Editorial

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Open AccessEditorial

Special Issue “Emerging Virus Infections in Adverse Pregnancy Outcomes”

by Léo Pomar and David Baud

Viruses 2022, 14(2), 285; https://doi.org/10.3390/v14020285 - 29 Jan 2022

Cited by 1 | Viewed by 1791

Abstract

Dear contributors and readers, [...] Full article

(This article belongs to the Special Issue Emerging Virus Infections in Adverse Pregnancy Outcomes)

Research

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9 pages, 4746 KiB

Open AccessArticle

Maternal Death by COVID-19 Associated with Elevated Troponin T Levels

by Johnatan Torres-Torres, Raigam Jafet Martinez-Portilla, Salvador Espino y Sosa, Juan Mario Solis-Paredes, Jose Antonio Hernández-Pacheco, Paloma Mateu-Rogell, Anette Cravioto-Sapien, Adolfo Zamora-Madrazo, Guadalupe Estrada-Gutierrez, Miguel Angel Nares-Torices, Norma Patricia Becerra-Navarro, Virginia Medina-Jimenez, Jose Rafael Villafan-Bernal, Lourdes Rojas-Zepeda, Diana Hipolita Loya-Diaz and Manuel Casillas-Barrera

Viruses 2022, 14(2), 271; https://doi.org/10.3390/v14020271 - 28 Jan 2022

Cited by 5 | Viewed by 2719

Abstract

Cardiomyocyte injury and troponin T elevation has been reported within COVID-19 patients and are associated with a worse prognosis. Limited data report this association among COVID-19 pregnant patients. Objective: We aimed to analyze the association between troponin T levels in severe COVID-19 pregnant [...] Read more.

Cardiomyocyte injury and troponin T elevation has been reported within COVID-19 patients and are associated with a worse prognosis. Limited data report this association among COVID-19 pregnant patients. Objective: We aimed to analyze the association between troponin T levels in severe COVID-19 pregnant women and risk of viral sepsis, intensive care unit (ICU) admission, or maternal death. Methods: We performed a prospective cohort of all obstetrics emergency admissions from a Mexican National Institute. All pregnant women diagnosed by reverse transcription-polymerase chain reaction (RT-qPCR) for SARS-CoV-2 infection between October 2020 and May 2021 were included. Clinical data were collected, and routine blood samples were obtained at hospital admission. Seric troponin T was measured at admission. Results: From 87 included patients, 31 (35.63%) had severe COVID-19 pneumonia, and 6 (6.89%) maternal deaths. ROC showed a significant relationship between troponin T and maternal death (AUC 0.979, CI 0.500–1.000). At a cutoff point of 7 ng/mL the detection rate for severe pneumonia was 83.3% (95%CI: 0.500–0.100) at 10% false-positive rate. Conclusion: COVID-19 pregnant women with elevated levels of troponin T present a higher risk of death and severe pneumonia. Full article

(This article belongs to the Special Issue Emerging Virus Infections in Adverse Pregnancy Outcomes)

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5 pages, 216 KiB

Open AccessCommunication

Letter to the Editor: SFlt-1 and PlGF Levels in Pregnancies Complicated by SARS-CoV-2 Infection

by Valentina Giardini, Sara Ornaghi, Eleonora Acampora, Maria Viola Vasarri, Francesca Arienti, Carlo Gambacorti-Passerini, Marco Casati, Andrea Carrer and Patrizia Vergani

Viruses 2021, 13(12), 2377; https://doi.org/10.3390/v13122377 - 27 Nov 2021

Cited by 5 | Viewed by 1950

Abstract

We read with interest the work by Espino-y-Sosa and colleagues [...] Full article

(This article belongs to the Special Issue Emerging Virus Infections in Adverse Pregnancy Outcomes)

18 pages, 4493 KiB

Open AccessArticle

Embryonic Stage of Congenital Zika Virus Infection Determines Fetal and Postnatal Outcomes in Mice

by Eri Nakayama, Yasuhiro Kawai, Satoshi Taniguchi, Jessamine E. Hazlewood, Ken-ichi Shibasaki, Kenta Takahashi, Yuko Sato, Bing Tang, Kexin Yan, Naoko Katsuta, Shigeru Tajima, Chang Kweng Lim, Tadaki Suzuki, Andreas Suhrbier and Masayuki Saijo

Viruses 2021, 13(9), 1807; https://doi.org/10.3390/v13091807 - 11 Sep 2021

Cited by 2 | Viewed by 2097

Abstract

Zika virus (ZIKV) infection during pregnancy causes a wide spectrum of congenital abnormalities and postnatal developmental sequelae such as fetal loss, intrauterine growth restriction (IUGR), microcephaly, or motor and neurodevelopmental disorders. Here, we investigated whether a mouse pregnancy model recapitulated a wide range [...] Read more.

