Special Issue "Recent Advances in Microfluidic Devices"

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Manufacturing Processes and Systems".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 5290

Special Issue Editors

Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias s/n, 4200-465 Porto, Portugal
Interests: lab-on-a-chip devices; biomimetic particles; droplet microfluidics; blood analogues; CFD
Special Issues, Collections and Topics in MDPI journals
Microfabrication and Exploratory Nanotechnology, Micro and Nanofabrication Department, International Iberian Nanotechnology Laboratory, Braga, Portugal
Interests: microfluidics; nanotechnology; micro- and nano-fabrication; biofluids
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microfluidic systems have many advantages over macroscale devices. Firstly, they offer the ability to work with small sample volume since most of the reagents used in these devices are extremely expensive. These devices not only provide remarkable manipulation and control of samples but also offer the ability to shorten reactions times and the possibility to perform parallel operations. By integrating several steps into a single system, microfluidic devices allow performing rapid measurements in a single step and, consequently, offer great potential in the development of portable and point-of-care devices. Another important advantage is their high surface area to volume ratio, and as a result, they offer high heat transfer rates, suitable for developing efficient micro-heat exchangers. However, the greatest potential of microfluidics is to exploit the advantages of the microscale physics. By understanding and manipulating microscale phenomena, microfluidic devices are systems that enable novel and unique applications that are not possible with conventional macroscale equipment.

For this Special Issue “Recent Advances in Microfluidic Devices”, we invite researchers to submit original and review articles on the latest advances and challenges in the development and applications of microfluidic devices. Topics include, but are not limited to:

  • Micro-/nanofluidic systems
  • Applied microsystems
  • Lab-on-a-chip technology
  • Microfluidic control
  • Micropump of microfluidics
  • Fluidic resistance
  • Microfluidic biochips
  • Point of care diagnostics
  • Biomedical microdevices
  • Organ-on-chips
  • Biomicrofluidics
  • Blood flow
  • Blood analogs
  • Chemistry and biology on a chip
  • Microreactors
  • Visualization techniques for microfluidics
  • Acoustic streaming
  • Heat sinks
  • Heat and mass transport of nanofluids
  • Fabrication of microfluidic devices
  • Numerical simulation of flow, mass, and heat transport in microdevices
  • Mass transport enhancement by microbubbles and microdroplets
  • Effect of surfactants in droplet microfluidics
  • Biorheology
  • Biosensors, optics, and detection
  • Image analysis for microfluidics
  • Cellular and molecular imaging
  • Cell adhesion in microchannels
  • Cell and particle transport in microfluidics

Dr. Rui A. Lima
Dr. João Mário Miranda
Dr. Patrícia Sousa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microfluidics
  • biomicrofluidics
  • mass transport
  • heat transport
  • nanofluids
  • computational fluid dynamics
  • lab-on-a-chip
  • organ-on-chips
  • cell mechanics
  • microreactors
  • droplet microfluidics
  • micro- and nanofabrication
  • lithography
  • soft lithography

Published Papers (3 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Article
Experimental Characterization of a Microfluidic Device Based on Passive Crossflow Filters for Blood Fractionation
Processes 2022, 10(12), 2698; https://doi.org/10.3390/pr10122698 - 14 Dec 2022
Viewed by 1515
Abstract
The separation of red blood cells (RBCs) from blood plasma and the analysis of individual RBCs are of great importance, as they provide valuable information regarding the health of their donor. Recent developments in microfluidics and microfabrication have contributed to the fabrication of [...] Read more.
The separation of red blood cells (RBCs) from blood plasma and the analysis of individual RBCs are of great importance, as they provide valuable information regarding the health of their donor. Recent developments in microfluidics and microfabrication have contributed to the fabrication of microsystems with complex features to promote the separation and analysis of RBCs. In this work, the separation capacity of a multi-step crossflow microfluidic device was evaluated by using a blood analogue fluid made by Brij L4 micelles and human RBCs separated from whole blood, suspended in a solution with hematocrits (Ht) of 0.5 and 1%. All the samples collected at the outlets of the device were experimentally analyzed and compared. The absorbance spectrum was also measured for the prepared blood samples. The results indicate that the tested blood analogue fluid has exhibited a flow behavior similar to that of blood. In addition, the optical absorbance spectrophotometry revealed that it was possible to evaluate the separation efficiency of the microfluidic device, concluding that the concentration of cells was lower at the most lateral outside outlets of the microchannel due to the cumulative effect of the multiple cross-flow filters. Full article
(This article belongs to the Special Issue Recent Advances in Microfluidic Devices)
Show Figures

