Special Issue "The Chronic Kidney Disease - Mineral Bone Disorder (CKD-MBD)"
Deadline for manuscript submissions: closed (30 June 2019) | Viewed by 28193
For long times the field of CKD-MBD has been dominated by abnormalities in the concentrations of PTH, vitamin D, phosphate, FGF23 and calcium. Direct associations between these factors in isolation have been described, usually pointing to u-shaped associations with clinical endpoints. These observational data form base of current treatment guidelines.
Recently, rapidly expanding insights are changing the landscape of CKD-MBD. Novel insights point to more complex pathological mechanisms that connect classical biomarkers, in particular PTH and phosphate to clinical disease. Phosphate emerges as an integral component of a specific uremic milieu that drives vascular disease, suggesting that targeting phosphate toxicity is more than targeting hyperphosphatemia. In addition, the perspective on both PTH and bone is shifting from isolated factors to complex regulatory systems, which may culminate in different treatment paradigms for the future. In addition to changing views on classical biomarkers, more components appear to contribute to the syndrome of CKD-MBD. Among those are disturbed homeostasis of Magnesium, the role of macrophages in uremia-associated vascular disease, and recently discovered humoral systems like activin-activation in CKD
These exciting new aspects are all covered in this Special Issue of Toxins, entirely dedicated to the moving field of CKD-MBD. This issue is created in close collaboration with the ERA-EDTA working group on CKD-MBD and is Guest-Edited by Professors Mario Cozzolino and Professor Marc Vervloet.
Prof. Dr. Marc G. Vervloet
Prof. Dr. Mario Cozzolino
Manuscript Submission Information
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- Cardiovascular disease
- Bone disease