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Polymers
Special Issues
Advanced Polymeric Biomaterial and Oral Biology
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Advanced Polymeric Biomaterial and Oral Biology

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (25 August 2023) | Viewed by 4496

Special Issue Editor

Prof. Dr. Shu-Fen Chuang

E-Mail Website
Guest Editor
Institute of Oral Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 70403, Taiwan
Interests: dental restorative materials; biomechanics of dental materials; oral biology

Special Issue Information

Dear Colleagues,

Oral biology involves studying the unique combination of tissues and functions of the mouth and craniofacial complex. Polymer biomaterials are widely used as dental materials given their biocompatibility, light weight and excellent mechanical properties.

It is with great pleasure that we invite you to submit a manuscript related to oral biology for this Special Issue, which includes papers related—but not limited—to dental materials, bioadhesives, bleaching materials, restorers or regenerators. Remarkable contributions including research articles, communications and reviews from experts all over the world are welcome.

Prof. Dr. Shu-Fen Chuang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • dental materials
  • functional materials
  • oral biology
  • tissue reaction
  • regeneration
  • restoration

Published Papers (2 papers)

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Research

22 pages, 5378 KiB  
Article
Biomimetic Hydroxyapatite Crystals Growth on Phosphorylated Chitosan Films by In Vitro Mineralization Used as Dental Substitute Materials
by Fathia Rahmani, Omar Larbi Bouamrane, Amina Ben Bouabdallah, Leonard I. Atanase, Abdelkader Hellal and Aurelian Nichita Apintiliesei
Polymers 2023, 15(11), 2470; https://doi.org/10.3390/polym15112470 - 26 May 2023
Cited by 2 | Viewed by 1206
Abstract
Chitosan (CS) films exhibit great potential as a substrate for the in vitro mineralization process. In this study, to mimic the formation of nanohydroxyapatite (HAP) as natural tissue, CS films coated with a porous calcium phosphate were investigated using scanning electron microscopy (SEM), [...] Read more.
Chitosan (CS) films exhibit great potential as a substrate for the in vitro mineralization process. In this study, to mimic the formation of nanohydroxyapatite (HAP) as natural tissue, CS films coated with a porous calcium phosphate were investigated using scanning electron microscopy (SEM), Energy dispersive X-ray spectroscopy (EDX), Fourier transforms infrared spectroscopy (FTIR), X-ray diffractometry (XRD) and X-ray photoelectron spectroscopy (XPS). Calcium phosphate coating deposited on phosphorylated derivatives of CS was obtained by a process based on phosphorylation, Ca(OH)2 treatment and artificial saliva solution (ASS) immersion. The phosphorylated CS films (PCS) were obtained by partial hydrolysis of the PO4 functionalities. It was demonstrated that this precursor phase could induce the growth and the nucleation of the porous calcium phosphate coating when immersed in ASS. Moreover, oriented crystals and qualitative control of calcium phosphate phases on CS matrices are obtained in a biomimetic mode. Furthermore, in vitro antimicrobial activity of PCS was evaluated against three species of oral bacteria and fungi. It revealed an increase in antimicrobial activity with minimum inhibition concentration (MIC) values of 0.10% (Candida albicans), 0.05% (Staphylococcus aureus) and 0.025% (Escherichia coli) which proves their possible use as dental substitute materials. Full article
(This article belongs to the Special Issue Advanced Polymeric Biomaterial and Oral Biology)
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16 pages, 4950 KiB  
Article
Dentin Sialoprotein/Phosphophoryn (DSP/PP) as Bio-Inductive Materials for Direct Pulp Capping
by Shu-Fen Chuang, Yu-Hsuan Chen, Peter X. Ma and Helena H. Ritchie
Polymers 2022, 14(17), 3656; https://doi.org/10.3390/polym14173656 - 03 Sep 2022
Cited by 3 | Viewed by 2796
Abstract
Conventional direct pulp capping, such as calcium hydroxide (Ca(OH)2) or silicate products, usually induces an inflammatory reaction to provoke pulp regeneration. Phosphophoryn (PP) and dentin sialoprotein (DSP), the two most abundant non-collagenous proteins in the dentin matrix, are responsible for dentin [...] Read more.
Conventional direct pulp capping, such as calcium hydroxide (Ca(OH)2) or silicate products, usually induces an inflammatory reaction to provoke pulp regeneration. Phosphophoryn (PP) and dentin sialoprotein (DSP), the two most abundant non-collagenous proteins in the dentin matrix, are responsible for dentin mineralization, pulp cell migration, and differentiation. Here we examined the PP and combined DSP/PP as bio-inductive pulp capping materials by in vitro and in vivo tests. Firstly, the effects of the PP dose on pulp cell migration and matrix protein expression were examined by an agarose bead test. Secondly, the role of recombinant DSP (recDSP) and recDSP/PP on stimulating DSP-PP transcript expression was examined by RT-PCR. DSPP mRNA was also knocked down by RNA interference (RNAi) to examine their functions on dentin matrix mineralization. Finally, we used ferret animal models to test PP and recDSP/PP acting as capping agents on in vivo pulp responses and reparative dentin formation. The result showed that intermediate-dose PP was the most effective to enhance cell migration and differentiation. RecDSP/PP strongly enhanced the DSP-PP transcript expression, while inhibition of DSPP mRNA expression by siRNAs partially or completely affected dental pulp cell mineralization. The in vivo results showed that intermediate-dose PP and recDSP/PP proteins induced less pulp inflammation and promoted reparative dentin formation. Contrarily, conventional calcium hydroxide induced severe pulp inflammation. With these findings, DSP and PP could serve as capping agents for pulp capping therapy. Full article
(This article belongs to the Special Issue Advanced Polymeric Biomaterial and Oral Biology)
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