Cancer and Stresses 2.0

A special issue of Stresses (ISSN 2673-7140). This special issue belongs to the section "Animal and Human Stresses".

Deadline for manuscript submissions: closed (30 December 2023) | Viewed by 1794

Special Issue Editors

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Guest Editor
Department of Toxicology “Akademik Danilo Soldatović”, University of Belgrade-Faculty of Pharmacy, 11000 Belgrade, Serbia
Interests: toxicology; endocrine disrupting chemicals; mixtures; human health risk assessment; chemical carcinogenesis
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Guest Editor
Department of Pharmacology & Physiology, School of Biomedical Science, Oklahoma State University Center for Health Sciences, Tulsa, OK 74107-1898, USA
Interests: pancreatic cancer; environmental toxicants; mitochondrial toxicity; apoptosis; cellular regulation; tryptophan-kynurenine pathway; indoleamine 2,3-dioxygenase
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the second volume of our previous Special Issue "Cancer and Stresses".

Cancer is a heterogeneous disease that promotes cell growth, disables cell death mechanisms, and evades immune surveillance and therapy. Metabolic stress is a common occurrence in human tumours and is caused by multiple factors. The tumour-mediated metabolic stress response is linked to both apoptosis and autophagy, and understanding these pathways is essential for developing cancer therapies. In this Special Issue of Stresses, our objective is to explore the mechanisms of cellular stresses in cancer prognosis and treatment. Cells can respond to stress in various ways, ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells. Potential topics regarding cancer development include the molecular mechanisms underlying oxidative stress, DNA damage, immune evasion, apoptosis, use of antioxidants as combination therapy, and potential cellular stress biomarkers. Authors are invited to submit original research papers, reviews, and short communications.

Dr. Aleksandra Buha Đorđević
Dr. Pinar Uysal Onganer
Prof. Dr. David R. Wallace
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Stresses is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cancer
  • mitochondria
  • DNA damage
  • apoptosis
  • oxidative stress
  • cellular stress
  • antioxidants
  • autophagy
  • inflammation
  • cytokines
  • chemokines
  • mutagenicity and genotoxicity

Published Papers (1 paper)

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28 pages, 775 KiB  
Systemic Oxidative Stress Parameters in Skin Cancer Patients and Patients with Benign Lesions
by Emmanouil Karampinis, Paraskevi-Maria Nechalioti, Konstantina Eirini Georgopoulou, George Goniotakis, Angeliki Viktoria Roussaki Schulze, Efterpi Zafiriou and Demetrios Kouretas
Stresses 2023, 3(4), 785-812; - 29 Nov 2023
Cited by 2 | Viewed by 1204
Oxidative stress is caused by an imbalance between the production and subsequent accumulation of reactive oxygen species (ROS) in cells and tissues and the capacity of a biological system to eliminate these reactive substances. Systemic oxidative stress biomarkers in plasma, serum, urine, or [...] Read more.
Oxidative stress is caused by an imbalance between the production and subsequent accumulation of reactive oxygen species (ROS) in cells and tissues and the capacity of a biological system to eliminate these reactive substances. Systemic oxidative stress biomarkers in plasma, serum, urine, or red blood cells have been found to be elevated in many diseases, including skin cancer. UV radiation (UVR) induces damage to biomolecules that enter the bloodstream, reinforcing systemic oxidative stress. On the other hand, pre-existing systemic oxidative stress does not supply the skin with the adequate micronutrients and antioxidant resources to ameliorate the skin’s antioxidant defense against UVR. In both scenarios, skin cancer patients are exposed to oxidative conditions. In the case of warts, oxidation is linked to chronic inflammation, while impaired cutaneous antioxidant defense could ineffectively deal with possible oxidative stimuli from viral agents, such as HPV. Therefore, the aim of our study is to evaluate the existing data on systemic oxidative stress in skin diseases such as non-melanoma skin cancer (NMSC), basal-cell carcinoma (BCC), squamous-cell carcinoma (SCC), and melanoma as well as benign lesions such as actinic keratosis (AK), sebaceous keratosis (SK), and warts. Previous studies have demonstrated that patients with NMSC, melanoma, AK, and warts (both genital and non-genital) are subjected to severe oxidative stress, indicated by disturbed antioxidant enzyme levels, accumulated oxidized proteins and lipid products, and, to a lesser extent, lower concentrations of micronutrients. Interestingly, medical history of NMSC or melanoma as well as stage of skin cancer and treatment approach were found to affect systemic oxidative stress parameters. In the case of warts (both genital and non-genital), high oxidative stress levels were also detected, and they were found to be aligned with their recalcitrant character. Full article
(This article belongs to the Special Issue Cancer and Stresses 2.0)
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