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Veterinary Sciences
Special Issues
Comparative Oncology and Veterinary Cancer Surveillance
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Comparative Oncology and Veterinary Cancer Surveillance

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Veterinary Biomedical Sciences".

Deadline for manuscript submissions: 15 July 2024 | Viewed by 16025

Special Issue Editors

Dr. Katia Pinello

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Guest Editor
Population Studies Department, School of Medicine and Biomedical Sciences (ICBAS), University of Porto, 4099-002 Porto, Portugal
Interests: animal oncology; cancer epidemiology; comparative oncology; one health; animal diseases; surveillance
Special Issues, Collections and Topics in MDPI journals
Dr. Renee Laufer Amorim

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Guest Editor
Department of Veterinary Clinic, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, Sao Paulo 01049-010, Brazil
Interests: veterinary pathology; comparative oncology; target therapy
Special Issues, Collections and Topics in MDPI journals
Dr. Carlos Eduardo Fonseca-Alves

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Guest Editor
Department of Veterinary Surgery and Animal Reproduction, São Paulo State University (UNESP), Botucatu, Sao Paulo 01049-010, Brazil
Interests: carcinogensis; in silico analysis; mamamry gland tumors; target therapy
Special Issues, Collections and Topics in MDPI journals
Dr. Chiara Palmieri

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Guest Editor
Faculty of Science, School of Veterinary Science, University of Queensland, Gatton Campus, Gatton 4343, Australia
Interests: cancer; dog; prostate cancer; veterinary oncology
Special Issues, Collections and Topics in MDPI journals
Dr. Maria Lucia Zaidan Dagli

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Guest Editor
Laboratory of Experimental and Comparative Oncology, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Av. Prof Dr. Orlando Marques de Paiva, 87, CEP 05508900 São Paulo, Brazil
Interests: cancer; carcinogenesis; cancer epidemiology; cancer etiology
Special Issues, Collections and Topics in MDPI journals
Dr. Fernando O. Mardones

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Guest Editor
Escuela de Medicina Veterinaria, Facultad de Agronomía e Ingeniería Forestal, Facultad de Ciencias Biológicas y Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 7820244, Chile
Interests: veterinary epidemiology; animal disease surveillance; spatial analysis; One Health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer is one of the most prevalent diseases in dogs and humans, being a leading cause of death in both. Interestingly, dogs and humans share many similarities, such as histological appearance, biological behavior, metastatic sites, and genetic alterations. Moreover, several cancer subtypes in dogs have been used for the evaluation of new drug cytotoxicity and antitumor effects. The advances in cancer genome sequencing of feline and canine tumors have provided valuable information for comparison with human cancers, opening a window of opportunity in comparative oncology.

Veterinary cancer surveillance is an important initiative for developing guidelines for capturing and mapping cancer cases in companion animals for accurate cancer registration and investigation of the geographic distribution of cancer. This information could lead to an improved understanding of the role of environment and cancer development since domestic animals have a shorter life span and share the same environment as humans. In particular, the geographical distribution of cancer may provide insights into the role of environmental determinants that promote disease and the development of new or enhanced cancer surveillance systems.

Comparative oncology covers different aspects of cancer research, providing an opportunity to study cancer in animals as a model for human cancers. This Special Issue is devoted to the “Frontiers in Comparative Oncology and Cancer Epidemiology in Animals” and invites authors to contribute original articles and review papers on recent advances in using spontaneous tumors from animals and translational medicine, including comparative oncology initiatives, which fall under the One Health umbrella.

Dr. Katia Pinello
Dr. Renee Laufer Amorim
Dr. Carlos Eduardo Fonseca-Alves
Dr. Chiara Palmieri
Dr. Maria Lucia Zaidan Dagli
Dr. Fernando O. Mardones
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • animal models
  • cancer genomics
  • spontaneous tumors
  • spatial epidemiology

Published Papers (7 papers)

