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Special Issue "Microfluidics for Biodiagnostics"

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Sensor Materials".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 1446

Special Issue Editors

CENIMAT/I3N, Departamento de Ciência de Materiais, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa and CEMOP/UNINOVA, Campus da Caparica, 2829-516 Caparica, Portugal
Interests: sensors and biosensors; microfluidics and digital microfluidics; E-skin devices; dielectrics and electroactive materials; dielectric spectroscopy

Special Issue Information

Dear Colleagues,

The field of biodiagnostics is a multidisciplinary area of research involving biology, chemistry, physics, and materials. Research can adopt varied setups and configurations, depending on the target analyte, the bioreceptor to be used, the interface sample/transducer concerned, the transduction principle applied, and the test format used for the specific application (clinic diagnostic, bioprocess monitoring, biosafety, environmental surveillance, etc.). The medical field is one of the most attractive application areas for biodiagnostics, as research in this area could provide reusable devices for the rapid and accurate analysis of physiological parameters and the demand for cost-efficient platforms is the key to success and acceptance in a competitive market. On the other hand, microfluidics provides the possibility of performing sophisticated analysis within chips that have been able to be held in the hand, allowing fast sample analysis, high throughput, portability, and reduced reagent use, all of which are associated with a decreased cost per analysis. These devices can also be designed for simultaneous operation, making the system more reliable as several control assays can be performed simultaneously with multiple samples. This makes microfluidics an essential component of modern lab-on-a-chip platforms for point-of-care (POC) and point-of-need (PON) analyses. Typically, the use of microfluidics allows us to transport, mix, separate, heat, and complete reactions in fluids. While microfluidic flows are traditionally constrained inside closed channels with tens of micrometers made of silicon or polymers such as polydimethylsiloxane (PDMS), digital microfluidics (DMF) is a relatively recent technology that allows the individual control of discrete picoliter to microliter droplets in integrated systems. Paper-based bio detectors are also an emerging and new class of devices that feature several advantages, such as abundance in nature, biodegradability, easy fabrication and manipulation of architecture, easy microfluidics induced by capillary forces, versatile chemical functionalization capabilities, high thermal stability, high mechanical strength, and the easy integration of various nanomaterials. These factors mean that these devices are attractive options for cost-efficient and green/sustainable alternative production technologies.

We invite our colleagues to submit original papers based around the idea of microfluidics. Topics can be related to, but are not limited to:

  • Biosensors;
  • Biodetectors;
  • Micromixers;
  • Digital Microfluidic devices (DMF);
  • Droplet generators;
  • Valves;
  • Paper devices;
  • PCR devices;
  • Lab-on-a-chip;
  • Contaminant’s detection;
  • Food, air, and water quality control.

Dr. Hugo Aguas
Dr. Rui Igreja
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Biosensors
  • Biodetectors
  • Paper devices
  • PCR devices
  • Lab-on-a-Chip
  • Microfabrication
  • Digital Microfluidic devices (DMF)
  • Nanomaterials
  • Plasmonic materials
  • Advances functional materials

Published Papers (1 paper)

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Hybrid Digital-Droplet Microfluidic Chip for Applications in Droplet Digital Nucleic Acid Amplification: Design, Fabrication and Characterization
Sensors 2023, 23(10), 4927; - 20 May 2023
Cited by 1 | Viewed by 832
Microfluidic-based platforms have become a hallmark for chemical and biological assays, empowering micro- and nano-reaction vessels. The fusion of microfluidic technologies (digital microfluidics, continuous-flow microfluidics, and droplet microfluidics, just to name a few) presents great potential for overcoming the inherent limitations of each [...] Read more.
Microfluidic-based platforms have become a hallmark for chemical and biological assays, empowering micro- and nano-reaction vessels. The fusion of microfluidic technologies (digital microfluidics, continuous-flow microfluidics, and droplet microfluidics, just to name a few) presents great potential for overcoming the inherent limitations of each approach, while also elevating their respective strengths. This work exploits the combination of digital microfluidics (DMF) and droplet microfluidics (DrMF) on a single substrate, where DMF enables droplet mixing and further acts as a controlled liquid supplier for a high-throughput nano-liter droplet generator. Droplet generation is performed at a flow-focusing region, operating on dual pressure: negative pressure applied to the aqueous phase and positive pressure applied to the oil phase. We evaluate the droplets produced with our hybrid DMF–DrMF devices in terms of droplet volume, speed, and production frequency and further compare them with standalone DrMF devices. Both types of devices enable customizable droplet production (various volumes and circulation speeds), yet hybrid DMF–DrMF devices yield more controlled droplet production while achieving throughputs that are similar to standalone DrMF devices. These hybrid devices enable the production of up to four droplets per second, which reach a maximum circulation speed close to 1540 µm/s and volumes as low as 0.5 nL. Full article
(This article belongs to the Special Issue Microfluidics for Biodiagnostics)
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