Special Issue "In Memory of Stefan Kunz"
Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 38660
A printed edition of this Special Issue is available here.
Interests: viral pathogenesis; immune responses to viral infections; autoimmune diseases; history of viral plagues and their control
* Emeritus Professor Department of Immunology and Microbiology; Founder of the Laboratory of Virus-Immunobiology; Elected Member U.S.A. National Academy of Sciences, and National Academy of Medicine; Author of Viruses, Plagues and History [Oxford Press]
Interests: molecular, cell biology and pathogenesis of mammarenaviruses; virus-host cell interactions; antivirals; live attenuated vaccines
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Stefan Kunz was a dear scientific colleague and friend that passed away too early in life. During his scientific career, Stefan made major contributions to the field of virology, working on how mammarenaviruses gain access to their target cells. Stefan made seminal contributions to the structural basis and molecular interactions between Old World mammarenaviruses Lassa virus (LASV) and lymphocytic choriomeningitis virus (LCMV) and their cell entry receptor alpha-dystroglycan (a-DG).
LASV is an important human pathogen, whereas LCMV provides investigators with a highly tractable experimental system for the investigation of virus–host interactions and associated disease. LASV is the causative agent of Lassa fever (LF), a viral hemorrhagic fever (HF) disease endemic to Western Africa where the virus infects hundreds of thousands of individuals yearly, resulting in a high number of LF cases that are associated with high morbidity and a high case fatality rate among hospitalized patients. LCMV has been a Rosetta Stone in the fields of viral immunology and pathogenesis, including the investigation of virus persistence, T cell responses, T cell exhaustion, and virus-induced autoimmune diseases. In addition to his discoveries in the area of mammarenavirus cell entry, Stefan made also important contributions to our understanding of the processing of the virus glycoprotein precursor (GPC) by the cellular protease subtilisin kexin isozyme-1/site-1 protease (SKI-1/S1P), which is a critical step in the completion of the mammarenavirus life cycle. Works by Stefan uncovered that targeting the activity of the SKI-1/S1P protease represents a very attractive antiviral strategy against human pathogenic mammarenaviruses.
This Special Issue of Viruses contains articles by those who knew and worked with Stefan and will cover different aspects of the basic molecular and cell biology of the mammarenavirus life cycle and the implications for the development of antiviral strategies. Stefan’s numerous high-quality publications speak of his talent for research, but they do not capture his also great human qualities and collegiality. Those of us who worked with Stefan will miss his generosity in sharing reagents and methods, and disposition, which included sharing new ideas and participating in collaborative research studies.
Dr. Juan De la Torre
Prof. Dr. Michael B.A. Oldstone
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.