Dear Colleagues,

Biological testing of medicines and environmental toxins traditionally begins with cell culture and continues with animal experiments, usually in small laboratory rodents. Animal studies, compared to conventional cell culture, have the advantage of more realistic exposure conditions and the ability to evaluate effects on more cell types and on their interaction. Animal experiments are considered the gold standard for biological testing.

Better knowledge of inter-species differences in physiology, particularly regarding the immune system; directives issued by authorities like the European Union to replace animal experimentation; and the development of more physiologically relevant cell culture models will change the currently used tiered testing strategies. It is expected that the role of in silico techniques and cellular models will increase in comparison to animal experiments.

This Special Issue invites submissions on the topic of cellular testing, including but not limited to the comparison between different in vitro models, correlation of in vitro and in vivo models, analytical tools for evaluation of cellular processes, and development of advanced (e.g. dynamic, 3D models, co-culture) in vitro models.

Prof. Eleonore Fröhlich
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sci is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• 3D culture systems
• High throughput screening
• In vitro cell differentiation
• Long-term culture
• Bioreactors
• Co-culture systems
• Organs on a chip
• Tools for standardization
• High content analysis