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Research

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17 pages, 4520 KiB  
Article
Doxorubicin as a Potential Treatment Option in Canine Mammary Tumors
by Madalina Luciana Gherman, Oana Zanoaga, Liviuta Budisan, Lajos Raduly and Ioana Berindan-Neagoe
Vet. Sci. 2023, 10(11), 654; https://doi.org/10.3390/vetsci10110654 - 14 Nov 2023
Viewed by 2293
Abstract
Canine mammary tumors represent one of the leading malignant pathologies in female dogs, displaying the importance of efficient therapeutic findings, besides the golden-standard surgery, able to limit the development of the disease. Studies in human cancers demonstrated that Doxorubicin presents a good effect [...] Read more.
Canine mammary tumors represent one of the leading malignant pathologies in female dogs, displaying the importance of efficient therapeutic findings, besides the golden-standard surgery, able to limit the development of the disease. Studies in human cancers demonstrated that Doxorubicin presents a good effect in different biological processes like apoptosis, autophagy, the cell cycle, cell invasion, and the epithelial-to-mesenchymal transition. This study followed the effects of Doxorubicin on two canine mammary cancer cell lines P114 and CMT-U27. Doxorubicin treatment in both cell lines shows an inhibitory effect in cell proliferation and an alteration in expression of the EMT-related genes. The obtained results provide valuable information for revealing the link between Doxorubicin, phenotypic changes, and proliferation dynamics in canine mammary tumor models. Full article
(This article belongs to the Special Issue Comparative Oncology and Veterinary Cancer Surveillance)
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12 pages, 2257 KiB  
Article
Detection of Age-Related Somatic Alterations in Canine Blood Using Next-Generation Sequencing-Based Liquid Biopsy: An Analysis of over 4800 Dogs
by Kristina M. Kruglyak, Allison L. O’Kell, Todd A. Cohen, Maggie A. Marshall, Carlos A. Ruiz-Perez, Francesco Marass, John A. Tynan, Susan C. Hicks, Katherine M. Lytle, Ashley Phelps-Dunn, Gina Brandstetter, Chelsea D. Warren, Lauren R. DiMarzio, Michelle C. Rosentel, Lilian K. Wong, Lisa M. McLennan, Jill M. Rafalko, Daniel S. Grosu, Jason Chibuk, Ilya Chorny, Angela L. McCleary-Wheeler, Andi Flory and Dana W. Y. Tsuiadd Show full author list remove Hide full author list
Vet. Sci. 2023, 10(7), 455; https://doi.org/10.3390/vetsci10070455 - 11 Jul 2023
Viewed by 2117
Abstract
Age-related somatic genomic alterations in hematopoietic cell lines have been well characterized in humans; however, this phenomenon has not been well studied in other species. Next-generation sequencing-based liquid biopsy testing for cancer detection was recently developed for dogs and has been used to [...] Read more.
Age-related somatic genomic alterations in hematopoietic cell lines have been well characterized in humans; however, this phenomenon has not been well studied in other species. Next-generation sequencing-based liquid biopsy testing for cancer detection was recently developed for dogs and has been used to study the genomic profiles of blood samples from thousands of canine patients since 2021. In this study, 4870 client-owned dogs with and without a diagnosis or suspicion of cancer underwent liquid biopsy testing by this method. Copy number variants detected exclusively in genomic DNA derived from white blood cells (WBC gDNA-specific CNVs) were observed in 126 dogs (2.6%; 95% CI: 2.2–3.1); these copy number variants were absent from matched plasma cell-free DNA, and from tumor tissue in dogs with concurrent cancer. These findings were more common in older dogs and were persistent in WBC gDNA in over 70% of patients, with little to no change in the amplitude of the signal across longitudinal samples. Many of these alterations were observed at recurrent locations in the genome across subjects; the most common finding was a partial loss on CFA25, typically accompanied by a partial gain on the same chromosome. These early findings suggest that age-related somatic alterations may be present at an appreciable frequency in the general canine population. Further research is needed to determine the clinical significance of these findings. Full article
(This article belongs to the Special Issue Comparative Oncology and Veterinary Cancer Surveillance)
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9 pages, 12963 KiB  
Communication
A Novel Breast Cancer Xenograft Model Using the Ostrich Chorioallantoic Membrane—A Proof of Concept
by Marta Pomraenke, Robert Bolney, Thomas Winkens, Olga Perkas, David Pretzel, Bernhard Theis, Julia Greiser and Martin Freesmeyer
Vet. Sci. 2023, 10(5), 349; https://doi.org/10.3390/vetsci10050349 - 12 May 2023
Cited by 4 | Viewed by 2597
Abstract
The avian chorioallantoic membrane (CAM) assay has attracted scientific attention in cancer research as an alternative or complementary method for in vivo animal models. Here, we present a xenograft model based on the ostrich (struthio camelus) CAM assay for the first time. [...] Read more.
The avian chorioallantoic membrane (CAM) assay has attracted scientific attention in cancer research as an alternative or complementary method for in vivo animal models. Here, we present a xenograft model based on the ostrich (struthio camelus) CAM assay for the first time. The engraftment of 2 × 106 breast cancer carcinoma MDA-MB-231 cells successfully lead to tumor formation. Tumor growth monitoring was evaluated in eight fertilized eggs after xenotransplantation. Cancer cells were injected directly onto the CAM surface, close to a well-vascularized area. Histological analysis confirmed the epithelial origin of tumors. The CAM of ostrich embryos provides a large experimental surface for the xenograft, while the comparably long developmental period allows for a long experimental window for tumor growth and treatment. These advantages could make the ostrich CAM assay an attractive alternative to the well-established chick embryo model. Additionally, the large size of ostrich embryos compared to mice and rats could help overcome the limitations of small animal models. The suggested ostrich model is promising for future applications, for example, in radiopharmaceutical research, the size of the embryonal organs may compensate for the loss in image resolution caused by physical limitations in small animal positron emission tomography (PET) imaging. Full article
(This article belongs to the Special Issue Comparative Oncology and Veterinary Cancer Surveillance)
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Review

