Special Issue "State of the Art and Future Directions of Synthetic Biology-Armed Vaccine Development"

A special issue of Vaccines (ISSN 2076-393X).

Deadline for manuscript submissions: 30 November 2023 | Viewed by 1438

Special Issue Editors

School of Life Sciences, East China Normal University, Shanghai 200062, China
Interests: synthetic biology; synthetic cells; origin of life; liposome; protein and vaccine production
Dr. Jae Man Lee
E-Mail Website
Guest Editor
Laboratory of Creative Science for Insect Industries, Kyushu University Graduate School of Bioresource and Bioenvironmental Sciences, Motooka 744, Nishi-ku, Fukuoka 819-0395, Japan
Interests: silkworm-baculovirus expression vector system; protease

Special Issue Information

Dear Colleagues,

Synthetic biology provides novel approaches for rebuilding existing biological systems or redesigning new ones from scratch for various applications. Over time, the so-called “bottom-up” synthetic biology has expanded to many research subjects, including biology, chemistry, computational sciences, and engineering. The state-of-the-art concepts and strategies of synthetic biology can also activate and shape the future of vaccine development into the next generation. Thus, we would like to invite researchers worldwide to contribute to this Special Issue with recent advances in the vaccine/antibody production and mechanism study armed with rational designs from synthetic biology. We welcome high-quality mini-review and research articles with results from various host models aimed at either laboratory or industrial level. Articles on synthetic cell-based antigen display or drug delivery systems are also welcome.

Dr. Jian Xu
Dr. Jae Man Lee
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vaccine development
  • synthetic biology
  • bottom-up approach
  • antigen production
  • synthetic cell
  • drug delivery system

Published Papers (1 paper)

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Review

Review
Anti-HERV-K Drugs and Vaccines, Possible Therapies against Tumors
Vaccines 2023, 11(4), 751; https://doi.org/10.3390/vaccines11040751 - 28 Mar 2023
Cited by 1 | Viewed by 1152
Abstract
The footprint of human endogenous retroviruses (HERV), specifically HERV-K, has been found in malignancies, such as melanoma, teratocarcinoma, osteosarcoma, breast cancer, lymphoma, and ovary and prostate cancers. HERV-K is characterized as the most biologically active HERV due to possession of open reading frames [...] Read more.
The footprint of human endogenous retroviruses (HERV), specifically HERV-K, has been found in malignancies, such as melanoma, teratocarcinoma, osteosarcoma, breast cancer, lymphoma, and ovary and prostate cancers. HERV-K is characterized as the most biologically active HERV due to possession of open reading frames (ORF) for all Gag, Pol, and Env genes, which enables it to be more infective and obstructive towards specific cell lines and other exogenous viruses, respectively. Some factors might contribute to carcinogenicity and at least one of them has been recognized in various tumors, including overexpression/methylation of long interspersed nuclear element 1 (LINE-1), HERV-K Gag, and Env genes themselves plus their transcripts and protein products, and HERV-K reverse transcriptase (RT). Therapies effective for HERV-K-associated tumors mostly target invasive autoimmune responses or growth of tumors through suppression of HERV-K Gag or Env protein and RT. To design new therapeutic options, more studies are needed to better understand whether HERV-K and its products (Gag/Env transcripts and HERV-K proteins/RT) are the initiators of tumor formation or just the disorder’s developers. Accordingly, this review aims to present evidence that highlights the association between HERV-K and tumorigenicity and introduces some of the available or potential therapies against HERV-K-induced tumors. Full article
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