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Vaccines
Special Issues
Recent Research on Human Papillomavirus (HPV) Infection and Vaccination
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Recent Research on Human Papillomavirus (HPV) Infection and Vaccination

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Human Papillomavirus Vaccines".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 5247

Special Issue Editors

Dr. Li Shi

E-Mail Website
Guest Editor
Laboratory of Immunogenetics, Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Kunming 650118, China
Interests: major research interests in the immunogenetic basis of susceptibility and resistance to human papilloma virus infection; the application of immunogenetics in novel vaccine design, development and evaluation, such as HPV therapeutic vaccine
Prof. Dr. Yufeng Yao

E-Mail Website
Guest Editor
Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China
Interests: the interaction of host-HPV in the development of cervical cancer and the HPV therapeutic vaccine

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute a paper for the special edition on “Recent Research on Human Papillomavirus (HPV) Infection and Vaccination”. Persistent infection with high-risk Human papillomavirus is associated with virtually all cervical cancers and a significant proportion of anogenital and oropharyngeal cancers. In recent years, significant progress has been made in cervical cancer prevention, especially in terms of the availability of prophylactic vaccines. However, the HPV vaccine has not yet achieved full coverage, and rates have dropped during the COVID-19 pandemic. It is therefore necessary to strengthen HPV vaccine education, vaccination and early prevention, especially in situations such as in low-income countries, where there are still multiple issues related to its dissemination and acceptance. Meanwhile, exploring the various aspects underlying the mechanism of progression of HPV-associated malignancies, host immune system reactions toward HPV viruses as well as HPV vaccination are important for the development of specific therapeutics and vaccines against viral clinical manifestations.

Original research articles and reviews are welcome in this Special Issue. Research areas may include (but are not limited to) discussing the knowledge and attitudes surrounding prophylactic HPV vaccination; vaccination implementation; effective instruments or interventions to improve public awareness of HPV vaccination; improving equity in HPV vaccination; the impact of the COVID-19 pandemic on HPV vaccination; host factors related to HPV infection, persistent, cervical intraepithelial neoplasia, and cervical cancer; co-infection of HPV with other pathogens; progression of HPV-associated malignancies; HPV and host–virus interaction; novel HPV vaccine development.

We look forward to receiving your contributions.

Dr. Li Shi
Prof. Dr. Yufeng Yao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • HPV infection
  • HPV vaccination
  • willingness
  • hesitancy
  • therapeutic vaccines
  • cervical cancer prevention

Published Papers (5 papers)

