Special Issue "Vaccine against Poultry Diseases"

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Veterinary Vaccines".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 1046

Special Issue Editor

Department of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
Interests: poultry; probiotics; microbiology; vaccinology; antibiotic resistance; medicinal plants

Special Issue Information

Dear Colleagues,

Poultry production is increasing globally to meet the demand of animal-source proteins. Chicken meat and eggs are cheap and readily available animal-source foods. Time and again, poultry production has faced setbacks across the globe due to infectious disease outbreaks at the farm level that not only lead to production and economic losses, but also put food security at risk.

Robust vaccines and stringent vaccination procedures supplemented with farm biosecurity are essential to control infectious diseases. To date, many vaccines are commercially available against major poultry diseases, with promising results that need to be validated by the broader scientific community. We are launching this Special Issue, “Vaccines against poultry diseases”, and welcome papers highlighting recent and modern approaches towards the development of next-generation poultry vaccines. We will also accept papers emphasizing the molecular diagnosis, epidemiology and control of poultry diseases. Manuscripts dealing with the study of barriers to vaccine uptake, the preparedness of farming communities against poultry disease and making technology available to the farming community will be considered only if the subject is relevant to poultry vaccines. The mission is to enhance the scientific knowledge in the field of poultry vaccines and to promote poultry health.

Dr. Muhammad Nawaz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

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Published Papers (1 paper)

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16 pages, 4555 KiB  
Efficacy of Fowlpox Virus Vector Vaccine Expressing VP2 and Chicken Interleukin-18 in the Protection against Infectious Bursal Disease Virus
Vaccines 2023, 11(11), 1716; https://doi.org/10.3390/vaccines11111716 - 14 Nov 2023
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In mammals, the role of interleukin-18 (IL-18) in the immune response is to drive inflammatory and, normally therefore, anti-viral responses. IL-18 also shows promise as a vaccine adjuvant in mammals. Chicken IL-18 (chIL-18) has been cloned. The aim of this study was to [...] Read more.
In mammals, the role of interleukin-18 (IL-18) in the immune response is to drive inflammatory and, normally therefore, anti-viral responses. IL-18 also shows promise as a vaccine adjuvant in mammals. Chicken IL-18 (chIL-18) has been cloned. The aim of this study was to investigate the potential of chIL-18 to act as a vaccine adjuvant in the context of a live recombinant Fowlpox virus vaccine (fpIBD1) against Infectious bursal disease virus (IBDV). fpIBD1 protects against mortality, but not against damage to the bursa of Fabricius caused by IBDV infection. The Fowlpox virus genome itself contains several candidate immunomodulatory genes, including potential IL-18 binding proteins (IL-18bp). We knocked out (Δ) the potential IL-18bp genes in fpIBD1 and inserted (::) the cDNA encoding chIL-18 into fpIBD1 in the non-essential ORF030, generating five new viral constructs –fpIBD1::chIL-18, fpIBD1ΔORF073, fpIBD1ΔORF073::chIL-18, fpIBD1ΔORF214, and fpIBD1ΔORF214::chIL-18. The subsequent protection from challenge with virulent IBDV, as measured by viral load and bursal damage, given by these altered fpIBD1 strains, was compared to that given by the original fpIBD1. Complete protection was provided following challenge with IBDV in chicken groups vaccinated with either fpIBDIΔ073::IL-18 or fpIBD1Δ214::IL-18, as no bursal damage nor IBDV was detected in the bursae of the birds. The results show that chIL-18 can act as an effective vaccine adjuvant by improving the fpIBD1 vaccine and providing complete protection against IBDV challenge. Full article
(This article belongs to the Special Issue Vaccine against Poultry Diseases)
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