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Special Issue "The Regulatory Mechanism of Nutrient Metabolism on Porcine Intestinal Health"

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A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Nutritional and Metabolic Diseases in Veterinary Medicine".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 7307

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Special Issue Editor

Dr. Jinbiao Zhao

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Guest Editor

College of Animal Science and Feed Technology, China Agricultural University, Beijing 100193, China
Interests: pig nutrition; intestinal health; gut microbiota

Special Issue Information

Dear Colleagues,

Problems such as the emergence of drug-resistant genes and food safety, caused by the overuse of antibiotics, are becoming increasingly prominent. Dietary nutrients can replace antibiotics for killing pathogens effectively and enhancing the immune functions of the host, and it is not easy to produce drug resistance genes. However, the potential mechanisms of dietary nutrient metabolism are vague; thus, there is an urgent need to explore the potential mechanisms of dietary nutrients on regulating host health. Furthermore, different sources of nutrients have diverse responses on the intestinal barrier function of the host. It is vital to distinguish the specific effects of different nutrient metabolism mechanisms on intestinal health.

The objective of this proposed Special Issue on “The Regulatory Mechanism of Nutrient Metabolism on Porcine Intestinal Health” is to publish meaningful papers pertaining to the interactions between nutrient metabolism and intestinal health. In particular, papers (reviews and/or clinical or experimental studies) dealing with the role of dietary nutrients in the regulation of intestinal health will be included.

Dr. Jinbiao Zhao
Guest Editor

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Keywords

antibiotics
intestinal health
microbiota community
nutrients
prebiotics
probiotics

Published Papers (5 papers)

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Research

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13 pages, 1790 KiB

Open AccessArticle

Effects of Low Protein Diet on Production Performance and Intestinal Microbial Composition in Pigs

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Vet. Sci. 2023, 10(11), 655; https://doi.org/10.3390/vetsci10110655 - 14 Nov 2023

Viewed by 450

Abstract

In order to study the effects of a low protein diet on the production performance and intestinal microbiota composition of Hexi pigs, twenty-seven Hexi pigs with an initial body weight of 60.50 ± 2.50 kg were randomly divided into three groups (control group (CG), group 1 (G1), and group 2 (G2)) and participated in a 60-day finishing trial. The CG was fed a normal protein level diet with a protein level of 16.0%, and G1 and G2 were fed a low protein level diet with protein levels of 14.0% and 12.0%, respectively. The results showed that the low protein level diet had no significant effect on the production performance of Hexi pigs, compared with the CG, the slaughter rate of G1 and G2 increased by 2.49% (p > 0.05) and 6.18% (p > 0.05), the shear force decreased by 2.43% (p > 0.05) and 15.57% (p > 0.05), the cooking loss decreased by 24.02% (p < 0.05) and 21.09% (p > 0.05), and the cooking percentage increased by 13.20% (p > 0.05) and 11.59% (p > 0.05). From 45 min to 24 h and 48 h after slaughter, each group of pH decreased by 1.02, 0.66, and 0.42. For muscle flesh color, the lightness (L) increased by 13.31% (p > 0.05) and 18.01% (p > 0.05) in G1 and G2 and the yellowness (b) increased by 7.72% (p > 0.05) and 13.06% (p > 0.05). A low protein level diet can improve the intestinal flora richness and diversity of growing and finishing pigs. In the jejunum, the ACE index (899.95), Simpson index (0.90), and Shannon (4.75) index were higher in G1 than in the other groups, but the Chao1 index (949.92) was higher in G2 than in the remaining two groups. Proteobacteria, Actinobacteria, Euryarchaeota, and Verrucomicrobia were significantly higher in G1 than in the CG. The relative abundances of Lactobacillus, Terrisporobacter, and Megasphaera in G1 was significantly higher than in the CG (p < 0.05). In the cecum, the ACE index (900.93), Chao1 index (879.10), Simpson index (0.94), and Shannon (5.70) index were higher in G1 than in the remaining groups. The Spirochaetes in G2 were significantly higher than in the other groups, but the Verrucomicrobia was significantly lower than in the other groups. The relative abundances of Lactobacillus were higher in G1 and G2 than in the CG (p > 0.05). The relative abundances of unidentified_Clostridiales and Terrisporobacter in G2 were significantly lower than in the CG (p < 0.05). The relative abundance of Turicibacter in G1 was significantly lower than in the CG (p < 0.05). The relative abundances of other bacterial genera in G1 and G2 were increased by 30.81% (p > 0.05) and 17.98% (p > 0.05). Full article