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Research

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16 pages, 8455 KiB  
Article
Immunoinformatics Design and In Vivo Immunogenicity Evaluation of a Conserved CTL Multi-Epitope Vaccine Targeting HPV16 E5, E6, and E7 Proteins
by Ni Guo, Zhixin Niu, Zhiling Yan, Weipeng Liu, Lei Shi, Chuanyin Li, Yufeng Yao and Li Shi
Vaccines 2024, 12(4), 392; https://doi.org/10.3390/vaccines12040392 - 09 Apr 2024
Viewed by 321
Abstract
Human papillomavirus type 16 (HPV16) infection is responsible for more than 50% of global cervical cancer cases. The development of a vaccine based on cytotoxic T-lymphocyte (CTL) epitopes is a promising strategy for eliminating pre-existing HPV infections and treating patients with cervical cancer. [...] Read more.
Human papillomavirus type 16 (HPV16) infection is responsible for more than 50% of global cervical cancer cases. The development of a vaccine based on cytotoxic T-lymphocyte (CTL) epitopes is a promising strategy for eliminating pre-existing HPV infections and treating patients with cervical cancer. In this study, an immunoinformatics approach was used to predict HLA-I-restricted CTL epitopes in HPV16 E5, E6, and E7 proteins, and a set of conserved CTL epitopes co-restricted by human/murine MHCs was screened and characterized, with the set containing three E5, four E6, and four E7 epitopes. Subsequently, the immunogenicity of the epitope combination was assessed in mice, and the anti-tumor effects of the multi-epitope peptide vaccine E5E6E7pep11 and the recombinant protein vaccine CTB-Epi11E567 were evaluated in the TC-1 mouse tumor model. The results demonstrated that mixed epitope peptides could induce antigen-specific IFN-γ secretion in mice. Prophylactic immunization with E5E6E7pep11 and CTB-Epi11E567 was found to provide 100% protection against tumor growth in mice. Moreover, both types of the multi-epitope vaccine significantly inhibited tumor growth and prolonged mouse survival. In conclusion, in this study, a multi-epitope vaccine targeting HPV16 E5, E6, and E7 proteins was successfully designed and evaluated, demonstrating potential immunogenicity and anti-tumor effects and providing a promising strategy for immunotherapy against HPV-associated tumors. Full article
(This article belongs to the Special Issue Recent Research on Human Papillomavirus (HPV) Infection and Vaccination)
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15 pages, 241 KiB  
Article
“You Don’t Know If It’s the Truth or a Lie”: Exploring Human Papillomavirus (HPV) Vaccine Hesitancy among Communities with Low HPV Vaccine Uptake in Northern California
by Julie H. T. Dang, Alexandra Gori, Lucy Rios, Angelica M. Rolon, Jingwen Zhang and Moon S. Chen, Jr.
Vaccines 2024, 12(4), 372; https://doi.org/10.3390/vaccines12040372 - 01 Apr 2024
Viewed by 778
Abstract
Background: Vaccine hesitancy, delaying or refusing to vaccinate despite the availability of vaccines, impedes the progress of achieving optimal HPV vaccine coverage. Little is known about the sources of human papillomavirus (HPV) vaccine hesitancy among racially/ethnically and geographically diverse communities. The purpose of [...] Read more.
Background: Vaccine hesitancy, delaying or refusing to vaccinate despite the availability of vaccines, impedes the progress of achieving optimal HPV vaccine coverage. Little is known about the sources of human papillomavirus (HPV) vaccine hesitancy among racially/ethnically and geographically diverse communities. The purpose of this paper is to explore HPV vaccine hesitancy among rural, Slavic, and Latino communities that reside in counties with low HPV vaccine uptake rates. Methods: Key informant interviews and focus groups were conducted with rural, Slavic, and Latino communities that reside within counties in California that have low HPV vaccine up to date rates (16–25%). Qualitative data were transcribed verbatim and analyzed using inductive and deductive thematic analysis. Results: A total of seven focus groups and 14 key informant interviews were conducted with 39 individuals from seven California counties. Salient themes that contributed to HPV vaccine hesitancy included the following: social media and the anti-vaccination movement; a strong belief in acquiring immunity naturally; prior vaccine experiences; and vaccine timing concerns. Participants suggested the provision of culturally appropriate, in-language, in-person easy to understand HPV vaccine education to mitigate HPV vaccine hesitancy. Conclusions: Our findings can inform future interventions to increase HPV vaccine uptake among hesitant communities. Full article
(This article belongs to the Special Issue Recent Research on Human Papillomavirus (HPV) Infection and Vaccination)
10 pages, 256 KiB  
Article
Knowledge of HPV and HPV Vaccination among Polish Students from Medical and Non-Medical Universities
by Dominik Pruski, Sonja Millert-Kalińska, Jan Haraj, Sandra Dachowska, Robert Jach, Jakub Żurawski and Marcin Przybylski
Vaccines 2023, 11(12), 1850; https://doi.org/10.3390/vaccines11121850 - 14 Dec 2023
Viewed by 1182
Abstract
Human papillomavirus (HPV) is a common sexually transmitted infection that can cause both benign and malignant lesions. HPV vaccines, preferably administered before the onset of sexual activity, have demonstrated remarkable efficacy in preventing HPV-related cancers. The impact of a healthcare provider’s recommendation on [...] Read more.
Human papillomavirus (HPV) is a common sexually transmitted infection that can cause both benign and malignant lesions. HPV vaccines, preferably administered before the onset of sexual activity, have demonstrated remarkable efficacy in preventing HPV-related cancers. The impact of a healthcare provider’s recommendation on HPV vaccine acceptance is substantial. Therefore, medical students must undergo thorough training in this domain. This study compares fundamental understanding and viewpoints regarding HPV and anti-HPV vaccines among Polish students pursuing medical and non-medical sciences. This study was based on the authors’ questionnaire, and the results were statistically analyzed. The participants in this study were 1025 students (medical sciences students—520 respondents in total; and non-medical sciences students—505 respondents in total). According to the results, medical students’ knowledge about the consequences of HPV infection and vaccination against HPV was significantly greater. To date, numerous publications have investigated the understanding of particular social, gender, parental, etc., groups about vaccination, but the knowledge of students at different universities—medical and other—has not been compared. Social awareness is still insufficient, even in groups of medical students. There is much to be done to educate and encourage preventive behavior in those not receiving primary prevention in early childhood. Full article
(This article belongs to the Special Issue Recent Research on Human Papillomavirus (HPV) Infection and Vaccination)
14 pages, 266 KiB  
Article
Knowledge and Attitudes towards Human Papillomavirus Vaccination (HPV) among Healthcare Providers Involved in the Governmental Free HPV Vaccination Program in Shenzhen, Southern China
by Danhong Song, Peiyi Liu, Dadong Wu, Fanghui Zhao, Yueyun Wang and Yong Zhang
Vaccines 2023, 11(5), 997; https://doi.org/10.3390/vaccines11050997 - 18 May 2023
Cited by 3 | Viewed by 1615
Abstract
No research has been conducted to explore the variables associated with healthcare providers’ (HCPs) knowledge and attitudes toward the human papillomavirus vaccine (HPV) since the vaccine was approved for free use in some Chinese cities. In Shenzhen, southern China, a convenience sample strategy [...] Read more.
No research has been conducted to explore the variables associated with healthcare providers’ (HCPs) knowledge and attitudes toward the human papillomavirus vaccine (HPV) since the vaccine was approved for free use in some Chinese cities. In Shenzhen, southern China, a convenience sample strategy was used to distribute questionnaires to HCPs involved in the government’s HPV vaccination program from Shenzhen. There were 828 questionnaires collected in total, with 770 used in the analysis. The mean HPV and HPV vaccine knowledge score was 12.0 among HCPs involved in the government HPV vaccination program (with a total score of 15). the average scores for HPV and HPV vaccine knowledge varied among different types of medical institutions. District hospitals had the highest mean score of 12.4, while private hospitals ranked fourth with a mean score of 10.9. Multivariate logistic regression results revealed significant disparities in the type of license and after-tax annual income across HCPs (p < 0.05). The future education and training for HCPs should focus on private community health centers (CHCs), HCPs whose license type is other than a doctor, and HCPs with low after-tax annual income. Full article
(This article belongs to the Special Issue Recent Research on Human Papillomavirus (HPV) Infection and Vaccination)