Zika virus (ZIKV) infection during pregnancy causes a wide spectrum of congenital abnormalities and postnatal developmental sequelae such as fetal loss, intrauterine growth restriction (IUGR), microcephaly, or motor and neurodevelopmental disorders. Here, we investigated whether a mouse pregnancy model recapitulated a wide range of symptoms after congenital ZIKV infection, and whether the embryonic age of congenital infection changed the fetal or postnatal outcomes. Infection with ZIKV strain PRVABC59 from embryonic day 6.5 (E6.5) to E8.5, corresponding to the mid-first trimester in humans, caused fetal death, fetal resorption, or severe IUGR, whereas infection from E9.5 to E14.5, corresponding to the late-first to second trimester in humans, caused stillbirth, neonatal death, microcephaly, and postnatal growth deficiency. Furthermore, 4-week-old offspring born to dams infected at E12.5 showed abnormalities in neuropsychiatric state, motor behavior, autonomic function, or reflex and sensory function. Thus, our model recapitulated the multiple symptoms seen in human cases, and the embryonic age of congenital infection was one of the determinant factors of offspring outcomes in mice. Furthermore, maternal neutralizing antibodies protected the offspring from neonatal death after congenital infection at E9.5, suggesting that neonatal death in our model could serve as criteria for screening of vaccine candidates. Full article

(This article belongs to the Special Issue Emerging Virus Infections in Adverse Pregnancy Outcomes)

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10 pages, 428 KiB

Open AccessArticle

Maternal and Neonatal Outcomes of SARS-CoV-2 Infection in a Cohort of Pregnant Women with Comorbid Disorders

by Maria de Lourdes Benamor Teixeira, Orlando da Costa Ferreira Júnior, Esaú João, Trevon Fuller, Juliana Silva Esteves, Wallace Mendes-Silva, Carolina Carvalho Mocarzel, Richard Araújo Maia, Lídia Theodoro Boullosa, Cássia Cristina Alves Gonçalves, Patrícia Pontes Frankel and Maria Isabel Fragoso da Silveira Gouvêa

Viruses 2021, 13(7), 1277; https://doi.org/10.3390/v13071277 - 30 Jun 2021

Cited by 11 | Viewed by 2622

Abstract

There are some reports and case series addressing Coronavirus Disease 2019 (COVID-19) infections during pregnancy in upper income countries, but there are few data on pregnant women with comorbid conditions in low and middle income Countries. This study evaluated the proportion and the [...] Read more.

There are some reports and case series addressing Coronavirus Disease 2019 (COVID-19) infections during pregnancy in upper income countries, but there are few data on pregnant women with comorbid conditions in low and middle income Countries. This study evaluated the proportion and the maternal and neonatal outcomes associated with SARS-CoV-2 infection among pregnant women with comorbidities. Participants were recruited consecutively in order of admission to a maternity for pregnant women with comorbidities. Sociodemographic, clinical, and laboratory data were prospectively collected during hospitalization. Pregnant women were screened at entry: nasopharyngeal swabs were tested by RT-PCR; serum samples were tested for IgG antibodies against spike protein by ELISA. From April to June 2020, 115 eligible women were included in the study. The proportion of SARS-CoV-2 infection was 28.7%. The rate of obesity was 60.9%, vascular hypertension 40.0%, and HIV 21.7%. The most common clinical presentations were ageusia (21.2%), anosmia (18.2%), and fever (18.2%). Prematurity was higher among mothers who had a SARS-CoV-2 infection based on RT-PCR. There were two cases of fetal demise. We found a high proportion of COVID-19 among pregnant women with comorbidities. This underscores the importance of antenatal care during the pandemic to implement universal SARS-CoV-2 screening, precautionary measures, and the rollout of vaccination programs for pregnant women. Full article

