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Rapid Screening in the Life Science Based on Photonics and Plasmonics Technology

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Optical Sensors".

Deadline for manuscript submissions: closed (15 February 2024) | Viewed by 3819

Special Issue Editors

Dr. Fulvio Ratto

E-Mail Website
Guest Editor
Istituto di Fisica Applicata “Nello Carrara”, Consiglio Nazionale delle Ricerche (CNR-IFAC), 50019 Florence, Italy
Interests: imaging laser
Dr. Francesca Rossi

E-Mail Website
Guest Editor
Institute of Applied Physics “Nello Carrara”, CNR-IFAC, Via Madonna del Piano 10, 50019 Sesto Fiorentino, Italy
Interests: bioimaging; biophotonics; personalized medicine

Special Issue Information

Dear Colleagues,

Rapid screening is becoming an urgent need in life science. Efficient and cost-effective devices for fast identification of viral or bacterial fingerprints are crucial for the restoration of normal daily activities during and after the pandemic. Besides, monitoring of pharmacological treatments is of utmost importance in long-term healthcare and in preventing infections (such as sepsis or in the treatment of chronic wounds).

Sensing allergens, pathogens and contaminants fulfills a key role in food safety.

Photonics and plasmonics can support the development of integrated platforms enjoying the appropriate accuracy and complying with the design of compact, portable and easy-to-use devices for biosensors and biomarker recognition with fast response.

Dr. Fulvio Ratto
Prof. Dr. Francesca Rossi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomarkers
  • nanoparticles
  • laser
  • photoacoustics
  • Raman
  • biosensors
  • food safety
  • wound healing
  • infection
  • viruses
  • bacteria

Published Papers (3 papers)

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Research

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12 pages, 2705 KiB  
Article
Simple Binding and Dissociation of a Sialoglycoprotein Using Boronic Acid-Modified Functional Interfaces on Microparticles
by Yukichi Horiguchi, Masato Yasuura, Hiroki Ashiba, Zheng Lin Tan and Takashi Fukuda
Sensors 2024, 24(4), 1080; https://doi.org/10.3390/s24041080 - 07 Feb 2024
Viewed by 605
Abstract
An overexpression of sialic acid is an indicator of metastatic cancer, and selective detection of sialic acid shows potential for cancer diagnosis. Boronic acid is a promising candidate for this purpose because of its ability to specifically bind to sialic acid under acidic [...] Read more.
An overexpression of sialic acid is an indicator of metastatic cancer, and selective detection of sialic acid shows potential for cancer diagnosis. Boronic acid is a promising candidate for this purpose because of its ability to specifically bind to sialic acid under acidic conditions. Notably, the binding strength can be easily modulated by adjusting the pH, which allows for a simple dissociation of the bound sialic acid. In this study, we developed 5-boronopicolinic acid (5-BPA)-modified magnetic particles (BMPs) to selectively capture sialic acid biomolecules. We successfully captured fetuin, a well-known sialoglycoprotein, on BMPs at >104 molecules/particle using an acetate buffer (pH 5.0). Facile dissociation then occurred when the system was changed to a pH 7.6 phosphate buffer. This capture-and-release process could be repeated at least five times. Moreover, this system could enrich fetuin by more than 20 times. In summary, BMPs are functional particles for facile purification and concentration through the selective capture of sialic acid proteins and can improve detection sensitivity compared with conventional methods. This technology shows potential for the detection of sialic acid overexpression by biological particles. Full article
(This article belongs to the Special Issue Rapid Screening in the Life Science Based on Photonics and Plasmonics Technology)
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12 pages, 2503 KiB  
Article
Label-Free SERS and MD Analysis of Biomarkers for Rapid Point-of-Care Sensors Detecting Head and Neck Cancer and Infections
by Edoardo Farnesi, Silvia Rinaldi, Chen Liu, Jonas Ballmaier, Orlando Guntinas-Lichius, Michael Schmitt, Dana Cialla-May and Juergen Popp
Sensors 2023, 23(21), 8915; https://doi.org/10.3390/s23218915 - 02 Nov 2023
Viewed by 1471
Abstract
For the progress of point-of-care medicine, where individual health status can be easily and quickly monitored using a handheld sensor, saliva serves as one of the best-suited body fluids thanks to its availability and abundance of physiological indicators. Salivary biomarkers, combined with rapid [...] Read more.
For the progress of point-of-care medicine, where individual health status can be easily and quickly monitored using a handheld sensor, saliva serves as one of the best-suited body fluids thanks to its availability and abundance of physiological indicators. Salivary biomarkers, combined with rapid and highly sensitive detection tools, may pave the way to new real-time health monitoring and personalized preventative therapy branches using saliva as a target matrix. Saliva is increasing in importance in liquid biopsy, a non-invasive approach that helps physicians diagnose and characterize specific diseases in patients. Here, we propose a proof-of-concept study combining the unique specificity in biomolecular recognition provided by surface-enhanced Raman spectroscopy (SERS) in combination with molecular dynamics (MD) simulations, which give leave to explore the biomolecular absorption mechanism on nanoparticle surfaces, in order to verify the traceability of two validated salivary indicators, i.e., interleukin-8 (IL-8) and lysozyme (LYZ), implicated in oropharyngeal squamous cell carcinoma (OSCC) and oral infection. This strategy simultaneously assures the detection and interpretation of protein biomarkers in saliva, ultimately opening a new route for the evolution of fast and accurate point-of-care SERS-based sensors of interest in precision medicine diagnostics. Full article
(This article belongs to the Special Issue Rapid Screening in the Life Science Based on Photonics and Plasmonics Technology)
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Review

