Electrospun Nanofibers

A topical collection in Polymers (ISSN 2073-4360). This collection belongs to the section "Polymer Applications".

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Editors

Romania Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa"—Iași, 700115 Iasi, Romania
Interests: nanofibers; natural polymers; tissue engineering, wound dressing; release profile; antioxidant activity
Special Issues, Collections and Topics in MDPI journals
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, 16 University Street, 700115 Iasi, Romania
Interests: chitosan-tripolyphosphate; chitosan; drug delivery systems
Special Issues, Collections and Topics in MDPI journals

Topical Collection Information

Dear Colleagues,

The topic of electrospun nanofiber is a very innovative one, so the number of scientific papers on nanotechnology is constantly growing. Due to their unique properties, such as: high porosity and high surface-to-volume ratio make them versatile formulations that find applicability in various fields: physical, material, bio-engineering sciences or medical and pharmaceutical sciences. Thus, in this Topical Collection, we want to allow the researchers to disseminate their results carried out on different types of electrospun nanofibers and on the use of electrospinning in the formulation of these ground-breaking formulations.

Topics of interest for this Topical Collection include, yet are not limited to, the following:

  • Design, formulation, and characterization of different polymer nanofibers;
  • Electrospinning process;
  • Application of novel nanofibers;
  • Other topics highlighting the methodology providing advances in the field of the polymer electrospun nanofibers.

Dr. Andreea Iacob
Prof. Dr. Lenuta Profire
Collection Editors

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Keywords

  • electrospun nanofibers
  • electrospinning
  • design and characterization
  • formulation and application of electrospun nanofibers
  • polymers in electrospinning
  • chemical properties
  • physical properties
  • polymer chain structure
  • polymeric materials
  • medical application

Published Papers (6 papers)

2024

Jump to: 2023, 2022

34 pages, 7171 KiB  
Article
Fabrication and Optimization of Electrospun Shellac Fibers Loaded with Senna alata Leaf Extract
by Wah Wah Aung, Wantanwa Krongrawa, Sontaya Limmatvapirat, Pattranit Kulpicheswanich, Siriporn Okonogi and Chutima Limmatvapirat
Polymers 2024, 16(2), 183; https://doi.org/10.3390/polym16020183 - 08 Jan 2024
Viewed by 775
Abstract
Single-fluid electrospinning creates nanofibers from molten polymer solutions with active ingredients. This study utilized a combination of a fractional factorial design and a Box–Behnken design to examine crucial factors among a multitude of parameters and to optimize the electrospinning conditions that impact fiber [...] Read more.
Single-fluid electrospinning creates nanofibers from molten polymer solutions with active ingredients. This study utilized a combination of a fractional factorial design and a Box–Behnken design to examine crucial factors among a multitude of parameters and to optimize the electrospinning conditions that impact fiber mats’ morphology and the entrapment efficiency of Senna alata leaf extract. The findings indicated that the shellac content had the greatest impact on both fiber diameter and bead formation. The optimum electrospinning conditions were identified as a voltage of 24 kV, a solution feed rate of 0.8 mL/h, and a shellac–extract ratio of 38.5:3.8. These conditions produced nanosized fibers with a diameter of 306 nm, a low bead-to-fiber ratio of 0.29, and an extract entrapment efficiency of 96% within the fibers. The biphasic profile of the optimized nanofibers was confirmed with an in vitro release study. This profile consisted of an initial burst release of 88% within the first hour, which was succeeded by a sustained release pattern surpassing 90% for the next 12 h, as predicted with zero-order release kinetics. The optimized nanofibers demonstrated antimicrobial efficacy against diverse pathogens, suggesting promising applications in wound dressings and protective textiles. Full article
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Graphical abstract

