Strategies for Eliminating Neglected Tropical Viral Diseases

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".

Deadline for manuscript submissions: 20 June 2024 | Viewed by 1708

Special Issue Editor


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Guest Editor
1. Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA
2. Department of Medicine, Division of Infectious Diseases, Oregon Health and Science University, Portland, OR 97239, USA
3. Program in Epidemiology, OHSU-PSU School of Public Health, Oregon Health and Science University, Portland, OR 97239, USA
Interests: flaviviruses; arboviruses; vaccines; antibodies; memory B cells; clinical infectious disease; infectious disease ecology

Special Issue Information

Dear Colleagues,

Neglected tropical viral diseases encompass arthropod-borne and other zoonotic illnesses with incidence and prevalence that range from rare and sporadic to epidemic and endemic. While for each disease there are specific measures and interventions that may be needed to control or eliminate that specific disease, the overarching goal of reducing the impact neglected tropical viral diseases will require multifaceted approaches that combine individual, community level, population level, and environmental-based strategies that combine to minimize, if not eliminate, exposure to, susceptibility to, and illness from infection with these viruses. This Special Issue of Viruses on “Strategies for Eliminated Neglected Tropical Viral Diseases” will include review articles or papers that have, as an ultimate goal, the providing of:

  • General background on the elimination of neglected tropical viral diseases in either humans or other animals.
  • Vaccine refinement, design, and deployment strategies for the elimination of neglected tropical diseases.
  • Modification of the human-environment interface to eliminate or control neglected tropical diseases:
    • Agricultural or harvesting activities;
    • Landscape incursion and modification for housing or agriculture;
    • The built environment.
  • Vector and vertebrate reservoir control for control or elimination of neglected tropical viral diseases.
  • Therapeutic strategies to control or eliminate neglected tropical viral diseases.
  • Knowledge, attitudes, and practices that can contribute to control or elimination of neglected tropical viral diseases.
  • The impact of social and/or economic reform on control or elimination of neglected tropical viral diseases.
  • The impact of climate change on the control or elimination of neglected tropical viral diseases.

Dr. William Messer
Guest Editor

Manuscript Submission Information

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Keywords

  • neglected tropical viral diseases
  • viral vaccines
  • vector control
  • reservoir control
  • knowledge attitudes and practice
  • the built environment
  • climate change
  • antiviral therapy

Published Papers (1 paper)

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Research

20 pages, 10903 KiB  
Article
Characterisation of a Live-Attenuated Rabies Virus Expressing a Secreted scFv for the Treatment of Rabies
by Samuel P. Smith, Rebecca Shipley, Pascal Drake, Anthony R. Fooks, Julian Ma and Ashley C. Banyard
Viruses 2023, 15(8), 1674; https://doi.org/10.3390/v15081674 - 31 Jul 2023
Cited by 2 | Viewed by 1368
Abstract
Rabies virus (RABV) causes possibly the oldest disease and is responsible for an estimated >59,000 human fatalities/year. Post exposure prophylaxis (PEP), the administration of vaccine and rabies immunoglobulin, is a highly effective tool which is frequently unavailable in RABV endemic areas. Furthermore, due [...] Read more.
Rabies virus (RABV) causes possibly the oldest disease and is responsible for an estimated >59,000 human fatalities/year. Post exposure prophylaxis (PEP), the administration of vaccine and rabies immunoglobulin, is a highly effective tool which is frequently unavailable in RABV endemic areas. Furthermore, due to the constraints of the blood-brain barrier, current PEP regimes are ineffective after the onset of clinical symptoms which invariably result in death. To circumvent this barrier, a live-attenuated recombinant RABV expressing a highly RABV-neutralising scFv antibody (62-71-3) linked to the fluorescent marker mCherry was designed. Once rescued, the resulting construct (named RABV-62scFv) was grown to high titres, its growth and cellular dissemination kinetics characterised, and the functionality of the recombinant 62-71-3 scFv assessed. Encouraging scFv production and subsequent virus neutralisation results demonstrate the potential for development of a therapeutic live-attenuated virus-based post-infection treatment (PIT) for RABV infection. Full article
(This article belongs to the Special Issue Strategies for Eliminating Neglected Tropical Viral Diseases)
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