New Insight into Ricin Toxicity
Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 603
Interests: interaction of translational machinery with toxins; ribosome-inactivating proteins
Interests: plant and bacterial toxins; antibodies; vaccines; pathophysiology; biodefense
Special Issues, Collections and Topics in MDPI journals
Ricin, one of the most potent protein-based toxins in nature, belongs to the Type II group of ribosome-inactivating proteins (RIPs). Ricin is composed of two subunits: RTA and RTB. The binding subunit RTB is a galactose-specific lectin which promotes toxin attachment to the cell and retrograde trafficking from the plasma membrane to the trans-Golgi network. The enzymatic subunit RTA, an RNA N-glycosidase, mediates the depurination of a single adenine residue within the sarcin–ricin loop of eukaryotic ribosomal RNA and activates multiple stress-activated protein kinase networks and programmed cell death pathways. Although it is well documented that the ribosome represents the primary target for ricin, the underlying molecular basis of cytotoxicity and cellular malfunctions that lead to clinical symptoms remain poorly understood. The cytotoxicity of ricin is clearly related to a combination of effects, including ribotoxic stress, intracellular trafficking, ROS production, ER stress, JNK- and p38-dependent cascades, and activation of apoptosis, but their interdependence and relationship with depurination and translation inhibition has yet to be elucidated. The scope of this Special Issue will be centered on broad aspects of ricin toxicity and other RIP proteins, including the biology of ricin/RIPs, molecular action of the toxins, cell signaling in connection to toxicokinetics, pathophysiology, medical treatment, and all consequences of ricin/RIPs intoxication.
Prof. Dr. Marek Tchórzewski
Prof. Dr. Nicholas Mantis
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- ribosome-inactivating protein
- sarcin–ricin loop