantibacillus plantarum (MW719476.1) and S. costus plants against an alloxan-induced diabetic rat model. Molecular, biochemical, and histological analyses were investigated to evaluate the therapeutic characteristics of different treatments. The high dose of S. costus revealed the best downregulated expression for the IKBKB, IKBKG, NfkB1, IL-17A, IL-6, IL-17F, IL-1β, TNF-α, TRAF6, and MAPK genes compared to Lactiplantibacillus plantarum and the control groups. The downregulation of IKBKB by S. costus could be attributed to dehydrocostus lactone as an active compound with proposed antidiabetic activity. So, we performed another pharmacophore modeling analysis to test the possible interaction between human IkB kinase beta protein and dehydrocostus lactone as an antidiabetic drug. Molecular docking and MD simulation data confirmed the interaction between human IkB kinase beta protein and dehydrocostus lactone as a possible drug. The target genes are important in regulating type 2 diabetes mellitus signaling, lipid and atherosclerosis signaling, NF-κB signaling, and IL-17 signaling pathways. In conclusion, the S. costus plant could be a promising source of novel therapeutic agents for treating diabetes and its complications. Dehydrocostus lactone caused the ameliorative effect of S. costus by its interaction with human IkB kinase beta protein. Further, future studies could be conducted to find the clinical efficacy of dehydrocostus lactone. Full article

(This article belongs to the Topic Tissue-Specific, Disease-Signatured Macrophages in Control of Redox and Antioxidation in Metabolic Diseases)

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