The Role of Cell Death in Viral Infections
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "General Virology".
Deadline for manuscript submissions: 31 October 2024 | Viewed by 326
Special Issue Editor
Interests: respiratory viruses; innate immune signalling; innate immune evasion; host-virus interactions; virus transmission
Special Issue Information
Dear Colleagues,
Programmed cell death is a key component of the host’s innate immune response and serves to limit the spread of infection and tissue damage. Viruses have therefore evolved many mechanisms for modulating cell death pathways. Viral gene products may interfere with effector or regulatory mechanisms to confer a selective advantage to the virus by suppressing cell death and therefore promoting replication and spread. Other viruses do not suppress cell death but rather hijack cell death pathways to compromise the host. Apoptosis, pyroptosis and necroptosis are the most widely studied pathways of programmed cell death in response to virus infection. During apoptosis, the cell membrane remains intact and allows neighboring immune cells to remove both the cell and the invading virus. However, pyroptosis and necroptosis are lytic cell death processes, which facilitate the release of damage-associated molecular patterns (DAMPS) into the extracellular space, thus inducing an inflammatory response. However, these pathways are not necessarily discrete and may intersect during infection, increasing the complexity of virus–host interaction. Understanding this relationship will provide us with insights and novel approaches for antiviral therapies.
For this Special Issue, we invite the submission of original research papers and review articles pertaining to programmed cell death pathways in viral infection, virus–host interaction, the effect this has on disease, and ideas for novel therapeutics based on new knowledge in this area.
Prof. Kirsten Spann
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- programmed cell death
- inflammation
- cellular damage
- virus–host interactions
- antiviral therapies