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17 pages, 1210 KiB  
Systematic Review
School Teachers’ Perceptions of Adolescent Human Papillomavirus (HPV) Vaccination: A Systematic Review
by Jihye Choi, Efrat K. Gabay and Paula M. Cuccaro
Vaccines 2024, 12(4), 361; https://doi.org/10.3390/vaccines12040361 - 27 Mar 2024
Viewed by 615
Abstract
School nurses are uniquely positioned to educate students about immunizations, including human papillomavirus (HPV) vaccination, but schools are often without a nurse for different reasons. In lieu of nurses, teachers who closely interact with students and are traditionally well-trusted by parents may be [...] Read more.
School nurses are uniquely positioned to educate students about immunizations, including human papillomavirus (HPV) vaccination, but schools are often without a nurse for different reasons. In lieu of nurses, teachers who closely interact with students and are traditionally well-trusted by parents may be able to communicate about HPV vaccination, alleviating parental vaccine hesitancy. This systematic review explores school teachers’ perspectives on adolescent HPV vaccination and factors influencing their willingness to make vaccine recommendations. We searched three databases with appropriate medical subject headings and keywords to identify relevant studies. We reviewed fifteen studies and provided an extensive summary and a comparison of the results across the studies. Teachers had low to moderate levels of HPV knowledge with low self-efficacy to counsel parents about the HPV vaccine and expressed concerns about the vaccine condoning adolescent sexual activity, vaccine side effects, and parental disapproval. Nonetheless, some teachers showed interest in learning about vaccine effectiveness in preventing HPV-associated cancers and wanted guidance on vaccine communication with parents, viewing schools as adequate venues to promote and deliver HPV vaccines. Schools should consider educating teachers on HPV and HPV vaccination, with a focus on effective vaccine communication practices to increase adolescent HPV vaccine uptake. Full article
(This article belongs to the Special Issue Recent Research on Human Papillomavirus (HPV) Infection and Vaccination)
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