Special Issue "Multiple Sclerosis and Its Complications: Clinical Trials"
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 19867
Interests: cancer; autoimmunity; mental health; vaccines; exercise; infectious diseases; drugs; healthy aging; bioactives
Special Issues, Collections and Topics in MDPI journals
Special Issue in Cancers: Cancer Vaccines: Research and Applications
Special Issue in Vaccines: Therapeutic Approaches for Type 1 and Type 2 Diabetes
Special Issue in Brain Sciences: Advances in Multiple Sclerosis Research—Series I
Special Issue in Brain Sciences: Advances in Multiple Sclerosis Research—Series II
Special Issue in Vaccines: Vaccines for Infectious and Chronic Diseases
Special Issue in Biologics: Anti-SARS-CoV-2/COVID-19 Drugs and Vaccines
Special Issue in Vaccines: Multiple Sclerosis, Complications and Therapeutics 2.0
Special Issue in Molecules: Advances in Research of Short Peptides II
Special Issue in Biologics: Aged Population and Immunocompromised Patients: Impact on SARS-CoV-2 Variants and Treatment Outcomes
Special Issue in Cancers: Mucins and Cancers
Special Issue in Cancers: Checkpoint Markers and Cancer Microenvironment: What Do We Know?
Special Issue in International Journal of Molecular Sciences: Chronic Diseases: Gut-Brain-Immune-Microbiome Axis
Special Issue in International Journal of Molecular Sciences: Mechanisms and Interventions for Neurological and Psychological Disorders
Special Issue in Vaccines: Vaccines for Infectious and Chronic Diseases 2.0
Special Issue in Biomedicines: Bioactive Compounds in Chronic Diseases
Special Issue in International Journal of Molecular Sciences: Mechanisms and Interventions for Neurological and Psychological Disorders 2.0
Special Issue in Biologics: Anti-SARS-CoV-2/COVID-19 Drugs and Vaccines: Part II
Special Issue in Viruses: SARS-CoV-2: Vaccine Design and Host Immunity
Topics: Inflammation: The Cause of All Diseases
Topics: Recent Advances in Healthy Ageing
Topics: Inflammation: The Cause of all Diseases 2.0
The World Health Organization (WHO) estimates that over 2.5 million people globally suffer from MS. With the present global population growing to an unprecedented height of 6.5 billion in 2005 and anticipated to reach 7.6 billion by 2020, the prevalence and onset of MS in children and particularly adults is expected to rise exponentially. It is estimated that approximately 400,000 people suffer from MS in the US, with 500,000 Europeans and 18,000 Australians also suffering the disease. There are different subtypes of the disease characterised by increasing severity; benign MS, relapse/remitting MS (RRMS), secondary progressive MS (SPMS) and primary progressive MS (PPMS). According to the international Federation of MS Societies, the estimated breakdown of the four types of MS described above is as follows: benign MS (20%), RRMS (25%), SPMS (40%) and PPMS (15%).
The MS market is expected to more than double in value across the major markets from 2006 to reach $10.7 billion in 2019 and is one of the fastest growing CNS therapy areas. One of the drivers behind this growth is the uptake of specific drugs in interferon naïve patients. Despite the market’s growth the MS market is relatively immature with only 5 products specifically indicated for the disease.
The MS specific therapies that are currently on the market include
- Schering AG’s Betaferon/Betaseron (interferon beta-1b)
- Biogen’s Avonex (interferon beta-1a)
- Teva’s Copaxone (glatiramer acetate)
- Serono/Pfizer’s Rebif (interferon beta-1a)
- Amgen/Serono’s Novantrone (mitoxantrone)
The current drugs available are extremely expensive costing up to $17,000 depending on the country. Due to the limited affordable treatment options, there is no effective therapy able to stop progression of disease (beta interferon-1a approved for delaying progression of MS) there is a very high unmet need in the MS market particularly in the following areas:
- Altering / stopping disease progression
- Inducing and maintaining remission
- Improved drug delivery methods
- Cheaper drugs / therapies
For improved MS treatments it is relatively weak as compared to other CNS disorders, although there are a number of different drug classes in development including;
- Monoclonal Antibodies - to block destructive immune cells entering brain and spinal cord
- Immunosuppressant’s - suppress immune system and prevent myelin damage
- Potassium channel blockers - improve the conduction of demyelinated fibers
- Protein growth factors - to limit demyelination and oligodendrocyte injury
- Immunotherapy / Vaccines - to switch immune response to protect neurons and prevent demyelination
This special issue is now open and is seeking research papers and reviews on MS human clinical studies.
Prof. Dr. Vasso Apostolopoulos
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Multiple sclerosis
- Clinical trials
- Altered peptide ligands
- Immune therapies
- Monoclonal Antibodies
- Growth Factors
- Potassium channel blockers
- Side effects
- Delivery systems
- Particulate vaccines
- Natural products