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Polymers
Special Issues
Biodegradable Polymeric Implants for Drug Delivery and Cell Therapy Applications
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Biodegradable Polymeric Implants for Drug Delivery and Cell Therapy Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (10 March 2023) | Viewed by 12309

Special Issue Editors

Dr. Panita Maturavongsadit

E-Mail Website
Guest Editor
Joint Department of Biomedical Engineering at University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC 27599-3290, USA
Interests: biomaterials; biomimetic nanomaterials; drug delivery; tissue engineering; cell/therapeutic-material interaction; and 3d bioprinting
Dr. Narsimha Mamidi

E-Mail Website
Guest Editor
School of Engineering and Sciences, Tecnologico de Monterrey, Monterrey, Nuevo Leon 64849, Mexico
Interests: biomaterials; nanomedicine; immunotherapy; advanced drug delivery formulations; biomedical applications; drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The use of biodegradable polymeric biomaterials for controlled drug delivery and cell therapy holds promise as a therapeutic option to improve treatment outcomes and patient compliance for various diseases. Hydrogels have become one of the most promising fields in drug/cell delivery systems due to their remarkable properties resembling living tissues and good biocompatibility with high tunability in physicochemical/biological properties. Many biodegradable hydrogel systems created by natural or synthetic polymers have been successfully developed to achieve therapeutic efficacy and minimize side effects while improving patient compliance. Moreover, various biofabrication technologies, such as microfluidics, 3D bioprinting, and electrospinning, have been applied in recent years to create hydrogels that can prolong the half-life of therapeutic cells from body clearance and avoid the immune recognition and emulate the natural cellular microenvironment for various cell therapy applications.

This Special Issue welcomes original research and review articles and aims to promote the recent advances in innovative biodegradable polymeric biomaterials for controlled drug/cell delivery. The potential topics include, but are not limited to, the following: 1) designing and developing implantable biodegradable polymeric biomaterials for drug/cell delivery utilizing various advanced polymer and/or nanoparticle technologies, such as stimuli-responsive synthetic and biopolymers; 2) manufacturing and processing biodegradable polymeric implants utilizing biofabrication technologies, such as microfluidics, 3D bioprinting and electrospinning for drug/cell delivery.

Dr. Panita Maturavongsadit
Dr. Narsimha Mamidi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biodegradable biomaterials
  • stimuli-responsive polymers
  • smart materials
  • nanomaterials
  • hydrogels
  • in-situ forming implants
  • long-acting delivery
  • controlled drug delivery
  • stem cell therapy
  • tissue regeneration

Published Papers (4 papers)

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Research

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15 pages, 2985 KiB  
Article
Influence of Polyols on the In Vitro Biodegradation and Bioactivity of 58S Bioactive Sol–Gel Coatings on AZ31B Magnesium Alloys
by Ashok Raja Chandrasekar, Emilia Merino, Amirhossein Pakseresht, Dusan Galusek, Alicia Duran and Yolanda Castro
Polymers 2023, 15(5), 1273; https://doi.org/10.3390/polym15051273 - 02 Mar 2023
Cited by 2 | Viewed by 1849
Abstract
The mechanical qualities of AZ31B magnesium alloys make them a promising material for biodegradable metallic implants. However, rapid degradation limits the application of these alloys. In the present study, 58S bioactive glasses were synthesized using the sol-gel method and several polyols such as [...] Read more.
The mechanical qualities of AZ31B magnesium alloys make them a promising material for biodegradable metallic implants. However, rapid degradation limits the application of these alloys. In the present study, 58S bioactive glasses were synthesized using the sol-gel method and several polyols such as glycerol, ethylene glycol, and polyethylene glycol, were used to improve the sol stability and to control the degradation of AZ31B. The synthesized bioactive sols were dip-coated onto AZ31B substrates and then, characterized by various techniques such as scanning electron microscopy (SEM), X-ray diffraction (XRD) and electrochemical techniques (potentiodynamic and electrochemical impedance spectroscopy), among them. FTIR analysis confirmed the formation of a silica, calcium, and phosphate system and the XRD the amorphous nature of the 58S bioactive coatings obtained by sol-gel. The contact angle measurements confirmed that all the coatings were hydrophilic. The biodegradability response under physiological conditions (Hank’s solution) was investigated for all the 58S bioactive glass coatings, observing a different behaviour depending on the polyols incorporated. Thus, for 58S PEG coating, an efficient control of the release of H2 gas was observed, and showing a pH control between 7.6 and 7.8 during all the tests. A marked apatite precipitation was also observed on the surface of the 58S PEG coating after the immersion test. Thus, the 58S PEG sol-gel coating is considered a promising alternative for biodegradable magnesium alloy-based medical implants. Full article
(This article belongs to the Special Issue Biodegradable Polymeric Implants for Drug Delivery and Cell Therapy Applications)
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18 pages, 81824 KiB  
Article
In Vivo Biocompatible Self-Assembled Nanogel Based on Hyaluronic Acid for Aqueous Solubility and Stability Enhancement of Asiatic Acid
by Yu Yu Win, Penpimon Charoenkanburkang, Vudhiporn Limprasutr, Ratchanee Rodsiri, Yue Pan, Visarut Buranasudja and Jittima Amie Luckanagul
Polymers 2021, 13(23), 4071; https://doi.org/10.3390/polym13234071 - 23 Nov 2021
Cited by 10 | Viewed by 3832
Abstract
Asiatic acid (AA), a natural triterpene found in Centalla asiatica, possesses polypharmacological properties that can contribute to the treatment and prophylaxis of various diseases. However, its hydrophobic nature and rapid metabolic rate lead to poor bioavailability. The aim of this research was [...] Read more.
Asiatic acid (AA), a natural triterpene found in Centalla asiatica, possesses polypharmacological properties that can contribute to the treatment and prophylaxis of various diseases. However, its hydrophobic nature and rapid metabolic rate lead to poor bioavailability. The aim of this research was to develop a thermoresponsive nanogel from hyaluronic acid (HA) for solubility and stability enhancement of AA. Poly(N-isopropylacrylamide) (pNIPAM) was conjugated onto HA using a carbodiimide reaction followed by 1H NMR characterization. pNIPAM-grafted HA (HA-pNIPAM) nanogels were prepared with three concentrations of polymer, 0.1, 0.15 and 0.25% w/v, in water by the sonication method. AA was loaded into the nanogel by the incubation method. Size, morphology, AA loading capacity and encapsulation efficiency (EE) were analyzed. In vitro cytocompatibility was evaluated in fibroblast L-929 cells using the PrestoBlue assay. Single-dose toxicity was studied using rats. HA-pNIPAM nanogels at a 4.88% grafting degree showed reversible thermo-responsive behavior. All nanogel formulations could significantly increase AA water solubility and the stability was higher in nanogels prepared with high polymer concentrations over 180 days. The cell culture study showed that 12.5 µM AA in nanogel formulations was considered non-toxic to the L-929 cells; however, a dose-dependent cytotoxic effect was observed at higher AA-loaded concentrations. In vivo study proved the non-toxic effect of AA loaded in HA-pNIPAM nanogels compared with the control. Taken together, HA-pNIPAM nanogel is a promising biocompatible delivery system both in vitro and in vivo for hydrophobic AA molecules. Full article
(This article belongs to the Special Issue Biodegradable Polymeric Implants for Drug Delivery and Cell Therapy Applications)
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Review