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16 pages, 1337 KiB  
Review
Potential Promises and Perils of Human Biological Treatments for Immunotherapy in Veterinary Oncology
by Jeilene N. Hambly, Carl E. Ruby, Dan V. Mourich, Shay Bracha and Brian P. Dolan
Vet. Sci. 2023, 10(5), 336; https://doi.org/10.3390/vetsci10050336 - 09 May 2023
Cited by 1 | Viewed by 2248
Abstract
The emergence of immunotherapy for the treatment of human cancers has heralded a new era in oncology, one that is making its way into the veterinary clinic. As the immune system of many animal species commonly seen by veterinarians is similar to humans, [...] Read more.
The emergence of immunotherapy for the treatment of human cancers has heralded a new era in oncology, one that is making its way into the veterinary clinic. As the immune system of many animal species commonly seen by veterinarians is similar to humans, there is great hope for the translation of human therapies into veterinary oncology. The simplest approach for veterinarians would be to adopt existing reagents that have been developed for human medicine, due to the potential of reduced cost and the time it takes to develop a new drug. However, this strategy may not always prove to be effective and safe with regard to certain drug platforms. Here, we review current therapeutic strategies that could exploit human reagents in veterinary medicine and also those therapies which may prove detrimental when human-specific biological molecules are used in veterinary oncology. In keeping with a One Health framework, we also discuss the potential use of single-domain antibodies (sdAbs) derived from camelid species (also known as Nanobodies™) for therapies targeting multiple veterinary animal patients without the need for species-specific reformulation. Such reagents would not only benefit the health of our veterinary species but could also guide human medicine by studying the effects of outbred animals that develop spontaneous tumors, a more relevant model of human diseases compared to traditional laboratory rodent models. Full article
(This article belongs to the Special Issue Comparative Oncology and Veterinary Cancer Surveillance)
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16 pages, 1177 KiB  
Review
Modern Imaging Techniques in the Study and Disease Diagnosis of the Mammary Glands of Animals
by Mariana S. Barbagianni and Pagona G. Gouletsou
Vet. Sci. 2023, 10(2), 83; https://doi.org/10.3390/vetsci10020083 - 22 Jan 2023
Cited by 3 | Viewed by 1931
Abstract
The study of the structure and function of the animals’ mammary glands is of key importance, as it reveals pathological processes at their onset, thus contributing to their immediate treatment. The most frequently studied mammary diseases are mastitis in cows and ewes and [...] Read more.
The study of the structure and function of the animals’ mammary glands is of key importance, as it reveals pathological processes at their onset, thus contributing to their immediate treatment. The most frequently studied mammary diseases are mastitis in cows and ewes and mammary tumours in dogs and cats. Various imaging techniques such as computed tomography, positron emission tomography, magnetic resonance imaging, and ultrasonographic techniques (Doppler, contrast-enchanced, three-dimensional and elastography) are available and can be applied in research or clinical practice in order to evaluate possible abnormalities in mammary glands, as well as to assist in the differential diagnosis. In this review, the above imaging technologies are described, and the perspectives of each method are highlighted. It is inferred that ultrasonographic modalities are the most frequently used imaging techniques for the diagnosis of clinical or subclinical mastitis and treatment guidance on a farm. In companion animals, a combination of imaging techniques should be applied for a more accurate diagnosis of mammary tumours. In any case, the confirmation of the diagnosis is provided by laboratory techniques. Full article
(This article belongs to the Special Issue Comparative Oncology and Veterinary Cancer Surveillance)
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Other

