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Vaccines
Special Issues
Impact of Obesity and Metabolic Diseases on Immunity and Vaccination
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Impact of Obesity and Metabolic Diseases on Immunity and Vaccination

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccine Efficacy and Safety".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2637

Special Issue Editor

Dr. Laurent L’homme

E-Mail Website
Guest Editor
Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, University of Lille, F-59000 Lille, France
Interests: nuclear receptors; macrophages; metabolism; free fatty acids; adipose tissue; obesity; liver
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Obesity and metabolic diseases are major health issues with a strong impact on the immune system. Since metabolism and immunity are tightly connected, inappropriate immune responses are commonly seen in metabolic disorders such as obesity increases the risk of severe illness from COVID-19 or type 2 diabetes increases the risk of multiple infections. Moreover, a lower immunization following vaccination is also observed in patients with obesity and several metabolic disorders. The mechanisms underlying these immune alterations remain unclear and extensive work is required to better characterize and understand the impact of obesity and metabolic diseases on the immune system.    

In this Special Issue, we welcome all types of articles (original research and reviews) that address the relationship between obesity or metabolic diseases and immune processes.

Dr. Laurent L’homme
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic diseases
  • COVID
  • diabetes
  • immune
  • obesity

Published Papers (1 paper)

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Review

19 pages, 1280 KiB  
Review
Impact of Obesity and Diabetes in Pregnant Women on Their Immunity and Vaccination
by Magdalena Wierzchowska-Opoka, Arkadiusz Grunwald, Anna K. Rekowska, Aleksandra Łomża, Julia Mekler, Miracle Santiago, Zuzanna Kabała, Żaneta Kimber-Trojnar and Bożena Leszczyńska-Gorzelak
Vaccines 2023, 11(7), 1247; https://doi.org/10.3390/vaccines11071247 - 17 Jul 2023
Viewed by 2034
Abstract
Pregnant women with obesity and diabetes are at increased risk of developing infections and other complications during pregnancy. Several mechanisms are involved in the immunological mechanisms that contribute to reduced immunity in these populations. Both obesity and diabetes are associated with chronic low-grade [...] Read more.
Pregnant women with obesity and diabetes are at increased risk of developing infections and other complications during pregnancy. Several mechanisms are involved in the immunological mechanisms that contribute to reduced immunity in these populations. Both obesity and diabetes are associated with chronic low-grade inflammation that can lead to an overactive immune response. Pregnant women with obesity and diabetes often have an increase in pro-inflammatory cytokines and adipokines, such as TNF-α, IL-6, IL-1β, leptin, and resistin, which are involved in the inflammatory response. Insulin resistance can also affect the functioning of immune cells. Furthermore, both conditions alter the composition of the gut microbiome, which produces a variety of biomolecules, including short-chain fatty acids, lipopolysaccharides, and other metabolites. These substances may contribute to immune dysfunction. In addition to increasing the risk of infections, obesity and diabetes can also affect the efficacy of vaccinations in pregnant women. Pregnant women with obesity and diabetes are at increased risk of developing severe illness and complications from COVID-19, but COVID-19 vaccination may help protect them and their fetuses from infection and its associated risks. Since both obesity and diabetes classify a pregnancy as high risk, it is important to elucidate the impact of these diseases on immunity and vaccination during pregnancy. Research examining the efficacy of the COVID-19 vaccine in a high-risk pregnant population should be of particular value to obstetricians whose patients are hesitant to vaccinate during pregnancy. Further research is needed to better understand these mechanisms and to develop effective interventions to improve immune function in these populations. Full article
(This article belongs to the Special Issue Impact of Obesity and Metabolic Diseases on Immunity and Vaccination)
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