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Vaccines
Special Issues
Fish Viruses and Vaccination
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Fish Viruses and Vaccination

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Veterinary Vaccines".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 4162

Special Issue Editors

Dr. Sandro Klafack

E-Mail Website
Guest Editor
Department of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald, Germany
Interests: fish viruses; fish vaccines; alloherpesviruses; Cyprinid herpesvirus 3
Dr. Sean J. Monaghan

E-Mail Website
Guest Editor
Institute of Aquaculture, University of Stirling, Stirling, UK
Interests: fish immunology; fish vaccines; fish viruses

Special Issue Information

Dear Colleagues,

With the present situation of global warming and increasing population, the demand for nutritious and healthy food is increasing. Aquaculture might be a key to solve this problem. However, viruses limit or even endanger an effective aquaculture production. Our efforts for better animal health and productivity should include a better understanding of the viruses responsible and ideally protective vaccines.

In this Special Issue, we present new insights into important viruses affecting aquaculture production as well as vaccines to combat these viruses. Moreover, we draw attention to new vaccination strategies.

Dr. Sandro Klafack
Dr. Sean J. Monaghan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fish
  • virus
  • vaccine
  • aquaculture
  • adaptive immune response
  • immunomodulation
  • adjuvant
  • vaccination

Published Papers (2 papers)

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Research

18 pages, 8382 KiB  
Article
Innate Immune Response Assessment in Cyprinus carpio L. upon Experimental Administration with Artemia salina Bio-Encapsulated Aeromonas hydrophila Bacterin
by Akshaya Radhakrishnan, D. S. Prabakaran, Thiyagarajan Ramesh, Ramalingam Sakthivel, Kavikumar Ramasamy, Hyo-Shim Han and Sivakamavalli Jeyachandran
Vaccines 2023, 11(4), 877; https://doi.org/10.3390/vaccines11040877 - 21 Apr 2023
Viewed by 1659
Abstract
The present study aimed to analyze the enhancement of innate immune responses in juvenile-stage common carp (Cyprinus carpio L.), upon the administration of heat-killed Aeromonas hydrophila at a dosage of 1 × 107 CFU ml−1 through bio-encapsulation in the aquatic [...] Read more.
The present study aimed to analyze the enhancement of innate immune responses in juvenile-stage common carp (Cyprinus carpio L.), upon the administration of heat-killed Aeromonas hydrophila at a dosage of 1 × 107 CFU ml−1 through bio-encapsulation in the aquatic crustacean, Artemia salina. This work emphasizes the modulation of innate immune response when administered with the bio-encapsulated heat-killed antigen that acts as an inactivated vaccine against Motile Aeromonas Septicemia disease. Bio-encapsulated oral administration of antigens promotes innate immunity in juvenile-stage fishes. The optimization of effective bio-encapsulation of bacterin in Artemia salina nauplii was carried out and the best optimal conditions were chosen for immunization. The functional immune parameters such as myeloperoxidase, lysozyme, alkaline phosphatase, antiprotease and respiratory burst activity in serum, blood and intestinal tissue samples were analyzed along with blood differential leukocyte count and tissue histopathology studies. Both humoral and cellular immune responses analyzed were substantially induced or enhanced in the treatment groups in comparison with the control group. The results showed a significant variation in the bio-encapsulation group than the control group and also were comparable to the protection conferred with immersion route immunization under similar conditions. Thus, most of the innate non-specific immune responses are inducible, despite being constitutive of the fish immune system, to exhibit a basal level of protection and a road to better vaccination strategy in Cyprinus carpio L. aquaculture worldwide. Full article
(This article belongs to the Special Issue Fish Viruses and Vaccination)
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12 pages, 3479 KiB  
Article
Oral Vaccination of Recombinant Saccharomyces cerevisiae Expressing ORF132 Induces Protective Immunity against Cyprinid Herpesvirus-2
by Licong Wang, Maoxia Yang, Sheng Luo, Guanjun Yang, Xinjiang Lu, Jianfei Lu and Jiong Chen
Vaccines 2023, 11(1), 186; https://doi.org/10.3390/vaccines11010186 - 16 Jan 2023
Cited by 6 | Viewed by 2106
Abstract
Cyprinid herpesvirus 2 (CyHV-2) is the etiological agent of herpesviral hematopoietic necrosis (HVHN) disease, which causes serious economic losses in the crucian carp culture industry. In this study, by displaying ORF132 on the surface of Saccharomyces cerevisiae cells (named EBY100/pYD1-ORF132), we evaluated the [...] Read more.
Cyprinid herpesvirus 2 (CyHV-2) is the etiological agent of herpesviral hematopoietic necrosis (HVHN) disease, which causes serious economic losses in the crucian carp culture industry. In this study, by displaying ORF132 on the surface of Saccharomyces cerevisiae cells (named EBY100/pYD1-ORF132), we evaluated the protective efficacy of oral administration against CyHV-2 infection. Intense innate and adaptive immune responses were evoked in both mucosal and systemic tissues after oral vaccination with EBY100/pYD1-ORF132. Importantly, oral vaccination provided significant protection for crucian carp post CyHV-2 infection, resulting in a relative percent survival (RPS) of 64%. In addition, oral administration suppressed the virus load and relieved histological damage in selected tissues. Our results indicated that surface-displayed ORF132 on S. cerevisiae could be used as potential oral vaccine against CyHV-2 infection. Full article
(This article belongs to the Special Issue Fish Viruses and Vaccination)
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