2023

Jump to: 2024, 2022

16 pages, 2850 KiB  
Article
A Study of the Relationship between Polymer Solution Entanglement and Electrospun PCL Fiber Mechanics
by Manasa Rajeev and Christine C. Helms
Polymers 2023, 15(23), 4555; https://doi.org/10.3390/polym15234555 - 28 Nov 2023
Viewed by 716
Abstract
Electrospun fibers range in size from nanometers to micrometers and have a multitude of potential applications that depend upon their morphology and mechanics. In this paper, we investigate the effect of polymer solution entanglement on the mechanical properties of individual electrospun polycaprolactone (PCL) [...] Read more.
Electrospun fibers range in size from nanometers to micrometers and have a multitude of potential applications that depend upon their morphology and mechanics. In this paper, we investigate the effect of polymer solution entanglement on the mechanical properties of individual electrospun polycaprolactone (PCL) fibers. Multiple concentrations of PCL, a biocompatible polymer, were dissolved in a minimum toxicity solvent composed of acetic acid and formic acid. The number of entanglements per polymer (ne) in solution was calculated using the polymer volume fraction, and the resultant electrospun fiber morphology and mechanics were measured. Consistent electrospinning of smooth fibers was achieved for solutions with ne ranging from 3.8 to 4.9, and the corresponding concentration of 13 g/dL to 17 g/dL PCL. The initial modulus of the resultant fibers did not depend upon polymer entanglement. However, the examination of fiber mechanics at higher strains, performed via lateral force atomic force microscopy (AFM), revealed differences among the fibers formed at various concentrations. Average fiber extensibility increased by 35% as the polymer entanglement number increased from a 3.8 ne solution to a 4.9 ne solution. All PCL fibers displayed strain-hardening behavior. On average, the stress increased with strain to the second power. Therefore, the larger extensibilities at higher ne also led to a more than double increase in fiber strength. Our results support the role of polymer entanglement in the mechanical properties of electrospun fiber at large strains. Full article
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14 pages, 7915 KiB  
Article
Morphology Control of Electrospun Brominated Butyl Rubber Microfibrous Membrane
by Tianxiao Zhu, Ruizhi Tian, Liang Wu, Dingyi Zhang, Leying Chen, Xianmei Zhang, Xiangyang Hao and Ping Hu
Polymers 2023, 15(19), 3909; https://doi.org/10.3390/polym15193909 - 27 Sep 2023
Viewed by 777
Abstract
Brominated butyl rubber (BIIR) is a derivative of butyl rubber, with the advantage of high physical strength, good vibration damping performance, low permeability, aging resistance, weather resistance, etc. However, it is hard to avoid BIIR fiber sticking together due to serious swelling or [...] Read more.
Brominated butyl rubber (BIIR) is a derivative of butyl rubber, with the advantage of high physical strength, good vibration damping performance, low permeability, aging resistance, weather resistance, etc. However, it is hard to avoid BIIR fiber sticking together due to serious swelling or merging, resulting in few studies on BIIR electrospinning. In this work, brominated butyl rubber membrane (mat) with BIIR microfiber has been prepared by electrospinning. The spinnability of elastomer BIIR has been explored. The factors influencing the morphology of BIIR microfiber membranes have been studied, including solvent, electrospinning parameters, concentration, and the rheological property of electrospinning solution. The optimal parameters for electrospinning BIIR have been obtained. A BIIR membrane with the ideal microfiber morphology has been obtained, which can be peeled from aluminum foil on a collector easily without being broken. Anti-bacterial property, the electrical conductivity of these membranes, and the mechanical properties of these samples were studied. The optimized BIIR electrospinning solution is Bingham fluid. The results of these experiments show that a BIIR membrane can be used in the field of medical prevention, wearable electronics, electronic skin, and in other fields that require antibacterial functional polymer materials. Full article
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14 pages, 7502 KiB  
Article
Electrospun Poly(L-Lactic Acid)/Gelatin Hybrid Polymer as a Barrier to Periodontal Tissue Regeneration
by Youngchae Cho, Heeseok Jeong, Baeyeon Kim, Juwoong Jang, Yo-Seung Song and Deuk Yong Lee
Polymers 2023, 15(18), 3844; https://doi.org/10.3390/polym15183844 - 21 Sep 2023
Cited by 2 | Viewed by 901
Abstract
Poly(L-lactic acid) (PLLA) and PLLA/gelatin polymers were prepared via electrospinning to evaluate the effect of PLLA and gelatin content on the mechanical properties, water uptake capacity (WUC), water contact angle (WCA), degradation rate, cytotoxicity and cell proliferation of membranes. As the PLLA concentration [...] Read more.
Poly(L-lactic acid) (PLLA) and PLLA/gelatin polymers were prepared via electrospinning to evaluate the effect of PLLA and gelatin content on the mechanical properties, water uptake capacity (WUC), water contact angle (WCA), degradation rate, cytotoxicity and cell proliferation of membranes. As the PLLA concentration increased from 1 wt% to 3 wt%, the tensile strength increased from 5.8 MPa to 9.1 MPa but decreased to 7.0 MPa with 4 wt% PLLA doping. The WUC decreased rapidly from 594% to 236% as the PLLA content increased from 1 to 4 wt% due to the increased hydrophobicity of PLLA. As the gelatin content was increased to 3 wt% PLLA, the strength, WUC and WCA of the PLLA/gelatin membrane changed from 9.1 ± 0.9 MPa to 13.3 ± 2.3 MPa, from 329% to 1248% and from 127 ± 1.2° to 0°, respectively, with increasing gelatin content from 0 to 40 wt%. However, the failure strain decreased from 3.0 to 0.5. The biodegradability of the PLLA/gelatin blend increased from 3 to 38% as the gelatin content increased to 40 wt%. The viability of L-929 and MG-63 cells in the PLLA/gelatin blend was over 95%, and the excellent cell proliferation and mechanical properties suggested that the tunable PLLA/gelatin barrier membrane was well suited for absorbable periodontal tissue regeneration. Full article
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13 pages, 3582 KiB  
Article
Explicit Expressions for a Mean Nanofibre Diameter Using Input Parameters in the Process of Electrospinning
by Petr Filip
Polymers 2023, 15(16), 3371; https://doi.org/10.3390/polym15163371 - 11 Aug 2023
Viewed by 675
Abstract
The process of electrospinning is subject to a variety of input parameters ranging from the characterization of polymers and solvents, the resulting solutions, the geometrical configuration of the device, including its process parameters, and ending with crucial parameters such as temperature and humidity. [...] Read more.
The process of electrospinning is subject to a variety of input parameters ranging from the characterization of polymers and solvents, the resulting solutions, the geometrical configuration of the device, including its process parameters, and ending with crucial parameters such as temperature and humidity. It is not possible to expect that functional expressions relating all these parameters can be derived in a common description. Nevertheless, it is possible to fix the majority of these parameters to derive explicit relations for a restricted number of entry parameters such that it contributes to the partial elimination of the classical trial-and-error method saving time and financial costs. However, several contributions providing such results are rather moderate. Special attention is provided to fibre diameter approximation as this parameter strongly influences the application of nanofibrous mats in various instances such as air filtration, tissue engineering, and drug delivery systems. Various difficulties connected with the derivation of these explicit relations are presented and discussed in detail. Full article
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2022

