Population Genomics of Human Viruses 2023

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".

Deadline for manuscript submissions: closed (29 December 2023) | Viewed by 1154

Special Issue Editors

Scientific Insitute IRCCS Eugenio Medea, Bosisio Parini, Italy
Interests: human virus evolution; virus population genetics; geographic structure of viral populations; virus origin; arenavirus genetic diversity; herpesvirus genetics; coronavirus evolution
Special Issues, Collections and Topics in MDPI journals
Scientific Insitute IRCCS Eugenio Medea, Bosisio Parini, Italy
Interests: host-pathogen interactions; pathogenic potential of human viruses; human virus evolution; coronavirus genetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, the advent of high-throughput sequencing approaches and the parallel increase in the sophistication and quality of computational tools for storing and mining large sequence datasets have greatly enhanced our ability to genetically characterize viral populations. The enormous potential of these developments has become more than clear during the SARS-CoV-2 pandemic, but the large-scale sequencing of other human viruses has also provided invaluable information about their epidemiology and evolutionary dynamics. It is thus becoming evident that the genetic diversity of viral populations is determined by viral intrinsic features, but also influenced by host factors, by human population interactions among themselves, and by anthropic changes to the natural environment.

This Special Issue “Population Genomics of Human Viruses”, is intended for original papers and reviews that further our insight into human virus genetic diversity, evolution, and ecology using population genomics approaches. Computational tools to characterize viral populations, track their spread and analyze their spatial/temporal structure will also be welcome, together with original databases of viral genome diversity and relevant metadata. 

Dr. Manuela Sironi
Dr. Rachele Cagliani
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • human viruses
  • viral populations
  • evolutionary genomics
  • virus genetic diversity
  • spatial/temporal population structure
  • computational tools
  • epidemiology
  • viral ecology

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Published Papers (1 paper)

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Research

18 pages, 3946 KiB  
Article
Genomic Expedition: Deciphering Human Adenovirus Strains from the 2023 Outbreak in West Bengal, India: Insights into Viral Evolution and Molecular Epidemiology
by Ananya Chatterjee, Uttaran Bhattacharjee, Rudrak Gupta, Ashis Debnath, Agniva Majumdar, Ritubrita Saha, Mamta Chawla-Sarkar, Alok Kumar Chakrabarti and Shanta Dutta
Viruses 2024, 16(1), 159; https://doi.org/10.3390/v16010159 - 21 Jan 2024
Viewed by 839
Abstract
Understanding the genetic dynamics of circulating Human Adenovirus (HAdV) types is pivotal for effectively managing outbreaks and devising targeted interventions. During the West Bengal outbreak of 2022–2023, an investigation into the genetic characteristics and outbreak potential of circulating HAdV types was conducted. Twenty-four [...] Read more.
Understanding the genetic dynamics of circulating Human Adenovirus (HAdV) types is pivotal for effectively managing outbreaks and devising targeted interventions. During the West Bengal outbreak of 2022–2023, an investigation into the genetic characteristics and outbreak potential of circulating HAdV types was conducted. Twenty-four randomly selected samples underwent whole-genome sequencing. Analysis revealed a prevalent recombinant strain, merging type 3 and type 7 of human mastadenovirus B1 (HAd-B1) species, indicating the emergence of recent strains of species B in India. Furthermore, distinctions in VA-RNAs and the E3 region suggested that current circulating strains of human mastadenovirus B1 (HAd-B1) possess the capacity to evade host immunity, endure longer within hosts, and cause severe respiratory infections. This study underscores the significance of evaluating the complete genome sequence of HAdV isolates to glean insights into their outbreak potential and the severity of associated illnesses. Full article
(This article belongs to the Special Issue Population Genomics of Human Viruses 2023)
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