Special Issue "New Strategies for the Reduction of Uremic Toxins"
Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 43129
Interests: biomarkers of CKD; uremic toxins; microbiota; probiotics; proteomics
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The accumulation of organic waste products, i.e., so-called uremic toxins, that are normally cleared by the kidneys characterizes chronic kidney disease (CKD). First of all, along with a number of known and unknown toxic metabolites, urea have the potential to dysregulate cellular functions in kidney and other organs when patients suffer from an illness known as uremia. It is increasingly evident that uremic toxins influence nontraditional risk factors, such as inflammation and endothelial dysfunction, contributing to cardiovascular (CV) damage in CKD. Particularly, protein-bound uremic toxins seem to play an increasing role in the incidence of CV disease in CKD, as well as in blood pressure regulation and hypertension. This is due to the high binding affinity of these metabolites to serum proteins, which makes them not efficently removable via conventional hemodialysis and causes their progressive accumulation in CKD patients, leading to disease progression and resulting in organ damage. Indeed, in the general population, death from CV disease accounts for approximately one in 1000 people per year (6%–13% of all deaths), whereas among CKD patients, it accounts for 59 in 1000 people per year (26% of total mortality). Therefore, strategies aimed at lowering uremic toxins are strongly desirable, in order to reach clinical benefit in terms of slowing the progression of CKD and preventing CV disease.
Dr. Maria Teresa Rocchetti
Manuscript Submission Information
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- uremic toxins
- chronic kidney disease
- cardiovascular risk
- gut microbiota
- indoxyl sulfate
- p-cresyl sulfate
- New Strategies for the Reduction of Uremic Toxins (2022) in Toxins (5 articles)