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Fluorescence Imaging of Disease Biomarkers
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Fluorescence Imaging of Disease Biomarkers

A special issue of Targets (ISSN 2813-3137).

Deadline for manuscript submissions: 31 August 2024 | Viewed by 3948

Special Issue Editors

Prof. Dr. Ping Li

E-Mail Website
Guest Editor
Chemical Imaging in Universities of Shandong, Institutes of Biomedical Sciences, Shandong Normal University, Jinan 250014, China
Interests: bioimaging; molecular diagnosis and therapy; fluorescent organic molecular probes and nanoprobes
Prof. Dr. Xin Zhang

E-Mail Website
Guest Editor
School of Science, School of Life Sciences, Westlake Laboratory, Westlake University, Hangzhou 310030, China
Interests: fluorescence imaging, chemistry of biological aggregates

Special Issue Information

Dear Colleagues,

This Special Issue aims to publish a set of papers that typify the most exceptional, insightful and original research articles or reviews on fluorescence imaging of disease biomarkers. We expect these papers to be widely read and highly influential within the field.

As a powerful approach for detecting molecular events in biological systems, fluorescence imaging has attracted increasing attention, particularly the visualization of key biomarkers associated with diseases. Thus, this field is perfectly matched with targets for bio-detection.

Prof. Dr. Ping Li
Prof. Dr. Xin Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Targets is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fluorescence imaging
  • molecular probes
  • nanoprobes
  • disease biomarkers
  • in vivo imaging

Published Papers (3 papers)

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Research

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12 pages, 8224 KiB  
Article
Unveiling the Role of Concanavalin A in a Rodent Model of Chemical-Induced Hepatocellular Carcinoma: A Promising Guide in Understanding Liver Cancer Development
by Romelia Pop, Dragoș Hodor, Cornel Cătoi, Teodora Mocan, Lucian Mocan and Alexandru-Flaviu Tăbăran
Targets 2024, 2(1), 52-63; https://doi.org/10.3390/targets2010003 - 16 Feb 2024
Viewed by 760
Abstract
Hepatocellular carcinoma is a pressing global health issue, ranking as the third leading cause of cancer-related mortality in humans. Chronic liver diseases, such as hepatitis B and C infections and cirrhosis, are often associated with hepatocellular carcinoma, necessitating ongoing research for improved diagnostic [...] Read more.
Hepatocellular carcinoma is a pressing global health issue, ranking as the third leading cause of cancer-related mortality in humans. Chronic liver diseases, such as hepatitis B and C infections and cirrhosis, are often associated with hepatocellular carcinoma, necessitating ongoing research for improved diagnostic and therapeutic strategies. Animal models, including both spontaneous and chemically induced models like diethylnitrosamine, play a pivotal role in understanding hepatocellular carcinoma mechanisms. Metabolic alterations in tumoral hepatocytes contribute significantly to cancer initiation and progression, impacting energy metabolism and cell survival. Lectins, specifically Concanavalin A, provide valuable insights into altered glycosylation patterns in cancer cells. This study employs lectin histochemistry to assess hepatic alterations in Concanavalin A expression in a murine model of diethylnitrosamine-induced hepatocellular carcinoma. Utilizing confocal laser scanning microscopy, our study unveils notable changes in Concanavalin A subcellular localization and intensity distribution in hepatocellular carcinoma compared with healthy liver tissue. A significant increase in the Concanavalin A labeling within the tumoral cells and a shifting of the expression within the perinuclear space is observed. These findings offer valuable insights into molecular changes in hepatocellular carcinoma, providing potential avenues for diagnostic and therapeutic advancements. Full article
(This article belongs to the Special Issue Fluorescence Imaging of Disease Biomarkers)
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15 pages, 3896 KiB  
Article
The Synthesis of BODIPY-TKI Conjugates and Investigation of Their Ability to Target the Epidermal Growth Factor Receptor
by Simran Dhingra, Prajesh Shrestha, Arpan Chowdhury, Zehua Zhou, Seetharama D. Jois and Maria da Graça H. Vicente
Targets 2023, 1(1), 48-62; https://doi.org/10.3390/targets1010005 - 30 Aug 2023
Viewed by 1070
Abstract
A near-IR BODIPY was covalently conjugated via its isothiocyanate groups to one or two Erlotinib molecules, a known tyrosine kinase inhibitor (TKI), via triethylene glycol spacers, to produce two novel BODIPY-monoTKI and BODIPY-diTKI conjugates. The ability of these conjugates to target the intracellular [...] Read more.
A near-IR BODIPY was covalently conjugated via its isothiocyanate groups to one or two Erlotinib molecules, a known tyrosine kinase inhibitor (TKI), via triethylene glycol spacers, to produce two novel BODIPY-monoTKI and BODIPY-diTKI conjugates. The ability of these conjugates to target the intracellular domain of the epidermal growth factor receptor (EGFR) was investigated using molecular modeling, surface plasma resonance (SPR), EGFR kinase binding assay, time-dependent cellular uptake, and fluorescence microscopy. While both the BODIPY-monoTKI and the BODIPY-diTKI conjugates were shown to bind to the EGFR kinase by SPR and accumulated more efficiently within human HEp2 cells that over-express EGFR than BODIPY alone, only the BODIPY-monoTKI exhibited kinase inhibition activity. This is due to the high hydrophobic character and aggregation behavior of the BODIPY-diTKI in aqueous solutions, as shown by fluorescence quenching. Furthermore, the competition of the two Erlotinibs in the diTKI conjugate for the active site of the kinase, as suggested by computational modeling, might lead to a decrease in binding relative to the monoTKI conjugate. Nevertheless, the efficient cellular uptake and intracellular localization of both conjugates with no observed cytotoxicity suggest that both could be used as near-IR fluorescent markers for cells that over-express EGFR. Full article
(This article belongs to the Special Issue Fluorescence Imaging of Disease Biomarkers)
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Review

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29 pages, 9546 KiB  
Review
Fluorescent Imaging Agents for Brain Diseases
by Feida Che, Xiaoming Zhao, Xin Wang, Ping Li and Bo Tang
Targets 2023, 1(1), 5-33; https://doi.org/10.3390/targets1010003 - 01 Jun 2023
Viewed by 1544
Abstract
The onset of brain diseases has a terrible impact on people’s lives, including brain tumors, Alzheimer’s disease, Parkinson’s disease, depression, and schizophrenia. Thus, the diagnosis and treatment of various brain disorders have been receiving specific attention. The fluorescence imaging technique is useful for [...] Read more.
The onset of brain diseases has a terrible impact on people’s lives, including brain tumors, Alzheimer’s disease, Parkinson’s disease, depression, and schizophrenia. Thus, the diagnosis and treatment of various brain disorders have been receiving specific attention. The fluorescence imaging technique is useful for examining brain diseases because it is intuitive, in situ, and real-time. Therefore, fluorescent imaging has so far been successfully employed to identify molecules associated with brain disease. In this review, the last five years of research advancements in fluorescent imaging agents for the above diseases are summarized, and the creation of pertinent fluorescence probes is described and prospected. Full article
(This article belongs to the Special Issue Fluorescence Imaging of Disease Biomarkers)
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