(This article belongs to the Special Issue Emerging Virus Infections in Adverse Pregnancy Outcomes)

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13 pages, 856 KiB

Open AccessArticle

SARS-CoV-2 Vaccine Willingness among Pregnant and Breastfeeding Women during the First Pandemic Wave: A Cross-Sectional Study in Switzerland

by Sarah Stuckelberger, Guillaume Favre, Michael Ceulemans, Hedvig Nordeng, Eva Gerbier, Valentine Lambelet, Milos Stojanov, Ursula Winterfeld, David Baud, Alice Panchaud and Léo Pomar

Viruses 2021, 13(7), 1199; https://doi.org/10.3390/v13071199 - 22 Jun 2021

Cited by 55 | Viewed by 5416

Abstract

As pregnant women are at high risk of severe SARS-CoV-2 infection and COVID-19 vaccines are available in Switzerland, this study aimed to assess the willingness of Swiss pregnant and breastfeeding women to become vaccinated. Through a cross-sectional online study conducted after the first [...] Read more.

As pregnant women are at high risk of severe SARS-CoV-2 infection and COVID-19 vaccines are available in Switzerland, this study aimed to assess the willingness of Swiss pregnant and breastfeeding women to become vaccinated. Through a cross-sectional online study conducted after the first pandemic wave, vaccination practices and willingness to become vaccinated against SARS-CoV-2 if a vaccine was available were evaluated through binary, multi-choice, and open-ended questions. Factors associated with vaccine willingness were evaluated through univariable and multivariable analysis. A total of 1551 women responded to questions related to the primary outcome. Only 29.7% (153/515) of pregnant and 38.6% (400/1036) of breastfeeding women were willing to get vaccinated against SARS-CoV-2 if a vaccine had been available during the first wave. Positive predictors associated with SARS-CoV-2 vaccine acceptance were an age older than 40 years, a higher educational level, history of influenza vaccination within the previous year, having an obstetrician as the primary healthcare practitioner, and being in their third trimester of pregnancy. After the first pandemic wave, Switzerland had a low SARS-CoV-2 vaccination acceptance rate, emphasizing the need to identify and reduce barriers for immunization in pregnant and breastfeeding women, particularly among the youngest and those with a lower educational level. Full article

(This article belongs to the Special Issue Emerging Virus Infections in Adverse Pregnancy Outcomes)

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11 pages, 472 KiB

Open AccessArticle

Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study

by Sara Cruz Melguizo, María Luisa de la Cruz Conty, Paola Carmona Payán, Alejandra Abascal-Saiz, Pilar Pintando Recarte, Laura González Rodríguez, Celia Cuenca Marín, Alicia Martínez Varea, Ana Belén Oreja Cuesta, Pilar Prats Rodríguez, Irene Fernández Buhigas, María Victoria Rodríguez Gallego, Ana María Fernández Alonso, Rocío López Pérez, José Román Broullón Molanes, María Begoña Encinas Pardilla, Mercedes Ramírez Gómez, María Joaquina Gimeno Gimeno, Antonio Sánchez Muñoz, Oscar Martínez-Pérez and on behalf of the Spanish Obstetric Emergency Group (S.O.E.G.) Show full author list Hide full author list

Viruses 2021, 13(5), 853; https://doi.org/10.3390/v13050853 - 07 May 2021

Cited by 35 | Viewed by 4456

Abstract

Pregnant women who are infected with SARS-CoV-2 are at an increased risk of adverse perinatal outcomes. With this study, we aimed to better understand the relationship between maternal infection and perinatal outcomes, especially preterm births, and the underlying medical and interventionist factors. This [...] Read more.

