Special Issue "Current Understanding of Immune Response after COVID-19 Vaccination"
Deadline for manuscript submissions: 31 December 2023 | Viewed by 29773
Interests: DNA damage response and inflammation in viral infections and cancer development; type I interferon regulatory network in antiviral and antitumor defense; interaction between chronic viral infections and host ubiquitin system
Interests: autoimmunity; autoinflammation; immune response to infection and vaccines; immunodeficiency
Special Issues, Collections and Topics in MDPI journals
The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, over the last two years has had devastating effects on global health and economics. It seems that universal vaccination is the best strategy to end this pandemic. Currently, the widely used mRNA and AAV vaccines against SARS-CoV-2 are based on the viral spike (S) protein that is required for its binding, fusion, and cell entry. Similar to the viral infection, the vaccines produce serum antibodies at early stages, and also induce long-lasting memory B- and T-cell responses in the recipients. As such, the vaccine-elicited immune response is impaired in older and immunosuppressed recipients, resulting in lower titers of antibodies and weaker protection. As for individuals, antibody titers peak within 3~5 weeks, and then start to decline, which varies depending on individuals. In addition, other immune responses also play important roles in preventing SARS-CoV-2 infection and limiting COVID-19 illness severity, although the mechanisms of their protection are less understood so far. Therefore, a higher antibody titer does not necessarily mean better protection. Compared to antibodies, immunogenicity is a more complex and better measurement of a vaccine. Understanding the complicated immune mechanisms after vaccination will provide valuable information for optimizing vaccine efficacies.
Dr. Shunbin Ning
Dr. Davide Firinu
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- immune response