Innate and Adaptive Immunity to Cutaneous Virus Infection
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".
Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1046
Special Issue Editor
Special Issue Information
Dear Colleagues,
The skin is the largest contiguous organ in the body, and, as the organ with the largest environmentally exposed surface area, is a crucial defensive barrier against the invasion of pathogens. A number of viruses infect through microabrasions in the epidermal barrier, while others are transmitted by insect vectors into the skin. The diversity of cutaneous virus infections is increased by a division into two general strategies: There are viruses that cause, and try to partially evade, a large inflammatory and adaptive immune response while spreading elsewhere in the body. These viruses can produce a virulent reaction in the skin, damaging the barrier function and potentially allowing secondary infections. Conversely, there are viruses that attempt to infect the outermost layer of the epidermis and remain as immunologically silent as possible. These viruses often remain latent in the skin, but can then induce tumor formation at a much later time point. The local cutaneous immune system must be specialized to respond to each mode of transmission and infection, while minimizing damage to the barrier function of the skin. Skin pathologies will often reduce the effectiveness of cutaneous antiviral responses, promoting virus growth as well as spread and reducing barrier function; however, while many studies have focused on responses to cutaneous virus infections, we feel that a Special Issue dedicated to these responses may reveal common, as well as virus-specific, components of the cutaneous antiviral response.
In this Special Issue, we welcome the submission of a wide range of articles, including original research, short communications, and reviews, that focus on the innate, primary, or memory adaptive immune response to cutaneous virus infections. Articles could focus on cell-type specializations in the skin, novel effector mechanisms displayed in the skin, the recognition and elimination of virus-induced cutaneous tumors, and mechanisms deployed to avoid damage to the skin barrier function.
Dr. Christopher C. Norbury
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cutaneous/skin
- virus
- interferon
- T cell
- dendritic cell
- monocyte
- keratinocyte
- poxvirus
- herpes simplex virus
- papilloma virus
- merkel cell polyomavirus
- antimicrobial peptides
