Retroviral Capsid: Assembly, Maturation and Interaction with Host and Antiviral Factors

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 386

Special Issue Editors

Institute for Molecular Virology, Division of Basic Sciences, University of Minnesota, 18-242 Moos Tower, 515 Delaware St. SE, Minneapolis, MN 55455, USA
Interests: structure virology; human retrovirus; alphavirus; cryo-electron microscopy; image processing; 3D reconstruction
Institute for Molecular Virology, Division of Basic Sciences, University of Minnesota, Minneapolis, MN, USA
Interests: human retroviruses; virus assembly; reverse transcription; retroviral diversity and evolution; antiretroviral
Special Issues, Collections and Topics in MDPI journals
Institute for Molecular Virology, Division of Basic Sciences, University of Minnesota, 18-242 Moos Tower, 515 Delaware St. SE, Minneapolis, MN 55455, USA
Interests: structural virology; cryo-electron microscopy; cryo-eletron tomography; retroviral assembly; membrane biology; membrane fission

Special Issue Information

Dear Colleagues,

The retroviral capsid (CA) protein is involved in multiple steps in the virus life cycle. In virus particle assembly, the CA protein is the key driver in forming the hexameric lattice found in immature particles, and following virus maturation forms a CA core in mature virus particles. Following infection, the CA protein is involved in core trafficking, uncoating, reverse transcription, and nuclear entry. CA is recognized by numerous cellular proteins, including those that can either facilitate or restrict CA core stability, trafficking, and/or nuclear entry. Mutation of CA and targeting by novel antiretroviral compounds can perturb core stability and particle infectivity. Structure-function analysis of CA variants and CA bound to small molecules have provided further insights into CA function and the mechanism of small molecule antiviral action.

This special issue aims to highlight the cutting-edge advancements in methods and research on the retroviral CA protein, spanning topics such as CA trafficking and nuclear import, core stability, reverse transcription, virion assembly, maturation, and interactions with the host proteins and antiviral molecules.

Dr. Wei Zhang
Dr. Louis M. Mansky
Dr. Nathaniel Talledge
Guest Editors

Manuscript Submission Information

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Keywords

  • human retrovirus
  • capsid
  • envelope
  • assembly
  • budding
  • maturation
  • structure
  • antiviral
  • host factor

Published Papers

There is no accepted submissions to this special issue at this moment.
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