(This article belongs to the Special Issue The Regulatory Mechanism of Nutrient Metabolism on Porcine Intestinal Health)

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10 pages, 271 KiB

Open AccessArticle

Dietary Complex Probiotic Supplementation Changed the Composition of Intestinal Short-Chain Fatty Acids and Improved the Average Daily Gain of Growing Pigs

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Vet. Sci. 2023, 10(2), 79; https://doi.org/10.3390/vetsci10020079 - 21 Jan 2023

Cited by 1 | Viewed by 1172

Abstract

At present, probiotics are being extensively evaluated for their efficacy as an alternative to antibiotics, and their safety in livestock production. In this study, 128 (Duroc, Yorkshire and Landrace) pigs with an average initial body weight of 28.38 ± 0.25 kg were allocated to four dietary treatments in a randomized complete-block design. There were eight pens per treatment, with four pigs per pen (two barrows and two gilts). Dietary treatments included: (1) control diet; (2) control diet + 0.05% complex probiotic; (3) control diet + 0.1% complex probiotic; (4) control diet + 0.2% complex probiotic. During the 28-day experimental period, the feeding of 0.1% complex probiotic in the diet increased body weight and average daily gain (p < 0.05). The addition of complex probiotics decreased total cholesterol and glucose concentrations in the blood (p < 0.01). Acetate concentrations in the blood increased from 0.1% complex probiotic in the diet (p < 0.05), while NH₃ and H₂S emissions in the feces decreased (p < 0.05) from 0.1% or 0.2% complex probiotic in the diet. In conclusion, dietary complex probiotic supplementation changed the composition of intestinal short-chain fatty acids and improved growth performance for growing pigs. Full article

(This article belongs to the Special Issue The Regulatory Mechanism of Nutrient Metabolism on Porcine Intestinal Health)

15 pages, 3540 KiB

Open AccessArticle

Joint Application of Lactobacillus plantarum and Bacillus subtilis Improves Growth Performance, Immune Function and Intestinal Integrity in Weaned Piglets

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Vet. Sci. 2022, 9(12), 668; https://doi.org/10.3390/vetsci9120668 - 30 Nov 2022

Cited by 1 | Viewed by 1416

Abstract

This study was conducted to explore the effects of the joint application of Lactobacillus plantarum and Bacillus subtilis on growth performance, immune function, antioxidant capacity, intestinal integrity, and gut microbiota composition in weaned piglets. The piglets were allocated randomly into 4 dietary groups, which were a control diet (NC), NC + 150 ppm mucilage sulfate (PC), and 3 additional diets containing 1 kg/t (LT), 1.5 kg/t (MT), or 2 kg/t (HT) mixture of Lactobacillus plantarum and Bacillus subtilis, respectively. Results showed that joint application of Lactobacillus plantarum and Bacillus subtilis increased ADFI and ADG of weaned piglets in d 14~28 and d 28~42 (p < 0.05), and decreased serum concentrations of DAO, IL-1β, TNF-α, and IL-2. The LT group increased jejunal and colonic sIgA contents compared with the PC group (p < 0.05). Groups of MT and HT increased colonic mRNA expression of host defense peptides and tight junction proteins compared with the NC and PC groups. The joint application of Lactobacillus plantarum and Bacillus subtilis increased the abundance of colonic Lactobacillus compared with NC and PC groups (p < 0.10). In conclusion, the joint application of Lactobacillus plantarum and Bacillus subtilis as an antibiotics alternative improved growth performance via promoting immune function and intestinal integrity of weaned piglets. Full article

