Biomaterials for Bone/Teeth Regeneration Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (25 October 2023) | Viewed by 3634

Special Issue Editors


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Guest Editor
School of Dental Technology, College of Oral College, Taipei Medical University, Taipei 110, Taiwan
Interests: 3D scaffold; biomaterials micro/nano fabrication; 3D/4D printing & bioprinting
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Guest Editor
School of Dental Technology, College of Oral College, Taipei Medical University, Taipei 110, Taiwan
Interests: bioglass; scaffold; 3D bioprint

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Guest Editor
School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan
Interests: dental technology; digital dentistry; dental prosthesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomaterials (also known as biomedical materials) are new innovative high-tech materials used to diagnose, treat, repair, or replace human tissues, organs or enhance their functions. They touch the health of hundreds of millions of people and are vital to human health. Their application not only saves the lives of tens of millions of critically ill patients, but also significantly reduces the mortality rate of major diseases, such as cancer, cardiovascular disease, and trauma, improving the quality of life and health of patients, and reducing medical costs. The development of biomaterials also guides the innovation of contemporary medical technology and the development of medical and health services. For example, the research and development of vascular stents, interventional catheters, and instruments has promoted the formation and development of minimally invasive interventional therapy technologies. The development of carrier materials for targeted/intelligent controlled release systems of active substances (such as proteins, drugs, genes, etc.) will not only bring about revolutionary changes in traditional drug delivery methods, but also lead to congenital genetic defects, geriatric diseases, diseases, etc. Oncology and refractory treatments will open up new avenues.

Regeneration or reconstruction of bone/teeth function using tissue engineering techniques often needs biomaterials. Traditionally, these materials have used ceramics, metals, and polymers, but bone/teeth itself is a composite material. Therefore, it is important to know how to use the right biomaterials. The different kinds of materials and their percentage composition in biomaterials are the first level, followed by the properties of biomaterials (such as surface properties, surface roughness, strength, hardness, porosity, pH, degradation properties) that affect their applications. Cell cultures and animal experiments of biomaterials are used to determine future suitability for humans. The interaction of cells with biomaterials is very important in cell culture. Microscale patterns of cells and their environment must be emphasized in cell culture. This Special Issue welcomes innovative research on the application of biomaterials in bone/teeth regeneration or reconstruction.

Prof. Dr. Yung-Kang Shen
Dr. Fang-Yu Fan
Dr. Wei-Chun Lin
Guest Editors

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Keywords

  • biomaterials
  • material composition and percentage
  • material characteristics
  • cell patterning
  • animal model
  • bone/teeth regeneration or reconstruction
  • materials processing

Published Papers (2 papers)

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Research

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13 pages, 2633 KiB  
Article
A Three-Dimensional Bioprinted Copolymer Scaffold with Biocompatibility and Structural Integrity for Potential Tissue Regeneration Applications
by Bou-Yue Peng, Keng-Liang Ou, Chung-Ming Liu, Shu-Fen Chu, Bai-Hung Huang, Yung-Chieh Cho, Takashi Saito, Chi-Hsun Tsai, Kuo-Sheng Hung and Wen-Chien Lan
Polymers 2022, 14(16), 3415; https://doi.org/10.3390/polym14163415 - 21 Aug 2022
Cited by 4 | Viewed by 1841
Abstract
The present study was to investigate the rheological property, printability, and cell viability of alginate–gelatin composed hydrogels as a potential cell-laden bioink for three-dimensional (3D) bioprinting applications. The 2 g of sodium alginate dissolved in 50 mL of phosphate buffered saline solution was [...] Read more.
The present study was to investigate the rheological property, printability, and cell viability of alginate–gelatin composed hydrogels as a potential cell-laden bioink for three-dimensional (3D) bioprinting applications. The 2 g of sodium alginate dissolved in 50 mL of phosphate buffered saline solution was mixed with different concentrations (1% (0.5 g), 2% (1 g), 3% (1.5 g), and 4% (2 g)) of gelatin, denoted as GBH-1, GBH-2, GBH-3, and GBH-4, respectively. The properties of the investigated hydrogels were characterized by contact angle goniometer, rheometer, and bioprinter. In addition, the hydrogel with a proper concentration was adopted as a cell-laden bioink to conduct cell viability testing (before and after bioprinting) using Live/Dead assay and immunofluorescence staining with a human corneal fibroblast cell line. The analytical results indicated that the GBH-2 hydrogel exhibited the lowest loss rate of contact angle (28%) and similar rheological performance as compared with other investigated hydrogels and the control group. Printability results also showed that the average wire diameter of the GBH-2 bioink (0.84 ± 0.02 mm (*** p < 0.001)) post-printing was similar to that of the control group (0.79 ± 0.05 mm). Moreover, a cell scaffold could be fabricated from the GBH-2 bioink and retained its shape integrity for 24 h post-printing. For bioprinting evaluation, it demonstrated that the GBH-2 bioink possessed well viability (>70%) of the human corneal fibroblast cell after seven days of printing under an ideal printing parameter combination (0.4 mm of inner diameter needle, 0.8 bar of printing pressure, and 25 °C of printing temperature). Therefore, the present study suggests that the GBH-2 hydrogel could be developed as a potential cell-laden bioink to print a cell scaffold with biocompatibility and structural integrity for soft tissues such as skin, cornea, nerve, and blood vessel regeneration applications. Full article
(This article belongs to the Special Issue Biomaterials for Bone/Teeth Regeneration Applications)
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Review

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34 pages, 3619 KiB  
Review
A 3D-Printed Scaffold for Repairing Bone Defects
by Jianghui Dong, Hangxing Ding, Qin Wang and Liping Wang
Polymers 2024, 16(5), 706; https://doi.org/10.3390/polym16050706 - 05 Mar 2024
Viewed by 1135
Abstract
The treatment of bone defects has always posed challenges in the field of orthopedics. Scaffolds, as a vital component of bone tissue engineering, offer significant advantages in the research and treatment of clinical bone defects. This study aims to provide an overview of [...] Read more.
The treatment of bone defects has always posed challenges in the field of orthopedics. Scaffolds, as a vital component of bone tissue engineering, offer significant advantages in the research and treatment of clinical bone defects. This study aims to provide an overview of how 3D printing technology is applied in the production of bone repair scaffolds. Depending on the materials used, the 3D-printed scaffolds can be classified into two types: single-component scaffolds and composite scaffolds. We have conducted a comprehensive analysis of material composition, the characteristics of 3D printing, performance, advantages, disadvantages, and applications for each scaffold type. Furthermore, based on the current research status and progress, we offer suggestions for future research in this area. In conclusion, this review acts as a valuable reference for advancing the research in the field of bone repair scaffolds. Full article
(This article belongs to the Special Issue Biomaterials for Bone/Teeth Regeneration Applications)
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