Pregnant women who are infected with SARS-CoV-2 are at an increased risk of adverse perinatal outcomes. With this study, we aimed to better understand the relationship between maternal infection and perinatal outcomes, especially preterm births, and the underlying medical and interventionist factors. This was a prospective observational study carried out in 78 centers (Spanish Obstetric Emergency Group) with a cohort of 1347 SARS-CoV-2 PCR-positive pregnant women registered consecutively between 26 February and 5 November 2020, and a concurrent sample of PCR-negative mothers. The patients’ information was collected from their medical records, and the association of SARS-CoV-2 and perinatal outcomes was evaluated by univariable and multivariate analyses. The data from 1347 SARS-CoV-2-positive pregnancies were compared with those from 1607 SARS-CoV-2-negative pregnancies. Differences were observed between both groups in premature rupture of membranes (15.5% vs. 11.1%, p < 0.001); venous thrombotic events (1.5% vs. 0.2%, p < 0.001); and severe pre-eclampsia incidence (40.6 vs. 15.6%, p = 0.001), which could have been overestimated in the infected cohort due to the shared analytical signs between this hypertensive disorder and COVID-19. In addition, more preterm deliveries were observed in infected patients (11.1% vs. 5.8%, p < 0.001) mainly due to an increase in iatrogenic preterm births. The prematurity in SARS-CoV-2-affected pregnancies results from a predisposition to end the pregnancy because of maternal disease (pneumonia and pre-eclampsia, with or without COVID-19 symptoms). Full article

(This article belongs to the Special Issue Emerging Virus Infections in Adverse Pregnancy Outcomes)

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13 pages, 10753 KiB

Open AccessArticle

SARS-CoV-2 and Placenta: New Insights and Perspectives

by Leonardo Resta, Antonella Vimercati, Gerardo Cazzato, Giulia Mazzia, Ettore Cicinelli, Anna Colagrande, Margherita Fanelli, Sara Vincenza Scarcella, Oronzo Ceci and Roberta Rossi

Viruses 2021, 13(5), 723; https://doi.org/10.3390/v13050723 - 21 Apr 2021

Cited by 37 | Viewed by 3450

Abstract

The study of SARS-CoV-2 positive pregnant women is of some importance for gynecologists, obstetricians, neonatologists and women themselves. In recent months, new works have tried to clarify what happens at the fetal–placental level in women positive for the virus, and different pathogenesis mechanisms [...] Read more.

The study of SARS-CoV-2 positive pregnant women is of some importance for gynecologists, obstetricians, neonatologists and women themselves. In recent months, new works have tried to clarify what happens at the fetal–placental level in women positive for the virus, and different pathogenesis mechanisms have been proposed. Here, we present the results of a large series of placentas of Coronavirus disease (COVID) positive women, in a reference center for COVID-positive pregnancies, on which we conducted histological, immunohistochemical and electron microscopy investigations. A case–control study was conducted in order to highlight any histopathological alterations attributable to SARS-CoV-2. The prevalence of maternal vascular malperfusion was not significantly different between cases and controls (54.3% vs. 43.7% p = 0.19), whereas the differences with regard to fetal vascular malperfusion (21.1% vs. 4.2% p < 0.001) were significant. More frequent in cases with respect to controls were decidual arteriopathy (40.9% vs. 1.4% p < 0.0001), decidual inflammation (32.4% vs. 0.7% p < 0.0001), perivillous fibrin deposition (36.6% vs. 3.5% p < 0.0001) and fetal vessel thrombi (22.5% vs. 0.7% p < 0.0001). No significant differences in the percentage of terminal villous hyperplasia and chorioamnionitis were observed between the two groups. As the pandemic continues, these studies will become more urgent in order to clarify the possible mechanism of maternal–fetal transmission of the virus. Full article

(This article belongs to the Special Issue Emerging Virus Infections in Adverse Pregnancy Outcomes)

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14 pages, 557 KiB

Open AccessArticle

Maternal Infection and Adverse Pregnancy Outcomes among Pregnant Travellers: Results of the International Zika Virus in Pregnancy Registry

by Manon Vouga, Léo Pomar, Antoni Soriano-Arandes, Carlota Rodó, Anna Goncé, Eduard Gratacos, Audrey Merriam, Isabelle Eperon, Begoña Martinez De Tejada, Béatrice Eggel, Sophie Masmejan, Laurence Rochat, Blaise Genton, Tim Van Mieghem, Véronique Lambert, Denis Malvy, Patrick Gérardin, David Baud and Alice Panchaud

Viruses 2021, 13(2), 341; https://doi.org/10.3390/v13020341 - 22 Feb 2021

Cited by 2 | Viewed by 2302

Abstract

In this multicentre cohort study, we evaluated the risks of maternal ZIKV infections and adverse pregnancy outcomes among exposed travellers compared to women living in areas with ZIKV circulation (residents). The risk of maternal infection was lower among travellers compared to residents: 25.0% [...] Read more.