(This article belongs to the Special Issue The Regulatory Mechanism of Nutrient Metabolism on Porcine Intestinal Health)

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12 pages, 4252 KiB

Open AccessArticle

Detection of Colistin Sulfate on Piglet Gastrointestinal Tract Microbiome Alterations

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Vet. Sci. 2022, 9(12), 666; https://doi.org/10.3390/vetsci9120666 - 29 Nov 2022

Cited by 2 | Viewed by 1263

Abstract

The gut microbiome exerts important functions on host health maintenance, whereas excessive antibiotic use may cause gut flora dysfunction resulting in serious disease and dysbiosis. Colistin is a broad-spectrum antibiotic with serious resistance phenomena. However, it is unclear whether colistin alters the gastrointestinal tract microbiome in piglets. In this study, 16s rDNA-based metagenome analyses were used to assess the effects of colistin on the modification of the piglet microbiome in the stomach, duodenum, jejunum, cecum, and feces. Both α- and β-diversity indices showed that colistin modified microbiome composition in these gastrointestinal areas. In addition, colistin influenced microbiome composition at the phylum and genus levels. At the species level, colistin upregulated Mycoplasma hyorhinis, Chlamydia trachomatis, Lactobacillus agilis, Weissella paramesenteroides, and Lactobacillus salivarius abundance, but downregulated Actinobacillus indolicus, Campylobacter fetus, Glaesserella parasuis, Moraxella pluranimalium, Veillonella caviae, Neisseria dentiae, and Prevotella disiens abundance in stomachs. Colistin-fed piglets showed an increased abundance of Lactobacillus mucosae, Megasphaera elsdenii DSM 20460, Fibrobacter intestinalis, and Unidentified rumen bacterium 12-7, but Megamonas funiformis, Uncultured Enterobacteriaceae bacterium, Actinobacillus porcinus, Uncultured Bacteroidales bacterium, and Uncultured Clostridiaceae bacterium abundance was decreased in the cecum. In feces, colistin promoted Mucispirillum schaedleri, Treponema berlinense, Veillonella magna, Veillonella caviae, and Actinobacillus porcinus abundance when compared with controls. Taken together, colistin modified the microbiome composition of gastrointestinal areas in piglets. This study provides new clinical rationalization strategies for colistin on the maintenance of animal gut balance and human public health. Full article

(This article belongs to the Special Issue The Regulatory Mechanism of Nutrient Metabolism on Porcine Intestinal Health)

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Review

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12 pages, 619 KiB

Open AccessReview

A Review Focusing on Microbial Vertical Transmission during Sow Pregnancy

Shengjun Liu

Zixi Zhang

and

Longteng Ma

Vet. Sci. 2023, 10(2), 123; https://doi.org/10.3390/vetsci10020123 - 06 Feb 2023

Cited by 1 | Viewed by 1914

Abstract

Microorganisms are closely related to the body’s physiological activities and growth and development of the body, and participate in many physiological metabolic activities. Analysis of the structure and source of early colonizing bacteria in the intestinal tract of humans and rodents shows that early colonizing bacteria in the intestinal tract of mammals have solid maternal characteristics, and maternal microbes play an essential role in the formation of progeny intestinal flora. The placental microbiome, maternal microbiome and breast milk microbiome are currently hot topics in the field of life science. This paper discusses the vertical transmission and endogenous sources of the mother-to-piglet microbiome through these three pathways, aiming to provide a new research idea for intervention in the intestinal microbiome in young piglets. Full article

(This article belongs to the Special Issue The Regulatory Mechanism of Nutrient Metabolism on Porcine Intestinal Health)

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