Jump to: 2024, 2023

29 pages, 4836 KiB  
Review
Electrospun Nanofiber Composites for Drug Delivery: A Review on Current Progresses
by Renatha Jiffrin, Saiful Izwan Abd Razak, Mohamad Ikhwan Jamaludin, Amir Syahir Amir Hamzah, Muadz Ahmad Mazian, Muhammad Azan Tamar Jaya, Mohammed Z. Nasrullah, Mohammed Majrashi, Abdulrahman Theyab, Ahmed A. Aldarmahi, Zuhier Awan, Mohamed M. Abdel-Daim and Abul Kalam Azad
Polymers 2022, 14(18), 3725; https://doi.org/10.3390/polym14183725 - 07 Sep 2022
Cited by 21 | Viewed by 3845
Abstract
A medication’s approximate release profile should be sustained in order to generate the desired therapeutic effect. The drug’s release site, duration, and rate must all be adjusted to the drug’s therapeutic aim. However, when designing drug delivery systems, this may be a considerable [...] Read more.
A medication’s approximate release profile should be sustained in order to generate the desired therapeutic effect. The drug’s release site, duration, and rate must all be adjusted to the drug’s therapeutic aim. However, when designing drug delivery systems, this may be a considerable hurdle. Electrospinning is a promising method of creating a nanofibrous membrane since it enables drugs to be placed in the nanofiber composite and released over time. Nanofiber composites designed through electrospinning for drug release purposes are commonly constructed of simple structures. This nanofiber composite produces matrices with nanoscale fiber structure, large surface area to volume ratio, and a high porosity with small pore size. The nanofiber composite’s large surface area to volume ratio can aid with cell binding and multiplication, drug loading, and mass transfer processes. The nanofiber composite acts as a container for drugs that can be customized to a wide range of drug release kinetics. Drugs may be electrospun after being dissolved or dispersed in the polymer solution, or they can be physically or chemically bound to the nanofiber surface. The composition and internal structure of the nanofibers are crucial for medicine release patterns. Full article
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