In this multicentre cohort study, we evaluated the risks of maternal ZIKV infections and adverse pregnancy outcomes among exposed travellers compared to women living in areas with ZIKV circulation (residents). The risk of maternal infection was lower among travellers compared to residents: 25.0% (n = 36/144) versus 42.9% (n = 309/721); aRR 0.6; 95% CI 0.5–0.8. Risk factors associated with maternal infection among travellers were travelling during the epidemic period (i.e., June 2015 to December 2016) (aOR 29.4; 95% CI 3.7–228.1), travelling to the Caribbean Islands (aOR 3.2; 95% CI 1.2–8.7) and stay duration >2 weeks (aOR 8.7; 95% CI 1.1–71.5). Adverse pregnancy outcomes were observed in 8.3% (n = 3/36) of infected travellers and 12.7% (n = 39/309) of infected residents. Overall, the risk of maternal infections is lower among travellers compared to residents and related to the presence of ongoing outbreaks and stay duration, with stays <2 weeks associated with minimal risk in the absence of ongoing outbreaks. Full article

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Review

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22 pages, 1403 KiB

Open AccessReview

The Current Evidence Regarding COVID-19 and Pregnancy: Where Are We Now and Where Should We Head to Next?

by Theodoros Kalampokas, Anna Rapani, Maria Papageorgiou, Sokratis Grigoriadis, Evangelos Maziotis, George Anifandis, Olga Triantafyllidou, Despoina Tzanakaki, Spyridoula Neofytou, Panagiotis Bakas, Mara Simopoulou and Nikolaos Vlahos

Viruses 2021, 13(10), 2000; https://doi.org/10.3390/v13102000 - 05 Oct 2021

Cited by 6 | Viewed by 3352

Abstract

Despite the volume of publications dedicated to unraveling the biological characteristics and clinical manifestations of SARS-CoV-2, available data on pregnant patients are limited. In the current review of literature, we present an overview on the developmental course, complications, and adverse effects of COVID-19 [...] Read more.

Despite the volume of publications dedicated to unraveling the biological characteristics and clinical manifestations of SARS-CoV-2, available data on pregnant patients are limited. In the current review of literature, we present an overview on the developmental course, complications, and adverse effects of COVID-19 on pregnancy. A comprehensive review of the literature was performed in PubMed/Medline, Embase, and Cochrane Central databases up to June 2021. This article collectively presents what has been so far reported on the identified critical aspects, namely complications during pregnancy, delivery challenges, neonatal health care, potential routes of viral transmission, including vertical transmission or breastfeeding, along with the risks involved in the vaccination strategy during pregnancy. Despite the fact that we are still largely navigating uncharted territory, the observed publication explosion in the field is unprecedented. The overwhelming need for data is undoubtable, and this serves as the driver for the plethora of publications witnessed. Nonetheless, the quality of data sourced is variable. In the midst of the frenzy for reporting on SARS-CoV-2 data, monitoring this informational overload is where we should head to next, considering that poor quality research may in fact hamper our attempts to prevail against this unparalleled pandemic outbreak. Full article

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Other

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11 pages, 1517 KiB

Open AccessCase Report

Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury

by Guillaume Favre, Sara Mazzetti, Carole Gengler, Claire Bertelli, Juliane Schneider, Bernard Laubscher, Romina Capoccia, Fatemeh Pakniyat, Inès Ben Jazia, Béatrice Eggel-Hort, Laurence de Leval, Léo Pomar, Gilbert Greub, David Baud and Eric Giannoni

Viruses 2021, 13(12), 2517; https://doi.org/10.3390/v13122517 - 15 Dec 2021

Cited by 26 | Viewed by 3639

Abstract

Neonatal COVID-19 is rare and mainly results from postnatal transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), however, can infect the placenta and compromise its function. We present two cases of decreased fetal movements and abnormal fetal heart rhythm 5 days after mild [...] Read more.

