Topical Collection "Vaccines against Chronic and Persistent Bacterial Infections"
A topical collection in Vaccines (ISSN 2076-393X).Viewed by 62330
An important group of bacterial pathogens have developed the ability to persist and to establish life-long chronic infections in the human host. The persistence infections are established after an acute infection period in which both the innate and acquired immune systems are activated. These pathogenic bacteria have evolved specific mechanisms that contribute to the establishment of a persistent stage that leads to chronic infection. Because bacteria seems to quickly adapt to their environment and to increase survival by hijacking essential immunoregulatory mechanisms designed to reduce the pathologic process of the disease, the effort to prevent these type of infections by the use of specific vaccines seems to be a daunting task. However, newly discovered pathways used by persistent bacteria to evade the host immune system and survive within the different cells that supposed to destroy them has open up the door to the development of vaccines that can target chronic bacterial infections. Therefore, this collection is intended to highlight recent effort to develop and test promising therapeutic and/or prophylactic vaccine platforms against a diverse group of bacterial pathogens, including but not restricted to: Mycobacterium tuberculosis, Salmonella enterica Typhi, Burkholderia pseudomallei, Pseudomonas aeruginosa, Neisseria gonorrhea and N. meningitides, Borrellia burgdorferi, Brucella species, Chlamydia species and Helicobacter pylori.
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