Cholesterol Metabolism as a Regulator of Immunity
Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 733
Interests: HIV accessory genes; HIV-related lipid disregulation; HIV-related mechanisms of inflammation; HIV-infected cells; anti-HIV compounds; HIV-1 translocation
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Cholesterol metabolism has direct or indirect effects on virtually all cellular processes, from cell proliferation to cell-cell communications to cell fate. This widespread influence on cellular functions by a seemingly distinct metabolic branch is due to a unique role that cholesterol metabolism plays in the genesis of the cellular membranes, which are the drivers of most cellular and intercellular physiological functions. It is therefore not surprising that physiological activity of the immune cells is highly dependent on cholesterol metabolism. Some of this regulation is via the influence of the membrane composition on signal transduction within the immune cells. This involves the effect of cholesterol on lipid rafts, where receptors for the inflammatory factors concentrate. Lipid rafts are also the membrane regions where antigen-presenting molecules concentrate, and cholesterol-rich membrane domains are essential for interactions between the immune cells. Cholesterol has been also shown to directly influence signaling processes inside the cell. Intracellular membranes play an important role in cell division, as well as in the transport of incoming and outcoming factors. In this series of articles, we will overview the mechanistic links connecting cholesterol metabolism to the function of immune cells and ultimately to the host immunity against the pathogens.
Prof. Dr. Michael Bukrinsky
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- cholesterol metabolism
- immune cells
- host immunity