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Surgeries
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Surgical Oncology
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Surgical Oncology

A special issue of Surgeries (ISSN 2673-4095).

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 1735

Special Issue Editor

Dr. Takehiko Yokobori

E-Mail Website
Guest Editor
Division of Integrated Oncology Research, Gunma University Initiative for Advanced Research (GIAR), 3-39-22 Showamachi, Maebashi 371-8511, Japan
Interests: surgical oncology; cancer biomarker; immunotherapy; molecular target
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The cancer microenvironment is considered to be critically important for tumor development, progression, and therapeutic sensitivity. In particular, the stroma surrounding cancer cells (including immune cells, fibroblasts, and ECM) has been recognized as an important factor in characterizing cancer tissue, and basic and clinical data indicate that it may be a potential new therapeutic target. Therefore, we are pleased to invite authors to submit original papers and review articles that pathologically address cancer-specific biomarkers and cancer/stroma interactions (including immune cells, fibroblasts, and ECM) in the cancer microenvironment using surgically resected samples.

Dr. Takehiko Yokobori
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Surgeries is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer biomarkers
  • stromal cells
  • immune cells
  • extracellular matrix
  • cancer-associated fibroblast
  • molecular targets

Published Papers (1 paper)

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13 pages, 4981 KiB  
Case Report
Misunderstood Gastric Perforation of a Pancreatic Acinar Cell Carcinoma: A Wolf in Sheep’s Clothing
by Manuela Cuoghi, Cinzia Baccaro, Noemi Zorzetti, Adele Fornelli, Francesco Ferrara, Vincenzo Cennamo and Giuseppe Giovanni Navarra
Surgeries 2023, 4(1), 73-85; https://doi.org/10.3390/surgeries4010009 - 14 Feb 2023
Viewed by 1516
Abstract
A 70-year-old man was admitted to the Emergency Department (ED) for marked asthenia and severe anemia. In addition, a high level of lipase was found. During hospitalization, a locally advanced gastric cancer was diagnosed, with endoscopic evidence of a large polyploid formation originating [...] Read more.
A 70-year-old man was admitted to the Emergency Department (ED) for marked asthenia and severe anemia. In addition, a high level of lipase was found. During hospitalization, a locally advanced gastric cancer was diagnosed, with endoscopic evidence of a large polyploid formation originating under the cardias that occupied most of the gastric lumen. A total body CT scan was performed before surgery; the tumor affected the posterior gastric wall, with tenacious infiltration of the pancreatic body. Therefore, we performed a total gastrectomy with esophageal jejunum anastomosis and reconstruction of intestinal continuity according to Roux, distal spleno-pancreatectomy, and cholecystectomy. At histology, a pancreatic acinar cell carcinoma (PACC) with full thickness infiltration of the gastric wall was diagnosed. Acinar cell carcinomas are highly aggressive neoplasms, and surgical resection, when feasible, is the treatment of choice regardless of size, also because the role of neoadjuvant or adjuvant chemo- or radiotherapy remains uncodified. Full article
(This article belongs to the Special Issue Surgical Oncology)
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