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Polymers
Special Issues
Intranasal Delivery of Novel Polymeric Phamaceutic Formulations and Implants
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Special Issue "Intranasal Delivery of Novel Polymeric Phamaceutic Formulations and Implants"

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 3616

Special Issue Editors

Dr. Stavroula Nanaki

E-Mail Website1 Website2
Guest Editor
Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Interests: polymer chemistry; synthesis and modification of polymers; drug delivery systems
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Dimitrios Bikiaris

E-Mail Website
Guest Editor
Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, GR 54124 Thessaloniki, Greece
Interests: synthesis and characterization of polyesters; development of biobased polymers; biodegradable polymers; polymer composites and nanocomposites; synthesis and characterization of copolymers; polymer blends; recycling of polymers with various techniques; enzymatic hydrolysis studies; modification of natural polymers; polymer for wastewater treatment pollutant removal; polymers for tissue engineering and drug delivery applications; drug–polymer solid dispersions; drug targeting; drug nanoencapsulation and microencapsulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nose to brain delivery has gained significant scientific interest recently, bypassing disadvantages Furthermore, reduced frequency of dose and higher patient compliance renders the nasal route ideal for drug delivery.

Classic biocompatible and biodegradable polymers, such as PLGA and chitosan, have already been studied for their ability to deliver drugs through the nose. This Issue wishes to host novel synthesized polymers, and modified or grafted already-known polymers, ideal for drug administration through the nose.

All formulations concerning micro/nanoparticles, aerosols, as well as implants are expected to be part of this Special Issue. Reviews are also acceptable for publication.

Dr. Stavroula Nanaki
Prof. Dr. Dimitrios Bikiaris
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • intranasal delivery
  • polymer synthesis and characterization
  • drug administration
  • micro/nanoparticles
  • implants

Published Papers (2 papers)

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Article
L-Cysteine Modified Chitosan Nanoparticles and Carbon-Based Nanostructures for the Intranasal Delivery of Galantamine
by
Stavroula G. Nanaki
,
Konstantinos Spyrou
,
Pelagia Veneti
,
Niki Karouta
,
Dimitrios Gournis
,
Turki N. Baroud
,
Panagiotis Barmpalexis
and
Dimitrios N. Bikiaris
Polymers 2022, 14(19), 4004; https://doi.org/10.3390/polym14194004 - 24 Sep 2022
Cited by 2 | Viewed by 1560
Abstract
The present study evaluates the use of thiolized chitosan conjugates (CS) in combination with two fundamental carbon nanoforms (carbon dots (CDs) and Hierarchical Porous Carbons (HPC)) for the preparation of intranasally (IN) administrated galantamine (GAL) nanoparticles (NPs). Initially, the modification of CS with [...] Read more.
The present study evaluates the use of thiolized chitosan conjugates (CS) in combination with two fundamental carbon nanoforms (carbon dots (CDs) and Hierarchical Porous Carbons (HPC)) for the preparation of intranasally (IN) administrated galantamine (GAL) nanoparticles (NPs). Initially, the modification of CS with L-cysteine (Cys) was performed, and the successful formation of a Cys-CS conjugates was verified via 1H-NMR, FTIR, and pXRD. The new Cys-CS conjugate showed a significant solubility enhancement in neutral and alkaline pH, improving CS’s utility as a matrix-carrier for IN drug administration. In a further step, drug-loaded NPs were prepared via solid-oil–water double emulsification, and thoroughly analyzed by SEM, DLS, FTIR and pXRD. The results showed the formation of spherical NPs with a smooth surface, while the drug was amorphously dispersed within most of the prepared NPs, with the exemption of those systems contianing the CDs. Finally, in vitro dissolution release studies revealed that the prepared NPs could prolong GAL’s release for up to 12 days. In sum, regarding the most promising system, the results of the present study clearly suggest that the preparation of NPs using both Cys-CS and CDs results in a more thermodynamically stable drug dispersion, while a zero-order release profile was achieved, which is essential to attain a stable in vivo pharmacokinetic behavior. Full article
(This article belongs to the Special Issue Intranasal Delivery of Novel Polymeric Phamaceutic Formulations and Implants)
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Article
Synthesis and Evaluation of Thermoresponsive Renewable Lipid-Based Block Copolymers for Drug Delivery
by
Huiqi Wang
and
Aman Ullah
Polymers 2022, 14(17), 3436; https://doi.org/10.3390/polym14173436 - 23 Aug 2022
Cited by 5 | Viewed by 1672
Abstract
Polymeric micelle forming from self-assembly of amphiphilic macromolecules is one of the most potent drug delivery systems. Fatty acids, naturally occurring hydrophobic lipid components, can be considered as potential candidates for the fabrication of block copolymer micelles. However, examples of synthesis of responsive [...] Read more.
Polymeric micelle forming from self-assembly of amphiphilic macromolecules is one of the most potent drug delivery systems. Fatty acids, naturally occurring hydrophobic lipid components, can be considered as potential candidates for the fabrication of block copolymer micelles. However, examples of synthesis of responsive block copolymers using renewable fatty acids are scarce. Herein, we report the synthesis, characterization and testing of block copolymer micelles composed of a renewable fatty-acid-based hydrophobic block and thermoresponsive hydrophilic block for controlled drug delivery. The block copolymers of functionalized fatty acid and poly(N-isopropylacrylamide) (PNIPAM) were prepared via consecutive microwave-assisted reversible addition fragmentation chain transfer (RAFT) polymerization. The block copolymers with variable hydrophobic block length self-assembled in aqueous media and formed spherical nanoparticles of ~30 nm with low critical micelle concentration (CMC). To demonstrate the proof-of-concept, carbamazepine (CBZ) was used as a hydrophobic model drug to evaluate the performance of these micelles as nanocarriers. The in vitro drug release tests were carried out below (25 °C) and above (37 °C) the lower critical solution temperature (LCST) of the block copolymer. The drug release showed obvious temperature-triggered response and an accelerated drug release at 37 °C. Full article
(This article belongs to the Special Issue Intranasal Delivery of Novel Polymeric Phamaceutic Formulations and Implants)
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