Natural Extracts and Bioactive Derivatives: Strategies for Biopharmaceutical Uses

A special issue of Sci (ISSN 2413-4155). This special issue belongs to the section "Biology Research and Life Sciences".

Deadline for manuscript submissions: closed (20 January 2023) | Viewed by 4516

Special Issue Editors


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Guest Editor
Institute of Neurophysiopathology (INP), Aix-Marseille University, Faculté des sciences médicales et paramédicales, 27, Bd Jean Moulin, 13005 Marseille, France
Interests: antimicrobial peptides; antibacterial; antibiotics; structure-activity relationships; bacteriocins; drug design; peptide engineering
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Guest Editor
Faculty of Sciences 3, Lebanese University, Michel Slayman Tripoli Campus, Ras Maska 1352, Lebanon
Interests: drug design; animal venom enzymes; biomolecules; venoms and toxins; biopharmaceuticals

Special Issue Information

Dear colleagues,

For millennia, natural extracts have been known to treat human diseases and are an important source of medicines. To this day, many people around the world still use traditional drugs extracted from plants or animal secretions. Plant essences largely dominate those of animals in this area. Indeed, many drugs are derived from plants and are currently marketed. As for animal extracts, they are also gradually positioning in the pharmaceutical market. Animal venoms and their bioactive molecules are the subject of intense scientific research, and many patents in the field have been awarded. The therapeutic value of animal venoms depends on their use at appropriate doses or encapsulation/formulation in suitable vesicles in order to enable them to enter into the target cells or to minimize their cytotoxicity, if any. The potential synergistic effects of molecules derived from natural extracts have been widely demonstrated. Such synergy between compounds deserves to be examined in more depth by researchers in the coming years.

This Special Issue titled “Natural Extracts and Bioactive Derivatives: Strategies for Biopharmaceutical Uses” consists of a collection of original research and review articles concerning new advances in (i) the discovery, development and application of natural extracts in biopharmaceuticals; (ii) the potential of molecules derived from natural extracts in various fields of research; (iii) the synergy between such natural compounds for greater beneficial effects; and (iv) strategies for rectifying the activity of the biomolecules. The topics of interest for articles include the activities of crude extracts, the bio-guidance of a valued fractionation and the characterization of new value-added biomolecules. The targeted biological properties include antioxidant, antimicrobial, anticancer, and other effects.

Dr. Jean-Marc Sabatier
Prof. Ziad Fajloun
Guest Editors

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Keywords

  • Bioactive molecules
  • Venom derivatives
  • Plant extracts
  • Anticancer
  • Antimicrobial
  • Toxins
  • Enzymes extracted
  • Natural medicines

Published Papers (1 paper)

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Research

11 pages, 1152 KiB  
Article
Montivipera bornmuelleri Venom: Inhibitory Effect on Staphylococcus epidermidis and Escherichia coli F1F0-ATPases and Cytotoxicity on HCT116 Cancer Cell Lines
by Milena Kfoury, Charbel Mouawad, Mariam Rifi, Riyad Sadek, Jean-Marc Sabatier, Hala Nehme and Ziad Fajloun
Sci 2021, 3(3), 31; https://doi.org/10.3390/sci3030031 - 14 Jul 2021
Cited by 1 | Viewed by 3567
Abstract
In this work, we pursued the biological characterization of the venom of Montivipera bornmuelleri, a viper from the Lebanese mountains. In relation to its antibacterial potential, the inhibitory effect of this venom on the F1F0-ATPase enzymes of Gram-positive [...] Read more.
In this work, we pursued the biological characterization of the venom of Montivipera bornmuelleri, a viper from the Lebanese mountains. In relation to its antibacterial potential, the inhibitory effect of this venom on the F1F0-ATPase enzymes of Gram-positive Staphylocoocus epidermidis and Gram-negative Escherichia coli bacteria was examined. In order to determine the degree of cytotoxicity of the venom on the HCT116 human colon cancer cell lines, the biological MTT proliferation and cell viability test were implemented. After validation of the enzymatic F1F0-ATPase model by the spectrophotometric method, using quercetin as the reference ligand, results revealed that M. bornmuelleri venom is able to inhibit the activity of the enzyme of these two bacteria with a concentration of the order of 100–150 µg/mL. In addition, a venom concentration of 10 µg/mL was sufficient to kill the totality of HCT116 cell lines cultivated in vitro. These data show that M. bornmuelleri venom is a mixture of diverse molecules presenting activities of interest, and is a potential source to explore in order to discover new drug candidates. Full article
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