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Viruses
Special Issues
STING-Mediated Antiviral Activity and Viral Evasion
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STING-Mediated Antiviral Activity and Viral Evasion

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 2358

Special Issue Editors

Dr. Yanmin Li

E-Mail Website
Guest Editor
College of Animal Husbandry and Veterinary Medicine, Southwest University for Nationalities, Chengdu 610041, China
Interests: viral infection; innate immunity; diagnostic assay; animals; pathogenesis of viral diseases; vaccine
Special Issues, Collections and Topics in MDPI journals
Dr. Zhidong Zhang

E-Mail Website
Guest Editor
College of Animal Husbandry and Veterinary Medicine, Southwest University for Nationalities, Chengdu 610041, China
Interests: pathogenesis of viral diseases; interaction of a virus with host; diagnostic assay
Special Issues, Collections and Topics in MDPI journals
Dr. Xiaodong Qin

E-Mail Website
Guest Editor
Chinese Academy of Agricultural Sciences, Beijing 100081, China
Interests: viral infection; innate immunity; diagnostic assay; animals; pathogenesis of viral diseases; vaccine

Special Issue Information

Dear Colleagues,

A stimulator of interferon genes (STING) is a transmembrane protein on the endoplasmic reticulum. It is not only an essential regulator of innate immunity in relation to infection with DNA viruses by sensing viral DNA via the cGAS-STING pathway, but also plays a fundamental role in responses against RNA viruses by regulating autophagy, cellular translation machinery, and the crosstalk with RNA RLRs (RIG-I and MDA5). However, numerous factors, particularly viral factors that dysregulate STING and its dependent pathway network, have been shown to help viruses to escape innate immune response to benefit the survival of viruses. Therefore, STING is a signaling hub in innate immunity against viral infection and the activation of STING pathway may provide a new therapeutic approach to fighting against infections with viruses. A better understanding of the regulating mechanisms and signaling pathways of STING associated with innate immunity to viral infection can shed light on new targets for novel antiviral therapeutics and vaccines. This Special Issue is intended to highlight novel findings related to STING and its pathway network in regulating viral replication, antiviral immunity, and cell death, as well as the development of novel broadly antiviral drugs and vaccines.

Dr. Yanmin Li
Dr. Zhidong Zhang
Dr. Xiaodong Qin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • STING
  • viral infection
  • innate immunity
  • antiviral
  • viral evasion

Published Papers (2 papers)

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Research

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13 pages, 2985 KiB  
Article
A Non-Nucleotide STING Agonist MSA-2 Synergized with Manganese in Enhancing STING Activation to Elicit Potent Anti-RNA Virus Activity in the Cells
by Hanrui Lin, Rui Zhang, Hanyi Xiang, Xinqian Lin, Xiongting Huang, Jingsong Chen, Long Zhou, Zhidong Zhang and Yanmin Li
Viruses 2023, 15(11), 2138; https://doi.org/10.3390/v15112138 - 24 Oct 2023
Cited by 1 | Viewed by 1110
Abstract
Both Manganese (Mn2+) and MSA-2 can activate the downstream signal pathway through stimulator of interferon genes (STING) and induce the expression of type I interferon, which is important for hosts to protect against DNA viruses. However, its effect on RNA viruses [...] Read more.
Both Manganese (Mn2+) and MSA-2 can activate the downstream signal pathway through stimulator of interferon genes (STING) and induce the expression of type I interferon, which is important for hosts to protect against DNA viruses. However, its effect on RNA viruses remains unknown. In this study, we used Seneca Valley virus (SVV) as a model RNA virus to investigate the inhibitory effects of Mn2+ and MSA-2 on the virus replication in the porcine cells (PK-15 cells). The results showed that both MSA-2 and Mn2+ were able to inhibit the SVV replication in PK-15 cells. The combination of MAS-2 and Mn2+ could confer better protection against SVV. Further studies showed that MSA-2 and Mn2+ could activate TBK1, IRF3 and NFκB through STING and induce the expression of IFN-β, IL-6 and TNF-α. The present study confirmed that MSA-2 synergized with Mn2+ in STING activation to generate a better antiviral effect in vitro, which would be helpful for the further development of effective antiviral drugs in the future. Full article
(This article belongs to the Special Issue STING-Mediated Antiviral Activity and Viral Evasion)
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Review

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32 pages, 1119 KiB  
Review
STINGing Defenses: Unmasking the Mechanisms of DNA Oncovirus-Mediated Immune Escape
by Mayra F Martínez-López, Claire Muslin and Nikolaos C. Kyriakidis
Viruses 2024, 16(4), 574; https://doi.org/10.3390/v16040574 - 09 Apr 2024
Viewed by 766
Abstract
DNA oncoviruses represent an intriguing subject due to their involvement in oncogenesis. These viruses have evolved mechanisms to manipulate the host immune response, facilitating their persistence and actively contributing to carcinogenic processes. This paper describes the complex interactions between DNA oncoviruses and the [...] Read more.
DNA oncoviruses represent an intriguing subject due to their involvement in oncogenesis. These viruses have evolved mechanisms to manipulate the host immune response, facilitating their persistence and actively contributing to carcinogenic processes. This paper describes the complex interactions between DNA oncoviruses and the innate immune system, with a particular emphasis on the cGAS-STING pathway. Exploring these interactions highlights that DNA oncoviruses strategically target and subvert this pathway, exploiting its vulnerabilities for their own survival and proliferation within the host. Understanding these interactions lays the foundation for identifying potential therapeutic interventions. Herein, we sought to contribute to the ongoing efforts in advancing our understanding of the innate immune system in oncoviral pathogenesis. Full article
(This article belongs to the Special Issue STING-Mediated Antiviral Activity and Viral Evasion)
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