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7 pages, 4086 KiB  
Case Report
Unusual Canine Cutaneous Melanoma Presenting Parietal Bone Metastasis: A Case Report
by Ozana-Maria Hritcu, Florentina Bocaneti Daraban, Fabian Dominic Bacusca and Aurelian-Sorin Pasca
Vet. Sci. 2023, 10(4), 282; https://doi.org/10.3390/vetsci10040282 - 06 Apr 2023
Cited by 1 | Viewed by 1882
Abstract
Melanocytic tumour anatomic location is considered an important prognostic indicator. The cutaneous forms are generally considered benign and may show various biological behaviours. This work reports a rare case of canine cutaneous melanoma showing parietal bone metastasis. Bone invasion in melanocytic tumours is [...] Read more.
Melanocytic tumour anatomic location is considered an important prognostic indicator. The cutaneous forms are generally considered benign and may show various biological behaviours. This work reports a rare case of canine cutaneous melanoma showing parietal bone metastasis. Bone invasion in melanocytic tumours is often described in oral or visceral melanomas, but not in cutaneous forms. The patient (dog, male, mixed breed, 12 years) was initially presented for the surgical removal of a cutaneous tumour located on the skin of the carpal region of the right forelimb. Four months after, the patient returned with enlarged lymph nodes and acute respiratory failure. The patient was euthanized due to a decline in physical condition. The necropsy showed metastases in the affected forelimb, regional lymph node, splanchnic organs, parietal bone and meninges. Histopathological examination of tumour tissue samples revealed a mixture of pigmented and non-pigmented spindle and epithelioid melanocytes, while according to immunohistochemistry, the tumours showed a strong immunopositivity for VEGF and MMP-10, and a moderate positivity for MMP-2 expression. This case shows that cutaneous melanocytic tumours may show an aggressive malignant form with positive immunohistochemical reactions for multiple invasiveness factors. Full article
(This article belongs to the Special Issue Comparative Oncology and Veterinary Cancer Surveillance)
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8 pages, 2210 KiB  
Case Report
An Unusual Case of Collision Testicular Tumor in a Female DSD Dog
by Claudia Rifici, Emanuele D’Anza, Viola Zappone, Sara Albarella, Valeria Grieco, Marco Quartuccio, Santo Cristarella, Cornelia Mannarino, Francesca Ciotola and Giuseppe Mazzullo
Vet. Sci. 2023, 10(4), 251; https://doi.org/10.3390/vetsci10040251 - 27 Mar 2023
Viewed by 1643
Abstract
Collision tumors (CT) consist of two independent neoplasms with distinct neoplastic populations. Disorders of sexual development (DSDs) are characterized by atypical sexual development leading to various abnormalities of the genital tract. Sex reversal (SR) syndromes are a type of DSD characterized by a [...] Read more.
Collision tumors (CT) consist of two independent neoplasms with distinct neoplastic populations. Disorders of sexual development (DSDs) are characterized by atypical sexual development leading to various abnormalities of the genital tract. Sex reversal (SR) syndromes are a type of DSD characterized by a discrepancy between chromosomal sex and gonadal development (testes/ovaries) and the presence or the absence of the SRY gene. A phenotypically female 8-year-old Jack Russell terrier dog was referred due to anomalous vaginal discharge and non-pruritic cutaneous bilateral symmetrical alopecia on the flanks. During abdominal palpation, a voluminous mass was detected in the left quadrant area, later confirmed by ultrasound. The owner decided to proceed with euthanasia and necropsy. In the abdominal cavity, the left gonad was increased in size, the right one and the uterus were decreased, and the vagina and vulva appeared to be thickened. Histologically, both gonads were revealed to be testes: the left one was affected by a double neoplastic component (sustentacular tumor and interstitial cell tumor), whereas the right gonad showed coarctated seminiferous tubules. PCR amplification of the genes SRY and AMELX revealed the absence of the MSY region of the Y chromosome. To the authors’ knowledge, this is the first report describing a case of a testicular collision tumor in a DSD SRY-negative dog. Full article
(This article belongs to the Special Issue Comparative Oncology and Veterinary Cancer Surveillance)
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