Biopolymer-Based Materials in Medical Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 618

Special Issue Editors


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Guest Editor
Institute of Statistics, National Yang Ming Chiao Tung University, Hsinchu 300093, Taiwan
Interests: anti-NMDA receptor encephalitis; microRNA; molecular biomarkers; phylogenetic analysis; bioinformatics; industry statistics
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Guest Editor
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China
Interests: thin polymer films; hydrogels; nanocomposites; superlyophilic surfaces; microfluidics

Special Issue Information

Dear Colleagues,

Biopolymer-based materials are materials that are primarily composed of biopolymers, which are natural polymers produced by living organisms. These polymers can be derived from renewable resources such as plants, animals, or microorganisms. In recent years, the use of biopolymer-based materials has steadily increased due to their high demand in medical applications. These materials play a significant role in various medical applications due to their biocompatibility, biodegradability, and versatility. The applications of biopolymer-based materials include drug delivery systems, tissue engineering, wound dressings, surgical sealants and adhesives, orthopedic implants, dental applications, diagnostic devices, vaccine delivery, and so on. Since the demand for polymers in medical applications has been significantly increasing, further advanced research on extracting biopolymer-based materials, exploring new materials, and developing the biopolymer-based materials industry is particularly important. 

In addition, although biodegradability is an advantage of biopolymer-based materials, it is also a disadvantage because they may easily suffer from wear and tear due to their intensive interaction with the body. Hence, further studies investigating the effect of their treatment and attempting to understand their related biological mechanisms can contribute to the efficient use of these materials in medical applications. 

Therefore, the current Special Issue on “Biopolymer-based Materials in Medical Applications” invites submissions of reviews and original papers that address any interesting topics concerning the effect of therapy with biopolymer-based materials, their biological mechanisms, and their applications.

Prof. Dr. Hsiuying Wang
Prof. Dr. Pengchao Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biopolymer-based materials
  • biopolymer-based materials therapy
  • biopolymer-based materials industry
  • biomedical applications
  • wound dressings
  • tissue engineering

Published Papers (1 paper)

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Research

10 pages, 2342 KiB  
Article
Preparation of Single-Helical Curdlan Hydrogel and Its Activation with Coagulation Factor G
by Geying Ru, Xiaoshuang Yan, Huijuan Wang and Jiwen Feng
Polymers 2024, 16(10), 1323; https://doi.org/10.3390/polym16101323 - 8 May 2024
Viewed by 404
Abstract
β-1,3-glucans are a kind of natural polysaccharide with immunomodulatory, antitumor, and anti-inflammatory properties. Curdlan, as the simplest linear β-1,3-glucan, possesses a variety of biological activities and thermogelation properties. However, due to the complexity and variability of the conformations of curdlan, the exact structure–activity [...] Read more.
β-1,3-glucans are a kind of natural polysaccharide with immunomodulatory, antitumor, and anti-inflammatory properties. Curdlan, as the simplest linear β-1,3-glucan, possesses a variety of biological activities and thermogelation properties. However, due to the complexity and variability of the conformations of curdlan, the exact structure–activity relationship remains unclear. We prepare a chemically crosslinked curdlan hydrogel with the unique single-helical skeleton (named S gel) in 0.4 wt% NaOH at 40 °C, confirmed by diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS). X-ray diffractometry (XRD) data show that S gel maintains the single-helical crystal structure, and the degree of crystallinity of the S gel is ~24%, which is slightly lower than that of the raw powder (~31%). Scanning electron microscopy (SEM) reveals that S gel has a continuous network structure, with large pores measuring 50–200 μm, which is consistent with its high swelling property. Using the 13C high-resolution magic angle spinning nuclear magnetic resonance (HRMAS NMR) method, we determine that most of the single-helical skeleton carbon signals in the swollen S gel are visible, suggesting that the single-helical skeleton of S gel exhibits fascinating mobility at room temperature. Finally, we reveal that the binding of S gel to coagulation Factor G from tachypleus amebocyte lysate increases and saturates at 20 μL tachypleus amebocyte lysate per mg of S gel. Our prepared S gel can avoid the transformation of curdlan conformations and retain the bioactivity of binding to coagulation Factor G, making it a valuable material for use in the food industry and the pharmaceutical field. This work deepens the understanding of the relationship between the single-helical structure and the activity of curdlan, promoting the development and application of β-1,3-glucans. Full article
(This article belongs to the Special Issue Biopolymer-Based Materials in Medical Applications)
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