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Polymers
Special Issues
Application of Polymers in Targeted Therapy
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Special Issue "Application of Polymers in Targeted Therapy"

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: 5 December 2023 | Viewed by 2360

Special Issue Editors

Dr. Qi Sun

E-Mail Website
Guest Editor
College of Pharmacy, Capital Medical University, Fengtai District, Beijing 100069, China
Interests: nanomaterials; drug delivery systems; cancer therapy
Dr. Zhenzhen Yang

E-Mail Website
Guest Editor
Drug Clinical Trial Center, Institute of Medical Innovation and Research, Peking University Third Hospital, Peking University, Beijing 100191, China
Interests: drug delivery system; nanomedicine; nanobiotechnology
Prof. Dr. Xianrong Qi
E-Mail Website
Guest Editor
Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
Interests: targeting drug delivery; nanotechnology and biotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The development of effective treatments for cancer has been a major goal of the human race. Targeted therapy is the key to improving overall survival while reducing the undesirable adverse effects of cancer treatment. To date, many efforts have been made to develop suitable delivery systems with beneficial characteristics for targeted therapy, including water-soluble high-molecular-weight polymer carriers, polymeric nanoparticles, polymeric micelles, etc. These polymers can be used as complex systems to mediate combination therapies and target specific cells, maximizing therapeutic efficacy and/or reducing side effects. With such a significant and broad impact on human health, the application of polymers in targeted therapy has become an important research topic.

This Special Issue aims to collect research papers, communications and review articles with original contributions to the application of various polymers in targeted therapy.

Dr. Qi Sun
Dr. Zhenzhen Yang
Prof. Dr. Xianrong Qi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Review

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Review
Design and Application of Hybrid Polymer-Protein Systems in Cancer Therapy
by
Qi Sun
,
Zhenzhen Yang
and
Xianrong Qi
Polymers 2023, 15(9), 2219; https://doi.org/10.3390/polym15092219 - 08 May 2023
Viewed by 1855
Abstract
Polymer-protein systems have excellent characteristics, such as non-toxic, non-irritating, good water solubility and biocompatibility, which makes them very appealing as cancer therapeutics agents. Inspiringly, they can achieve sustained release and targeted delivery of drugs, greatly improving the effect of cancer therapy and reducing [...] Read more.
Polymer-protein systems have excellent characteristics, such as non-toxic, non-irritating, good water solubility and biocompatibility, which makes them very appealing as cancer therapeutics agents. Inspiringly, they can achieve sustained release and targeted delivery of drugs, greatly improving the effect of cancer therapy and reducing side effects. However, many challenges, such as reducing the toxicity of materials, protecting the activities of proteins and controlling the release of proteins, still need to be overcome. In this review, the design of hybrid polymer–protein systems, including the selection of polymers and the bonding forms of polymer–protein systems, is presented. Meanwhile, vital considerations, including reaction conditions and the release of proteins in the design process, are addressed. Then, hybrid polymer–protein systems developed in the past decades for cancer therapy, including targeted therapy, gene therapy, phototherapy, immunotherapy and vaccine therapy, are summarized. Furthermore, challenges for the hybrid polymer–protein systems in cancer therapy are exemplified, and the perspectives of the field are covered. Full article
(This article belongs to the Special Issue Application of Polymers in Targeted Therapy)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

1. (submitted) Title: Design and Application of Hybrid Polymer-Protein Systems in Cancer Therapy

Qi Sun 1, Zhenzhen Yang 2 and Xianrong Qi 3

1. College of Pharmacy, Capital Medical University, Fengtai District, Beijing 100069, China

2. Drug Clinical Trial Center, Peking University Third Hospital, Peking University, Beijing 100191, China

3. Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

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