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15 pages, 7414 KiB  
Review
Recent Progress on Heparin–Protamine Particles for Biomedical Application
by Yuuki Hata, Hiromi Miyazaki, Masayuki Ishihara and Shingo Nakamura
Polymers 2022, 14(5), 932; https://doi.org/10.3390/polym14050932 - 25 Feb 2022
Cited by 6 | Viewed by 2240
Abstract
Biomolecules are attractive building blocks with self-assembly ability, structural diversity, and excellent functionality for creating artificial materials. Heparin and protamine, a clinically relevant pair of biomolecules used in cardiac and vascular surgery, have been shown to coassemble into particulate polyelectrolyte complexes in vitro. [...] Read more.
Biomolecules are attractive building blocks with self-assembly ability, structural diversity, and excellent functionality for creating artificial materials. Heparin and protamine, a clinically relevant pair of biomolecules used in cardiac and vascular surgery, have been shown to coassemble into particulate polyelectrolyte complexes in vitro. The resulting heparin–protamine particles exhibit adhesive properties that enable advantageous interactions with proteins, cells, and various other substances and have been employed as functional materials for biomedical applications. In this review article, we summarize recent progress in research on the use of heparin–protamine particles as drug carriers, cell adhesives, and cell labels. Studies have demonstrated that heparin–protamine particles are potentially versatile in biomedical fields from drug delivery and regenerative medicine to plastic surgery. Full article
(This article belongs to the Special Issue Biodegradable Polymeric Implants for Drug Delivery and Cell Therapy Applications)
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24 pages, 1844 KiB  
Review
The Potential Contribution of Biopolymeric Particles in Lung Tissue Regeneration of COVID-19 Patients
by Mohamed Abbas, Mohammed S. Alqahtani, Hussain M. Almohiy, Fawaz F. Alqahtani, Roaa Alhifzi and Layal K. Jambi
Polymers 2021, 13(22), 4011; https://doi.org/10.3390/polym13224011 - 20 Nov 2021
Cited by 1 | Viewed by 3136
Abstract
The lung is a vital organ that houses the alveoli, which is where gas exchange takes place. The COVID-19 illness attacks lung cells directly, creating significant inflammation and resulting in their inability to function. To return to the nature of their job, it [...] Read more.
The lung is a vital organ that houses the alveoli, which is where gas exchange takes place. The COVID-19 illness attacks lung cells directly, creating significant inflammation and resulting in their inability to function. To return to the nature of their job, it may be essential to rejuvenate the afflicted lung cells. This is difficult because lung cells need a long time to rebuild and resume their function. Biopolymeric particles are the most effective means to transfer developing treatments to airway epithelial cells and then regenerate infected lung cells, which is one of the most significant symptoms connected with COVID-19. Delivering biocompatible and degradable natural biological materials, chemotherapeutic drugs, vaccines, proteins, antibodies, nucleic acids, and diagnostic agents are all examples of these molecules‘ usage. Furthermore, they are created by using several structural components, which allows them to effectively connect with these cells. We highlight their most recent uses in lung tissue regeneration in this review. These particles are classified into three groups: biopolymeric nanoparticles, biopolymeric stem cell materials, and biopolymeric scaffolds. The techniques and processes for regenerating lung tissue will be thoroughly explored. Full article
(This article belongs to the Special Issue Biodegradable Polymeric Implants for Drug Delivery and Cell Therapy Applications)
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