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20 pages, 7672 KiB  
Review
Food Safety Issues in the Oltrepò Pavese Area: A SERS Sensing Perspective
by Benedetta Albini, Pietro Galinetto, Serena Schiavi and Enrico Giulotto
Sensors 2023, 23(22), 9015; https://doi.org/10.3390/s23229015 - 07 Nov 2023
Cited by 1 | Viewed by 957
Abstract
Handly and easy-to-use optical instrumentation is very important for food safety monitoring, as it provides the possibility to assess law and health compliances at every stage of the food chain. In particular, the Surface-enhanced Raman Scattering (SERS) method appears highly promising because the [...] Read more.
Handly and easy-to-use optical instrumentation is very important for food safety monitoring, as it provides the possibility to assess law and health compliances at every stage of the food chain. In particular, the Surface-enhanced Raman Scattering (SERS) method appears highly promising because the intrinsic drawback of Raman spectroscopy, i.e., the natural weakness of the effect and, in turn, of the signal, is overcome thanks to the peculiar interaction between laser light and plasmonic excitations at the SERS substrate. This fact paved the way for the widespread use of SERS sensing not only for food safety but also for biomedicine, pharmaceutical process analysis, forensic science, cultural heritage and more. However, the current technological maturity of the SERS technique does not find a counterpart in the recognition of SERS as a routine method in compliance protocols. This is mainly due to the very scattered landscape of SERS substrates designed and tailored specifically for the targeted analyte. In fact, a very large variety of SERS substrates were proposed for molecular sensing in different environments and matrices. This review presents the advantages and perspectives of SERS sensing in food safety. The focus of the survey is limited to specific analytes of interest for producers, consumers and stakeholders in Oltrepò Pavese, a definite regional area that is located within the district of Pavia in the northern part of Italy. Our attention has been addressed to (i) glyphosate in rice fields, (ii) histamine in a world-famous local product (wine), (iii) tetracycline, an antibiotic often detected in waste sludges that can be dangerous, for instance in maize crops and (iv) Sudan dyes—used as adulterants—in the production of saffron and other spices, which represent niche crops for Oltrepò. The review aims to highlight the SERS performance for each analyte, with a discussion of the different methods used to prepare SERS substrates and the different reported limits of detection. Full article
(This article belongs to the Special Issue Rapid Screening in the Life Science Based on Photonics and Plasmonics Technology)
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