COVID-19 and Advances in Reproductive Toxicology Assessment

A special issue of Reproductive Medicine (ISSN 2673-3897).

Deadline for manuscript submissions: closed (20 December 2022) | Viewed by 2907

Special Issue Editors


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Guest Editor
Department of Biology, University of Naples Federico II, Naples, Italy
Interests: antioxidative physiological defence; steroids and steroid receptors; antioxidants under steroid control; reproductive health assessment; reprotoxicity monitoring; endangered species and validation of non-destructive examination methods; biodiversity conservation microassays
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Guest Editor
Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, India
Interests: free radicals; antioxidants; cell death mechanisms; genotoxicity; ubiquitin pathway; phytochemicals; epigenetics; and non-coding RNA in reproductive, cancer biology and developing biomarkers and new modalities for treatment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is a great pleasure to invite all researchers within the field of human and comparative reprotoxicology to submit their work for publication in the Special Issue entitled: “COVID-19 and Advances in Reproductive Toxicology Assessment”.

As is commonly known, the exposure of an individual to different chemicals can result in serious consequences to the health of the individual in question. The derived toxicity of free radical overexpression, and the genotoxic effects in somatic and germinal cells can lead to the development of several genetic disorders and infertility. Many recent studies have demonstrated that drug treatments and plastics exert significant endocrine-disrupting effects on organisms, interfering with the normal physiological functions of the reproductive and nervous systems via related signaling pathways. Furthermore, the strategy used worldwide to combat the COVID-19 pandemic involves both behavioral—using disposable face masks—and pharmacological interventions. Therefore, the need for a better understanding of the molecular mechanisms related with oxidative stress, genotoxicity, DNA methylation and their regulation in reprotoxicity is significant. This will help us to understand the potential damage and how to develop potential therapeutic and preventive approaches that will be useful in protecting resources and life sustainability.

We are looking for advanced experimental and computational studies in the form of original articles, review articles and short communications to be included in this Special Issue. Fields of interest for this publication include—but are not limited to— quantitative metagenomics profiling, multi-omics approaches, identification of new potential nutraceuticals to fight COVID-19 reprotoxicity. We encourage researchers working on topics related to these to consider submitting their work for publication.

Prof. Dr. Giulia Guerriero
Dr. Kamla Kant Shukla
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Reproductive Medicine is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Reproduction
  • Reprotoxicity
  • Oxidants and Antioxidative Physiological Defense
  • Steroids and Steroid Receptors
  • Molecular Endocrinology
  • Genotoxicity
  • Epigenetics
  • Fertility
  • Immune and Growth Response
  • Biomarkers

Published Papers (1 paper)

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Review

17 pages, 1967 KiB  
Review
Human Maternal-Fetal Interface Cellular Models to Assess Antiviral Drug Toxicity during Pregnancy
by Savannah L. Herbek, Marie C. Smithgall, Elisabeth A. Murphy, Robert E. Schwartz, Shuibing Chen, Laura E. Riley, Heidi Stuhlmann, Yawei J. Yang and Ria Goswami
Reprod. Med. 2022, 3(4), 303-319; https://doi.org/10.3390/reprodmed3040024 - 01 Dec 2022
Viewed by 2222
Abstract
Pregnancy is a period of elevated risk for viral disease severity, resulting in serious health consequences for both the mother and the fetus; yet antiviral drugs lack comprehensive safety and efficacy data for use among pregnant women. In fact, pregnant women are systematically [...] Read more.
Pregnancy is a period of elevated risk for viral disease severity, resulting in serious health consequences for both the mother and the fetus; yet antiviral drugs lack comprehensive safety and efficacy data for use among pregnant women. In fact, pregnant women are systematically excluded from therapeutic clinical trials to prevent potential fetal harm. Current FDA-recommended reproductive toxicity assessments are studied using small animals which often do not accurately predict the human toxicological profiles of drug candidates. Here, we review the potential of human maternal-fetal interface cellular models in reproductive toxicity assessment of antiviral drugs. We specifically focus on the 2- and 3-dimensional maternal placental models of different gestational stages and those of fetal embryogenesis and organ development. Screening of drug candidates in physiologically relevant human maternal-fetal cellular models will be beneficial to prioritize selection of safe antiviral therapeutics for clinical trials in pregnant women. Full article
(This article belongs to the Special Issue COVID-19 and Advances in Reproductive Toxicology Assessment)
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