Applications of Nanotechnology in Diagnosis and Therapy

A special issue of Surfaces (ISSN 2571-9637).

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1964

Special Issue Editors


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Guest Editor
Center for Injury Biomechanics, Materials and Medicine, Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA
Interests: nanotechnology; drug delivery in cancer; CNS diseases; brain injury and osteoarthritis; image-guided drug delivery; tissue regeneration
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Guest Editor
Computational Biology Special Lab, Department of Biotechnology, Bannari Amman Institute of Technology, Sathyamangalam 638401, India
Interests: nanomedicine; cancer biology; computational biology; pharmacology

Special Issue Information

Dear Colleagues,

This Special Issue provides a comprehensive platform for researchers and professionals engaged in the design, synthesis, characterization, and application of nanomaterials for targeted drug delivery systems. It encompasses a wide range of topics including the development of nanomaterial-based drug carriers such as nanoparticles, liposomes, dendrimers, and micelles, with a focus on their functionalization and surface modification to achieve enhanced stability, solubility, and bioavailability. This issue also explores the utilization of nanotechnology approaches for targeted drug delivery, encompassing active targeting strategies, ligand–receptor interactions, computer-aided drug delivery, and nanomaterials for drug delivery to specific cells, tissues, organs, or disease sites. It covers the investigation of nano–bio interactions, including cellular uptake, intracellular trafficking, and biodistribution of nanocarriers, the release kinetics and mechanisms of drugs from nanomaterial-based systems, as well as the application of nanomaterials in therapeutics, spanning areas such as cancer treatment, central nervous system drug delivery, infectious disease management, and regenerative and personalized medicine. Finally, it explores novel drug delivery approaches enabled by nanomaterials, for instance combination therapies, gene delivery, photothermal therapy, theranostics, and nanoscale imaging agents, while also considering their regulation, commercialization, and safety.

Dr. Venkatesan Perumal
Dr. Shanmuga Sundari I
Guest Editors

Manuscript Submission Information

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Keywords

  • nanomaterials
  • targeted drug delivery design
  • active targeting strategies
  • computer-aided drug delivery
  • nano–bio interactions
  • infectious disease management

Published Papers (1 paper)

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Research

12 pages, 2700 KiB  
Article
The Antibacterial Performance of Implant Coating Made of Vancomycin-Loaded Polymer Material: An In Vitro Study
by Ali Alenezi
Surfaces 2023, 6(3), 304-315; https://doi.org/10.3390/surfaces6030022 - 13 Sep 2023
Cited by 1 | Viewed by 1415
Abstract
Bacterial adhesion and biofilm formation on the surface of titanium implants are the main causes of implant-associated infection. An antibacterial coating on the implant surface can reduce the risk of biofilm formation. The aim of this study was to investigate the bactericidal effects [...] Read more.
Bacterial adhesion and biofilm formation on the surface of titanium implants are the main causes of implant-associated infection. An antibacterial coating on the implant surface can reduce the risk of biofilm formation. The aim of this study was to investigate the bactericidal effects of a van-comycin-loaded polymer coated on an implant surface. For this purpose, poly(N-isopropylacrylamide) (PNIPAAm) was first synthesized as a homopolymer or by co-polymerization with acrylamide (PNIPAAm-AAm) at a 5% weight ratio. Then, thin and uniform polymer coatings were prepared using the spin coating technique. The degree of surface hydro-philicity of the polymer coatings was evaluated by measuring the water contact angle (CA). For the antibacterial tests, the polymer-coated surfaces were loaded with vancomycin. The tests were performed in three conditions: on a glass surface (control), on a PNIPAAm-AAm-coated surface, and on a PNIPAAm-AAm-coated surface loaded with vancomycin. The death rates of the bacteria in contact with the coated surfaces were evaluated at different temperatures with fluorescence microscopy. A scanning electron microscopy (SEM) analysis of cross sections of the polymer coatings revealed a uniform thin film of approximately 200 nm in thickness. The water contact angle analysis performed at different temperatures revealed that the polymer-coated surfaces were more hydrophobic (CAs ranging between 53° and 63°) than the uncoated glass surface (CA ranging between 15° and 35°). The bacterial death rate, measured at 40 °C or while continuously switching the temperature between 37 °C and 40 °C, was higher in the presence of the surface coated with vancomycin-loaded PNIPAAm-AAm than when using the other surfaces (p-value ≤ 0.001). The vancomycin-loaded polymer coating evaluated in this study exhibited effective antibacterial properties when the polymer reached the phase transition temperature. Full article
(This article belongs to the Special Issue Applications of Nanotechnology in Diagnosis and Therapy)
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