Neonatal COVID-19 is rare and mainly results from postnatal transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), however, can infect the placenta and compromise its function. We present two cases of decreased fetal movements and abnormal fetal heart rhythm 5 days after mild maternal COVID-19, requiring emergency caesarean section at 29 + 3 and 32 + 1 weeks of gestation, and leading to brain injury. Placental examination revealed extensive and multifocal chronic intervillositis, with intense cytoplasmic positivity for SARS-CoV-2 spike antibody and SARS-CoV-2 detection by RT-qPCR. Vertical transmission was confirmed in one case, and both neonates developed extensive cystic peri-ventricular leukomalacia. Full article

(This article belongs to the Special Issue Emerging Virus Infections in Adverse Pregnancy Outcomes)

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11 pages, 1164 KiB

Open AccessBrief Report

Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19

by Salvador Espino-y-Sosa, Raigam Jafet Martinez-Portilla, Johnatan Torres-Torres, Juan Mario Solis-Paredes, Guadalupe Estrada-Gutierrez, Jose Antonio Hernandez-Pacheco, Aurora Espejel-Nuñez, Paloma Mateu-Rogell, Angeles Juarez-Reyes, Francisco Eduardo Lopez-Ceh, Jose Rafael Villafan-Bernal, Lourdes Rojas-Zepeda, Iris Paola Guzman-Guzman and Liona C. Poon

Viruses 2021, 13(10), 1906; https://doi.org/10.3390/v13101906 - 23 Sep 2021

Cited by 23 | Viewed by 4325

Abstract

Background: In healthy pregnancies, components of the Renin-Angiotensin system (RAS) are present in the placental villi and contribute to invasion, migration, and angiogenesis. At the same time, soluble fms-like tyrosine kinase 1 (sFlt-1) production is induced after binding of ANG-II to its receptor [...] Read more.

Background: In healthy pregnancies, components of the Renin-Angiotensin system (RAS) are present in the placental villi and contribute to invasion, migration, and angiogenesis. At the same time, soluble fms-like tyrosine kinase 1 (sFlt-1) production is induced after binding of ANG-II to its receptor (AT-1R) in response to hypoxia. As RAS plays an essential role in the pathogenesis of COVID-19, we hypothesized that angiogenic marker (sFlt-1) and RAS components (ANG-II and ACE-2) may be related to adverse outcomes in pregnant women with COVID-19; Methods: Prospective cohort study. Primary outcome was severe pneumonia. Secondary outcomes were ICU admission, intubation, sepsis, and death. Spearman’s Rho test was used to analyze the correlation between sFlt-1 and ANG-II levels. The sFlt-1/ANG-II ratio was determined and the association with each adverse outcome was explored by logistic regression analysis and the prediction was assessed using receiver-operating-curve (ROC); Results: Among 80 pregnant women with COVID-19, the sFlt-1/ANG-II ratio was associated with an increased probability of severe pneumonia (odds ratio [OR]: 1.31; p = 0.003), ICU admission (OR: 1.05; p = 0.007); intubation (OR: 1.09; p = 0.008); sepsis (OR: 1.04; p = 0.008); and death (OR: 1.04; p = 0.018); Conclusion: sFlt-1/ANG-II ratio is a good predictor of adverse events such as pneumonia, ICU admission, intubation, sepsis, and death in pregnant women with COVID-19. Full article

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2 pages, 185 KiB

Open AccessReply

Current Data on COVID-19 mRNA-Vaccine Safety during Pregnancy Might Be Subject to Selection Bias. Reply to Stroobandt, S.; Stroobandt, R. Data of the COVID-19 mRNA-Vaccine V-Safe Surveillance System and Pregnancy Registry Reveals Poor Embryonic and Second Trimester Fetal Survival Rate. Comment on “Stuckelberger et al. SARS-CoV-2 Vaccine Willingness among Pregnant and Breastfeeding Women during the First Pandemic Wave: A Cross-Sectional Study in Switzerland. Viruses 2021, 13, 1199”

by Sarah Stuckelberger, Guillaume Favre, Michael Ceulemans, Eva Gerbier, Valentine Lambelet, Milos Stojanov, Ursula Winterfeld, David Baud, Alice Panchaud and Léo Pomar

Viruses 2021, 13(8), 1546; https://doi.org/10.3390/v13081546 - 05 Aug 2021

Cited by 2 | Viewed by 4752

Abstract

We would like to thank Stroobandt, S. and Stroobandt, R. for showing interest in our paper [...] Full article

(This article belongs to the Special Issue Emerging Virus Infections in Adverse Pregnancy Outcomes)