Graphical abstract

Article
Decrease in Ca2+ Concentration in Quail Cardiomyocytes Is Faster than That in Rat Cardiomyocytes
Processes 2022, 10(3), 508; https://doi.org/10.3390/pr10030508 - 03 Mar 2022
Cited by 1 | Viewed by 1542
Abstract
Mammals and birds have quicker heart rates compared to other species. Mammalian cardiomyocytes have T-tubule membranes that facilitate rapid changes in Ca2+ concentrations. In contrast, bird cardiomyocytes do not possess T-tubule membranes, which raises the question of how birds achieve fast heartbeats. [...] Read more.
Mammals and birds have quicker heart rates compared to other species. Mammalian cardiomyocytes have T-tubule membranes that facilitate rapid changes in Ca2+ concentrations. In contrast, bird cardiomyocytes do not possess T-tubule membranes, which raises the question of how birds achieve fast heartbeats. In this study, we compared the changes in Ca2+ concentration in cardiomyocytes isolated from adult quails and rats to elucidate the mechanism resulting in rapid heart rates in birds. Cardiomyocytes isolated from quails were significantly narrower than those isolated from rats. When Ca2+ concentration changes in the entire cardiomyocytes were measured using Fura-2 acetoxymethyl ester (AM), the time to peak was statistically longer in quails than in rats. In contrast, the decay time was markedly shorter in quails than in rats. As a result, the total time of Ca2+ concentration change was shorter in quails than in rats. A spatiotemporal analysis of Ca2+ concentration changes in quail cardiomyocytes showed that the decrease in Ca2+ concentration was faster in the center of the cell than near the cell membrane. These results suggest that avian cardiomyocytes achieve rapid changes in Ca2+ concentration by increasing the Ca2+ removal capacity in the central part of the cell compared to mammalian cardiomyocytes. Full article
(This article belongs to the Special Issue Recent Advances in Microfluidic Devices)
Show Figures

Figure 1

Article
The Oxygen Gradient in Hypoxic Conditions Enhances and Guides Dictyostelium discoideum Migration
Processes 2022, 10(2), 318; https://doi.org/10.3390/pr10020318 - 07 Feb 2022
Cited by 2 | Viewed by 1306
Abstract
Spatiotemporal variations of oxygen concentration affect the cell behaviors that are involved in physiological and pathological events. In our previous study with Dictyostelium discoideum (Dd) as a model of cell motility, aggregations of Dd cells exhibited long-lasting and highly stable migration [...] Read more.
Spatiotemporal variations of oxygen concentration affect the cell behaviors that are involved in physiological and pathological events. In our previous study with Dictyostelium discoideum (Dd) as a model of cell motility, aggregations of Dd cells exhibited long-lasting and highly stable migration in a self-generated hypoxic environment, forming a ring shape that spread toward the outer higher oxygen region. However, it is still unclear what kinds of changes in the migratory properties are responsible for the observed phenomena. Here, we investigated the migration of Dd to clarify the oxygen-dependent characteristics of aerokinesis and aerotaxis. Migratory behaviors of Dd cells were analyzed under various oxygen concentration gradients and uniform oxygen conditions generated in microfluidic devices. Under hypoxic conditions below 2% O2, corresponding to less than 25 µM O2 in the culture medium, the migration of Dd cells was enhanced (aerokinesis) and the oxygen gradient guided the cells toward the oxygen-rich region (aerotaxis). The aerotaxis was attributed to the increase in the frequency of migration associated with the direction of higher O2, the acceleration of migration velocity, and the enhancement of migration straightness. Thus, aerokinesis and aerotaxis are dependent on both the oxygen level and possibly relative gradient and are essential mechanisms for the migration of Dd. Full article
(This article belongs to the Special Issue Recent Advances in Microfluidic Devices)
Show Figures

Figure 1

Back to TopTop