Journal Browser

► Journal Browser

Special Issue "Diagnosis and Control of African Swine Fever Virus (ASFV) Infection"

Share This Special Issue

Special Issue Editors

Dr. Marisa Arias
E-Mail Website
Guest Editor

European Union Reference Laboratory for ASF and FAO Reference Centre for ASF, Centro de Investigación en Sanidad Animal CISA-INIA/CSIC, Valdeolmos, 28130 Madrid, Spain
Interests: African swine fever disease and African swine fever virus

Dr. Carmina Gallardo
E-Mail Website
Guest Editor

Special Issue Information

Dear Colleagues,

African swine fever (ASF) is currently the most threatening disease in domestic and wild pigs worldwide, for which no commercial vaccine is available. The presence of ASF on five continents, including large parts of Asia, makes ASF the worst livestock pandemic of this century. The causal agent, African swine fever virus (ASFV), is a large and highly complex virus that affects both domestic and wild pigs, such as European and African wild pigs, making it difficult to eradicate in endemic areas with the coexistence of circulating viruses of different virulence. The purpose of this Special Issue of Vaccines is to update knowledge and research on important aspects of the disease related to virus infection, disease dynamics, diagnostic tools, and control strategies. Particular emphasis will be placed on research focused on new vaccine candidates, including the elucidation of vaccine control strategies.

Dr. Marisa Arias
Dr. Carmina Gallardo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

African swine fever
ASF V transmission
ASFV infection dynamic
ASF diagnosis
ASF pathology
ASF control strategies
ASF alternative samples for diagnosis
ASF DIVA test
ASF vaccines

Published Papers (2 papers)

Download All Papers

Order results

Result details

Show export options Show export options

Select all

Export citation of selected articles as:

Research

Jump to: Other

Open AccessArticle

Involvement of the MGF 110-11L Gene in the African Swine Fever Replication and Virulence

and

Vaccines 2023, 11(4), 846; https://doi.org/10.3390/vaccines11040846 - 14 Apr 2023

Viewed by 526

Abstract

African swine fever (ASF) is a highly lethal hemorrhagic viral disease that causes extensive economic and animal welfare losses in the Eurasian pig (Sus scrofa) population. To date, no effective and safe vaccines have been marketed against ASF. A starting point for vaccine development is using naturally occurring attenuated strains as a vaccine base. Here, we aimed to remove the multigene family (MGF) 110 gene of unknown function from the Lv17/WB/Rie1 genome to improve the usability of the virus as a live-attenuated vaccine, reducing unwanted side effects. The MGF 110-11L gene was deleted using the CRISPR/Cas9 method, and the safety and efficacy of the virus were tested in pigs after isolation. The vaccine candidates administered at high doses showed reduced pathogenicity compared to the parental strain and induced immunity in vaccinated animals, although several mild clinical signs were observed. Although Lv17/WB/Rie1/d110-11L cannot be used as a vaccine in its current form, it was encouraging that the undesirable side effects of Lv17/WB/Rie1 at high doses can be reduced by additional mutations without a significant reduction in its protective capacity. Full article

(This article belongs to the Special Issue Diagnosis and Control of African Swine Fever Virus (ASFV) Infection)

► Show Figures

Figure 1

Other

Jump to: Research

Open AccessOpinion

Summary of the Current Status of African Swine Fever Vaccine Development in China

and

Vaccines 2023, 11(4), 762; https://doi.org/10.3390/vaccines11040762 - 29 Mar 2023

Viewed by 871

Abstract

African swine fever (ASF) is a highly lethal and contagious disease of domestic pigs and wild boars. There is still no credible commercially available vaccine. The only existing one, issued in Vietnam, is actually used in limited quantities in limited areas, for large-scale clinical evaluation. ASF virus is a large complex virus, not inducing full neutralizing antibodies, with multiple genotypes and a lack of comprehensive research on virus infection and immunity. Since it was first reported in China in August 2018, ASF has spread rapidly across the country. To prevent, control, further purify and eradicate ASF, joint scientific and technological research on ASF vaccines has been carried out in China. In the past 4 years (2018–2022), several groups in China have been funded for the research and development of various types of ASF vaccines, achieving marked progress and reaching certain milestones. Here, we have provided a comprehensive and systematic summary of all of the relevant data regarding the current status of the development of ASF vaccines in China to provide a reference for further progress worldwide. At present, the further clinical application of the ASF vaccine still needs a lot of tests and research accumulation. Full article

(This article belongs to the Special Issue Diagnosis and Control of African Swine Fever Virus (ASFV) Infection)

► Show Figures

Journal Menu

Journal Browser

Special Issue "Diagnosis and Control of African Swine Fever Virus (ASFV) Infection"

Share This Special Issue

Special Issue Editors

Special Issue Information

Keywords

Published Papers (2 papers)

Research

Other

Further Information

Guidelines

MDPI Initiatives

Follow MDPI