Special Issue "Recent Advances of Polymer Sciences in 3D Bioprinting and Bioink Formulation"

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (30 July 2023) | Viewed by 1975

Special Issue Editors

Postdoctoral Research Fellow, Institute for Biomechanics, Department of Health Sciences and Technology (D-HEST), ETH Zürich, Zürich, Switzerland
Interests: bioprinting; biomaterials; additive manufacturing; tissue engineering; bio-ink
Allogeneic Stem Cell Manufacturing (ASTEM) Stem Cell Bioprocessing, Bioprocessing Technology Institute, Singapore, Singapore
Interests: cell therapy; mesenchymal stem cells; tissue engineering; stem cells; 3D culture; cultured meat; 3D bioprinting; organoids; vascular biology; skin bioprinting; epithelial biology
Principal Engineer, NUS Centre for Additive Manufacturing (AM.NUS), National University of Singapore, Singapore
Interests: 3D printing; tissue engineering; biomaterials

Special Issue Information

Dear Colleagues,

Bioprinting is a core technology in the field of biofabrication that allows the automated positioning of cells, biomaterials, and biological factors for the production of complex and functional 3D constructs for several biomedical applications. Three-dimensional bioprinting refers to printing living cells and biomaterials and has enabled the highly controlled assembly of cell-laden hydrogels as well as cell suspensions and spheroids as “bioinks”. Bioprinting is an emerging biomanufacturing approach to fabricate functional tissues and organs. There is a growing demand to develop novel printable biomaterials and bioinks to achieve desired properties such as printability and end-use properties (biomechanics, degradation, bioactivity, etc.). Varied kinds of artificial and synthetic polymers are studied to develop bioink formulations for additive manufacturing of medical and food products.

In this Special Issue, we aim to capture the state of the art through research and review papers focusing on all aspects of polymers used in 3D bioprinting technology. Topics covered will include the development of novel (bio)printing technologies, open-source (bio)printers, design and utilization of printable biomaterials, bioinks, development of imaging technologies and software for (bio)printing, 3D printing in medicine and food formulation, and regulatory issues and potential solutions.

Dr. Chris Steffi
Dr. Harish Kiran Handral
Dr. Yanli Cai
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • bioprinting
  • bioink
  • printable biomaterials
  • organoids
  • implants
  • 3D-printed drugs
  • tissue engineering
  • 3D-printed food

Published Papers (1 paper)

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Emerging Trends in Biodegradable Microcarriers for Therapeutic Applications
Polymers 2023, 15(6), 1487; https://doi.org/10.3390/polym15061487 - 16 Mar 2023
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Microcarriers (MCs) are adaptable therapeutic instruments that may be adjusted to specific therapeutic uses, making them an appealing alternative for regenerative medicine and drug delivery. MCs can be employed to expand therapeutic cells. MCs can be used as scaffolds for tissue engineering, as [...] Read more.
Microcarriers (MCs) are adaptable therapeutic instruments that may be adjusted to specific therapeutic uses, making them an appealing alternative for regenerative medicine and drug delivery. MCs can be employed to expand therapeutic cells. MCs can be used as scaffolds for tissue engineering, as well as providing a 3D milieu that replicates the original extracellular matrix, facilitating cell proliferation and differentiation. Drugs, peptides, and other therapeutic compounds can be carried by MCs. The surface of the MCs can be altered, to improve medication loading and release, and to target specific tissues or cells. Allogeneic cell therapies in clinical trials require enormous volumes of stem cells, to assure adequate coverage for several recruitment locations, eliminate batch to batch variability, and reduce production costs. Commercially available microcarriers necessitate additional harvesting steps to extract cells and dissociation reagents, which reduces cell yield and quality. To circumvent such production challenges, biodegradable microcarriers have been developed. In this review, we have compiled key information relating to biodegradable MC platforms, for generating clinical-grade cells, that permit cell delivery at the target site without compromising quality or cell yields. Biodegradable MCs could also be employed as injectable scaffolds for defect filling, supplying biochemical signals for tissue repair and regeneration. Bioinks, coupled with biodegradable microcarriers with controlled rheological properties, might improve bioactive profiles, while also providing mechanical stability to 3D bioprinted tissue structures. Biodegradable materials used for microcarriers have the ability to solve in vitro disease modeling, and are advantageous to the biopharmaceutical drug industries, because they widen the spectrum of controllable biodegradation and may be employed in a variety of applications. Full article
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