Tailored Biopolymer Gels: Functionalization, Structure, and Application

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 1306

Special Issue Editors


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Guest Editor
Institute for Polymers, Composites and Biomaterials – National Research Council of Italy, Rome, Italy
Interests: dynamics and rheology of soft materials; biopolymer gels; drug delivery; supercritical-CO2 for aerogels; diffusion in polymeric matrices

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Guest Editor
Department of Chemical Sciences, Università degli Studi di Napoli Federico II, Naples, Italy
Interests: original approaches for selective modifications of carbohydrates and multi-functionalized compounds; new methods and strategies for oligosaccharide synthesis; original routes to bioactive targets
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Special Issue Information

Dear Colleagues,

There is a growing interest in gels, particularly for those based on biopolymers—that is, natural polymers from the cells of living organisms. The main thrust comes from the possibility of using these systems in different fields, ranging from foods to cosmetics, from pharmaceuticals to biomedicals. The variety of prospects offered by these soft materials makes them extremely interesting from a research point of view: chemically, through the presence of easily modifiable chemical groups which makes it possible to alter and enhance their functionality (e.g., by responding to specific stimuli); physically, for the possibility of combining information at different length scales to obtain their ultimate properties; and finally, from an engineering point of view, for the ability to tailor their properties by modulating the underlying interactions. Such peculiarities make biopolymer-based gels a popular topic in polymer science.
The topics covered by this Special Issue range different disciplinary fields. For example, the functionalization of biopolymer gels for targeted uses, the relationship between gel structure and ultimate properties, and the tailoring of materials for specific applications.

Prof. Dr. Domenico Larobina
Prof. Dr. Alfonso Iadonisi
Guest Editors

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Keywords

  • biopolymer gels
  • functionalization
  • gel structure
  • mechanical characterization
  • dynamic characterization
  • bio-responsive gels
  • application of biopolymer gels

Published Papers (1 paper)

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Research

15 pages, 2839 KiB  
Article
Fermentation-Derived Albumin-Based Hydrogels for Tissue Adhesion Applications
by Francesca Della Sala, Birgitte Mølholm Malle, Luigi Ambrosio and Assunta Borzacchiello
Polymers 2023, 15(11), 2530; https://doi.org/10.3390/polym15112530 - 31 May 2023
Viewed by 1030
Abstract
Currently, most of the clinically available surgical glues and sealants lack elasticity, good adhesion and biocompatibility properties. Hydrogels as tissue adhesives have received extensive attention for their tissue-mimicking features. Here, a novel surgical glue hydrogel based on a fermentation-derived human albumin (rAlb) and [...] Read more.
Currently, most of the clinically available surgical glues and sealants lack elasticity, good adhesion and biocompatibility properties. Hydrogels as tissue adhesives have received extensive attention for their tissue-mimicking features. Here, a novel surgical glue hydrogel based on a fermentation-derived human albumin (rAlb) and biocompatible crosslinker for tissue-sealant applications has been developed. In order to reduce the risks of viral transmission diseases and an immune response, Animal-Free Recombinant Human Albumin from the saccharomyces yeast strain was used. A more biocompatible crosslinking agent, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC), was used and compared with glutaraldehyde (GA). The design of crosslinked albumin-based adhesive gels was optimized by varying the albumin concentration, the mass ratio between albumin and the crosslinking agent as well as the crosslinker type. Tissue sealants were characterized in terms of mechanical (tensile and shear), adhesive and in vitro biocompatibility properties. The results indicated that the mechanical and adhesive properties improved as the albumin concentration increased and the mass ratio between albumin and crosslinker decreased. Moreover, the EDC-crosslinked albumin gels have better biocompatibility properties than GA-crosslinked glues. Full article
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