Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.6
5.0
Journals
Polymers
Special Issues
Self-Assembled Polymeric Nanostructures for Biomedicine and Industry
share announcement

Self-Assembled Polymeric Nanostructures for Biomedicine and Industry

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 3651

Special Issue Editor

Dr. Joanna Szafraniec-Szczęsny

E-Mail Website
Guest Editor
Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland
Interests: self-assembly; nanoparticles; therapeutic systems; biomedical devices; polymeric systems; drug delivery; diagnosis; sensors

Special Issue Information

Dear Colleagues,

I am pleased to invite you to contribute your research papers, reviews, communications, perspectives, and technical notes for the Special Issue entitled “Self-Assembled Polymeric Nanostructures for Biomedicine and Industry".

The self-assembly phenomenon of amphiphiles relies on the spontaneous arrangement of constituent molecules into well-defined 3D structures due to the specific interactions among the components themselves. The process is important in numerous biological processes, including protein folding, cell membrane formation from assembled lipids, and the formation of DNA double-helical structure. It also exhibits a profound impact on numerous fields due to the opportunity to develop versatile nanostructures of controlled shape, size, and properties. Many structures, including micelles, vesicles, hydrogels, and nanofibers, have been successfully applied to drug and gene delivery research, biosensors manufacturing, crystal engineering, biomedical research, and environmental sciences. However, many issues, including stability of the formed structures, encapsulation efficiency, release characteristics, size control upon changing environmental conditions, and scaling-up, still need to be addressed. This Special Issue is devoted to serve as a platform for exchanging ideas for a better understanding of the complex nature of the self-assembly process, to present recent progress in the biomedical field of polymeric self-assembled nanostructures, and to inspire researchers to develop new advanced polymeric materials.

Dr. Joanna Szafraniec-Szczęsny
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • self-assembly
  • nanoparticles
  • therapeutic systems
  • biomedical devices
  • polymeric systems
  • drug delivery
  • diagnosis
  • sensors

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

17 pages, 3351 KiB  
Article
Quaternized Poly(N,N′-dimethylaminoethyl methacrylate) Star Nanostructures in the Solution and on the Surface
by Paulina Teper, Anna Celny, Agnieszka Kowalczuk and Barbara Mendrek
Polymers 2023, 15(5), 1260; https://doi.org/10.3390/polym15051260 - 01 Mar 2023
Cited by 4 | Viewed by 1560
Abstract
Antibacterial polymeric materials are promising in the fight against resistant bacteria strains. Amongst them, cationic macromolecules with quaternary ammonium groups are one of intensively studied, as they interact with the bacterial membranes causing cell death. In this work, we propose to use nanostructures [...] Read more.
Antibacterial polymeric materials are promising in the fight against resistant bacteria strains. Amongst them, cationic macromolecules with quaternary ammonium groups are one of intensively studied, as they interact with the bacterial membranes causing cell death. In this work, we propose to use nanostructures composed of polycations with star topology for the preparation of antibacterial materials. First, star polymers of N,N′-dimethylaminoethyl methacrylate and hydroxyl-bearing oligo(ethylene glycol) methacrylate P(DMAEMA-co-OEGMA-OH) were quaternized with various bromoalkanes and their solution behavior was studied. It was shown that in water two modes of star nanoparticles were observed, of diameters about 30 nm and up to 125 nm, independently of the quaternizing agent. Separately layers of P(DMAEMA-co-OEGMA-OH) stars were obtained. In this case, the chemical grafting of polymers to the silicon wafers modified with imidazole derivatives was applied, followed by the quaternization of the amino groups of polycations. A comparison of the quaternary reaction in solution and on the surface showed that in the solution it is influenced by the alkyl chain length of the quaternary agent, while on the surface such relationship is not observed. After physico-chemical characterization of the obtained nanolayers, their biocidal activity was tested against two strains of bacteria E. coli and B. subtilis. The best antibacterial properties exhibited layers quaternized with shorter alkyl bromide, where 100% growth inhibition of E. coli and B. subtilis after 24 h of contact was observed. Full article
(This article belongs to the Special Issue Self-Assembled Polymeric Nanostructures for Biomedicine and Industry)
►▼ Show Figures

Figure 1

19 pages, 5033 KiB  
Article
Clindamycin-Loaded Halloysite Nanotubes as the Antibacterial Component of Composite Hydrogel for Bone Repair
by Adrianna Machowska, Joanna Klara, Gabriela Ledwójcik, Kinga Wójcik, Joanna Dulińska-Litewka and Anna Karewicz
Polymers 2022, 14(23), 5151; https://doi.org/10.3390/polym14235151 - 26 Nov 2022
Cited by 9 | Viewed by 1497
Abstract
A new drug delivery system consisting of clindamycin phosphate entrapped in acid-etched halloysite nanotubes was successfully prepared and characterized. It was then used as an antibacterial component of the multicomponent hydrogel designed as a material for bone regeneration. First, halloysite (HNT) was etched [...] Read more.
A new drug delivery system consisting of clindamycin phosphate entrapped in acid-etched halloysite nanotubes was successfully prepared and characterized. It was then used as an antibacterial component of the multicomponent hydrogel designed as a material for bone regeneration. First, halloysite (HNT) was etched and clindamycin phosphate (CP) was entrapped in both raw and modified nanotubes, resulting in HNT-CP and EHNT-CP systems. They were characterized using SEM, TEM, TGA and FTIR; the entrapment efficiency and release of CP from both systems were also studied. EHNT-CP was then used as an antibacterial component of the two hydrogels composed of alginate, collagen and β-TCP. The hydrogels were prepared using different crosslinking procedures but had the same composition. The morphology, porosity, degradation rate, CP release profile, cytocompatibility, antibacterial activity and ability to induce biomineralization were studied for both materials. The hydrogel obtained by a chemical crosslinking with EDC followed by the physical crosslinking with calcium ions had better properties and was shown to have potential as a bone repair material. Full article
(This article belongs to the Special Issue Self-Assembled Polymeric Nanostructures for Biomedicine and Industry)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop