Special Issue "Clostridium difficile Toxins"
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 2277
Interests: bacterial toxins; Clostridioides difficile; SARS-CoV-2; host responses
Special Issues, Collections and Topics in MDPI journals
Clostridioides difficile is a Gram-positive bacterium causing enteric disease mostly under clinical conditions involving antibiotic treatment. Disease manifestations are coupled to the actions of secreted proteinaceous toxins exemplified by TcdB, which is a large multidomain toxin that enters host cells and glucosylates small GTPases. Other toxins produced by C. difficile include TcdA, which is another large clostridial toxin homologous to TcdB, and binary toxin (CDT), which lacks TcdB homology and consists of a subunit with ribosyltransferase activity (CDTa) and a separate subunit with pore-forming activity (CDTb). Disease-causing strains of C. difficile vary in their toxin repertoire but usually possess TcdB. Recent work within this field has explored the complex landscape of toxin receptors and has begun to address how variant toxins alter disease trajectory. The aim of this Special Issue is to build on these recent advances in order to better understand the mechanism of action of C. difficile toxins.
Prof. Dr. Jason L. Larabee
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- C. difficile
- C. difficile toxins
- binary toxin