2 pages, 149 KiB

Open AccessComment

Data of the COVID-19 mRNA-Vaccine V-Safe Surveillance System and Pregnancy Registry Reveals Poor Embryonic and Second Trimester Fetal Survival Rate. Comment on Stuckelberger et al. SARS-CoV-2 Vaccine Willingness among Pregnant and Breastfeeding Women during the First Pandemic Wave: A Cross-Sectional Study in Switzerland. Viruses 2021, 13, 1199

by Serge Stroobandt and Roland Stroobandt

Viruses 2021, 13(8), 1545; https://doi.org/10.3390/v13081545 - 05 Aug 2021

Cited by 3 | Viewed by 4598

Abstract

Dr. Sarah Stuckelberger and her colleagues should be commended for their cross-sectional study assessing the willingness of Swiss pregnant and breastfeeding women to be vaccinated against SARS-CoV-2 [...] Full article

(This article belongs to the Special Issue Emerging Virus Infections in Adverse Pregnancy Outcomes)

7 pages, 4300 KiB

Open AccessCase Report

Is the First of the Two Born Saved? A Rare and Dramatic Case of Double Placental Damage from SARS-CoV-2

by Leonardo Resta, Antonella Vimercati, Sara Sablone, Andrea Marzullo, Gerardo Cazzato, Giuseppe Ingravallo, Giulia Mazzia, Francesca Arezzo, Anna Colagrande and Roberta Rossi

Viruses 2021, 13(6), 995; https://doi.org/10.3390/v13060995 - 26 May 2021

Cited by 8 | Viewed by 2265

Abstract

The current coronavirus pandemic has affected, in a short time, various and different areas of medicine. Among these, the obstetric field has certainly been touched in full, and the knowledge of the mechanisms potentially responsible for placental damage from SARS-CoV-2 occupy a certain [...] Read more.

The current coronavirus pandemic has affected, in a short time, various and different areas of medicine. Among these, the obstetric field has certainly been touched in full, and the knowledge of the mechanisms potentially responsible for placental damage from SARS-CoV-2 occupy a certain importance. Here we present here a rare case of dichorionic twins born at 30 weeks and 4 days of amenorrhea, one of whom died in the first few hours of life after placental damages potentially related to SARS-CoV-2. We also propose a brief review of the current literature giving ample emphasis to similar cases described. Full article

(This article belongs to the Special Issue Emerging Virus Infections in Adverse Pregnancy Outcomes)

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11 pages, 1817 KiB

Open AccessCase Report

Vertical Transmission of SARS-CoV-2 in Second Trimester Associated with Severe Neonatal Pathology

by Gennady Sukhikh, Ulyana Petrova, Andrey Prikhodko, Natalia Starodubtseva, Konstantin Chingin, Huanwen Chen, Anna Bugrova, Alexey Kononikhin, Olga Bourmenskaya, Alexander Brzhozovskiy, Evgeniya Polushkina, Galina Kulikova, Alexander Shchegolev, Dmitry Trofimov, Vladimir Frankevich, Evgeny Nikolaev and Roman G. Shmakov

Viruses 2021, 13(3), 447; https://doi.org/10.3390/v13030447 - 10 Mar 2021

Cited by 31 | Viewed by 7397

Abstract

The effects of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in women on the gestation course and the health of the fetus, particularly in the first and second trimesters, remain very poorly explored. This report describes a case in which the normal development [...] Read more.

The effects of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in women on the gestation course and the health of the fetus, particularly in the first and second trimesters, remain very poorly explored. This report describes a case in which the normal development of pregnancy was complicated immediately after the patient had experienced Coronavirus disease 2019 (COVID-19) at the 21st week of gestation. Specific conditions included critical blood flow in the fetal umbilical artery, fetal growth restriction (1st percentile), right ventricular hypertrophy, hydropericardium, echo-characteristics of hypoxic-ischemic brain injury (leukomalacia in periventricular area) and intraventricular hemorrhage at the 25th week of gestation. Premature male neonate delivered at the 26th week of gestation died after 1 day 18 h due to asystole. The results of independent polymerase chain reaction (PCR), mass spectrometry and immunohistochemistry analyses of placenta tissue, umbilical cord blood and child blood jointly indicated vertical transmission of SARS–CoV-2 from mother to the fetus, which we conclude to be the major cause for the development of maternal vascular malperfusion in the studied case. Full article

(This article belongs to the Special Issue Emerging Virus Infections in Adverse Pregnancy Outcomes)

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